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Repetitious DNA

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Advances in Cell Biology

Abstract

In previous studies in this laboratory (Abelmann, Wagner, and Jeffrey 1970; Abelmann, Jeffrey, and Wagner 1972a, b), the congestive heart failure of Syrian hamsters with hereditary cardiomyopathy (Bajusz et al, 1969; Bajusz, 1969, 1971) was characterized by significant bradycardia, elevation of both right and left ventricular filling pressures, decrease in systemic and increase in pulmonary systolic pressure, increase in stroke volume, and decrease in arteriovenous oxygen difference. The characteristic changes in stroke volume, cardiac output, and arteriovenous oxygen difference in an expanded series of 19 myopathic hamsters in the edematous stage compared to 23 age-matched control animals are illustrated in Figures 1 and 2. Thus, the heart failure of the cardiomyopathic hamster is of the hyperkinetic or high output type.

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References

  • Aloni, Y., L. E. Hatlen, and G. Attardi. 1971. Studies of fractionated HeLa cell metaphase chromosomes. II. Chromosomal distribution of sites for transfer RNA and 5S RNA. J. Molec. Biol., 56:555–563.

    Article  PubMed  CAS  Google Scholar 

  • Arrighi, F. E., M. Mandel, J. Bergendahl, and T. C. Hsu. 1970. Buoyant densities of DNA of mammals. Biochem. Genet. 4:367–376.

    Article  PubMed  CAS  Google Scholar 

  • Astell, C. R., D. T. Suzuki, R. P. Klett, M. Smith, and I. H. Goldberg. 1969. The intracellular location of the adenine- and thymine-rich component of deoxyribonucleate in testicular cells of the crab, Cancer productus. Exp. Cell Res., 54:3–9.

    Article  PubMed  CAS  Google Scholar 

  • Atkin, N. B., G. Mattinson, W. Becak, and S. Ohno. 1965. The comparative DNA content of 19 species of placental mammals, reptiles, and birds. Chromosoma, 17:1–10.

    Article  PubMed  CAS  Google Scholar 

  • Attardi, G., P. -C. Huang, and S. Kabat. 1965. Recognition of ribosomal RNA sites in DNA. I. Analysis of thetf. coli system. Proc. Nat. Acad. Sci. U.S.A., 53:1490–1498.

    Article  CAS  Google Scholar 

  • Baglioni, C. 1963. Correlations between,genetics and chemistry of human hemoglobins. In Molecular Genetics, Taylor, J. H., ed., New York and London, Academic Press, Inc., Part I, pp. 405–475.

    Google Scholar 

  • Baguley, B. C, and R. K. Ralph. 1966. Origin of transfer RNA. Biochem. Biophys. Res. Commun. 22:308–315.

    Article  PubMed  CAS  Google Scholar 

  • Bailey, G. S., and A. C. Wilson. 1968. Homologies between isoenzymes of fishes and those of higher vertebrates. Evidence for multiple H4 lactate dehydrogenases in trout. J. Biol. Chem., 243:5843–5853.

    PubMed  CAS  Google Scholar 

  • Barton, D. W. 1951. Localized chiasmata in the differentiated chromosomes of the tomato. Genetics, 36:374–381.

    PubMed  CAS  Google Scholar 

  • Beermann, W. 1967. Gene action at the level of the chromosome. In Heritage from Mendel, Brink, R. A. ed., Madison, Milwaukee, and London, The University of Wisconsin Press, pp. 179–201.

    Google Scholar 

  • Bekhor, I., J. Bonner, and G. K. Dahmus. 1969a. Hybridization of chromosomal RNA to native DNA. Proc. Nat. Acad. Sci. U.S.A., 62:271–277.

    Article  CAS  Google Scholar 

  • Bekhor, I., G. M. Kung, and J. Bonner. 1969b. Sequence-specific interaction of DNA and chromosomal protein. J. Molec. Biol., 39:351–364.

    Article  PubMed  CAS  Google Scholar 

  • Benzer, S. 1957. The elementary units of heredity. In The Chemical Basis of Heredity, McElroy, W. D., and B. Glass, eds., Baltimore, The Johns Hopkins Press, pp. 70–93.

    Google Scholar 

  • Berendes, H. D., and H. G. Keyl. 1967. Distribution of DNA in heterochromatin and euchromatin of polytene nuclei of Drosophila hydei. Genetics, 57:1–13.

    PubMed  CAS  Google Scholar 

  • Birnstiel, M. L., H. Wallace, J. L. Sirlin, and M. Fischberg. 1966. Localization of the ribosomal DNA complements in the nucleolar organizer region of Xenopus laevis. In International Symposium on the Nucleolus-Its Structure and Function, Vincent, W. S., and O. L. Miller, eds., Nat. Cancer Inst. Monogr. 23:431–444.

    Google Scholar 

  • Birnstiel, M. L., J. Speirs, I. Purdom, K. Jones, and U. E. Loening. 1968. Properties and composition of the isolated ribosomal DNA satellite of Xenopus laevis. Nature (London), 219:454–463.

    Article  CAS  Google Scholar 

  • Bolton, E. T., R. J. Britten, D. B. Cowie, R. B. Roberts, P. Szafranski, and M. J. Waring. 1965. Biophysics. Carnegie Inst. Year Book, 64:313–333.

    Google Scholar 

  • Bostock, C. J., and D. M. Prescott. 1971a. The buoyant density of DNA synthesized at different stages of the S phase of mouse L-cells. Exp. Cell Res., 64:267–274.

    Article  PubMed  CAS  Google Scholar 

  • Bostock, C. J., and D. M. Prescott. 1971b. The buoyant density of DNA synthesized at different parts of the S phase in Chinese hamster cells. Exp. Cell Res., 64:481–484.

    Article  PubMed  CAS  Google Scholar 

  • Bostock, C. J., and D. M. Prescott. Unpublished data.

    Google Scholar 

  • Brenner, D. J., M. J. Fournier, and B. P. Doctor. 1970. Isolation and partial characterization of the transfer ribonucleic acid cistrons from Escherichia coli. Nature (London), 227:448–451.

    Article  CAS  Google Scholar 

  • Breuer, M. E., and C. Pavan. 1955. Behavior of polytene chromosomes of Rhynchosciara angelae at different stages of larval development. Chromosoma, 7:371–386.

    Article  Google Scholar 

  • Bridges, C. B. 1938. A revised map of the salivary gland X-chromosome of Drosophila melanogaster. J. Hered., 29:11–14.

    Google Scholar 

  • Britten, R. J. 1968. Repeated sequences of human DNA. Carnegie Inst. Year Book, 67:327–330.

    Google Scholar 

  • Britten, R. J. 1969. Observed properties of repeated DNA sequences. Carnegie Inst. Year Book, 68:376–378.

    Google Scholar 

  • Britten, R. J. and E. H. Davidson. 1969. Gene regulation for higher cells: A theory. Science 165:349–357.

    Article  PubMed  CAS  Google Scholar 

  • Britten, R. J., and D. E. Kohne. 1966. Nucleotide sequence repetition in DNA. Carnegie Inst. Year Book, 65:78–106.

    Google Scholar 

  • Britten, R. J., and D. E. Kohne. 1967. Repeated nucleotide sequences. Carnegie Inst. Year Book, 66:73–88.

    Google Scholar 

  • Britten, R. J., and D. E. Kohne. 1968. Repeated sequences in DNA. Science, 161:529–540.

    Article  PubMed  CAS  Google Scholar 

  • Britten, R. J., and A. V. Rake. 1968. Search for saltatory replication. Carnegie Inst. Year Book, 67:325–327.

    Google Scholar 

  • Britten, R. J., and J. Smith. 1969. A bovine genome. Carnegie Inst. Year Book, 68:378–386.

    Google Scholar 

  • Brown, D. D., and I. B. Dawid. 1968. Specific gene amplification in oocytes. Science, 160:272–280.

    Article  PubMed  CAS  Google Scholar 

  • Britten, R. J., and J. B. Gurdon. 1964. Absence of ribosomal RNA synthesis in the anucleolate mutant of Xenopus laevis. Proc. Nat. Acad. Sci. U.S.A., 51:139–146.

    Article  Google Scholar 

  • Britten, R. J., and C. S. Weber. 1968a. Gene linkage by RNA-DNA hybridization. I. Unique DNA sequences homologous to 4S RNA, 5S RNA and ribosomal RNA. J. Molec. Biol., 34:661–680.

    Article  Google Scholar 

  • Britten, R. J., and C. S. Weber. 1968b. Gene linkage by RNA-DNA hybridization. II. Arrangement of the redundant gene sequences for 28S and 18S ribosomal RNA. J. Molec. Biol., 34:681–697.

    Article  Google Scholar 

  • Brown, S. W. 1966. Heterochromatin. Science, 151:417–425.

    Article  PubMed  CAS  Google Scholar 

  • Brownlee, G. G., F. Sanger, and B. G. Barrell. 1968. The sequence of 5S ribosomal ribonucleic acid. J. Molec. Biol., 34:379–412.

    Article  PubMed  CAS  Google Scholar 

  • Burgi, E., and A. D. Hershey. 1961. A relative molecular weight series derived from the nucleic acid of bacteriophage T2. J. Molec. Biol., 3:458–472.

    Article  PubMed  CAS  Google Scholar 

  • Callan, H. G. 1967. The organization of genetic units in chromosomes. J. Cell Sci., 2:1–7.

    PubMed  CAS  Google Scholar 

  • Callan, H. G. and L. Lloyd. 1960. Lampbrush chromosomes of crested newts Triturus cristatus (Laurenti). Phil. Trans. Roy. Soc. London [Biol.], 243:135–219.

    Article  Google Scholar 

  • Callan, H. G. and H. C. MacGregor. 1958. Action of DNase on lampbrush chromosomes. Nature (London), 181:1479–1480.

    Article  CAS  Google Scholar 

  • Cameron, F. M., and H. Rees. 1967. The influence of B chromosomes on meiosis in Lolium. Heredity (London) 22:446–450.

    Article  Google Scholar 

  • Campbell, A. 1965. The steric effect in lysogenization by bacteriophage lambda. I. Lysogenization of a partially diploid strain of Escherichia coli K12. Virology, 27:329–339.

    Article  PubMed  CAS  Google Scholar 

  • Chiscon, J. A., and D. E. Kohne. 1969. DNA sequences present as multiple copies in E. coli. Carnegie Inst. Year Book, 68:388–391.

    Google Scholar 

  • Chovnick, A. 1966. Genetic organization in higher organisms. Proc. Roy. Soc. London [Biol.], 164:198–208.

    Article  CAS  Google Scholar 

  • Chun, E. H. L., and J. W. Littlefield. 1963. The replication of the minor DNA component of mouse fibroblasts. J. Molec. Biol. 7:245–248.

    Article  PubMed  CAS  Google Scholar 

  • Church, K. 1965. Replication of chromatin in mouse mammary epithelial cells grown in vitro. Genetics, 52:843–849.

    PubMed  CAS  Google Scholar 

  • Church, R. B., and B. J. McCarthy. 1967a. Ribonucleic acid synthesis in regenerating and embryonic liver. I. The synthesis of new species of RNA during regeneration of mouse liver after partial hepatectomy. J. Molec. Biol., 23:459–475.

    Article  PubMed  CAS  Google Scholar 

  • Church, R. B., and B. J. McCarthy. 1967b. Ribonucleic acid synthesis in regenerating and embryonic liver. II. The synthesis of RNA during embryonic liver development and its relationship to regenerating liver. J. Molec. Biol., 23:477–486.

    Article  PubMed  CAS  Google Scholar 

  • Comings, D. E. 1967. Histones of genetically active and inactive chromatin. J. Cell Biol. 35:699–708.

    Article  PubMed  CAS  Google Scholar 

  • Comings, D. E. 1968. The rationale for an ordered arrangement of chromatin in the interphase nucleus. Amer. J. Hum. Genet., 20:440–460.

    PubMed  CAS  Google Scholar 

  • Comings, D. E. and R. O. Berger. 1969. Gene products of Amphiuma: An amphibian with an excessive amount of DNA. Biochem. Genet., 2:319–333.

    Article  PubMed  CAS  Google Scholar 

  • Comings, D. E. and E. Mattoccia. 1970a. Studies of microchromosomes and a G-C rich DNA satellite in the quail. Chromosoma, 30:202–214.

    PubMed  CAS  Google Scholar 

  • Comings, D. E., and E. Mattoccia. 1970b. Replication of repetitious DNA and the S period. Proc. Nat. Acad. Sci. U.S.A., 67:448–455.

    Article  CAS  Google Scholar 

  • Cooper, S., and C. E. Helmstetter. 1968. Chromosome replication and the division cycle of Escherichia coli B/r. J. Molec. Biol., 31:519–540.

    Article  PubMed  CAS  Google Scholar 

  • Corneo, G., E. Ginelli, and E. Polli. 1970a. Repeated sequences in human DNA. J. Molec. Biol., 48:319–327.

    Article  PubMed  CAS  Google Scholar 

  • Corneo, G., E. Ginelli, and E. Polli. 1970b. Different satellite deoxyribonucleic acids of guinea pig and ox. Biochemistry, 9:1565–1571.

    Article  PubMed  CAS  Google Scholar 

  • Crick, F. H. C. 1966. Codon-anticodon pairing: the wobble hypothesis. J. Molec. Biol., 19:548–555.

    Article  PubMed  CAS  Google Scholar 

  • Cutler, R. G., and J. E. Evans. 1967. Relative transcription activity of different segments of the genome throughout the cell division cycle of Escherichia coli. The mapping of ribosomal and transfer RNA and the determination of the direction of replication. J. Molec. Biol., 26:91–105.

    Article  PubMed  CAS  Google Scholar 

  • Da Cunha, A. B., C. Pavan, J. S. Morgante, and M. C. Garrido. 1969. Studies on cytology and differentiation in Sciaridae. II. DNA redundancy in salivary gland cells of Hybosciara fragilis (Diptera, Sciaridae). Genetics, 61 (Suppl.):335–349.

    PubMed  Google Scholar 

  • Darnell, J. E., Jr. 1968. Ribonucleic acids from animal cells. Bact. Rev., 32:262–290.

    PubMed  CAS  Google Scholar 

  • Davidson, E. H., and B. R. Hough. 1969. High sequence diversity in the RNA synthesized at the lampbrush stage of oogenesis. Proc. Nat. Acad. Sci. U.S.A., 63:342–349.

    Article  CAS  Google Scholar 

  • Davidson, E. H., M. Crippa, and A. E. Mirsky. 1968. Evidence for the appearance of novel gene products during amphibian blastulation. Proc. Nat. Acad. Sci. U.S.A., 60:152–159.

    Article  CAS  Google Scholar 

  • Dawid, I. B., D. D. Brown, and R. H. Reeder. 1970. Composition and structure of chromosomal and amplified ribosomal DNA’s of Xenopus laevis. J. Molec. Biol., 51:341–360.

    Article  PubMed  CAS  Google Scholar 

  • Demerec, M. 1956. A quantitative study of certain gene loci in Salmonella. Cold Spring Harbor Symp. Quant. Biol., 21:113–121.

    Article  PubMed  CAS  Google Scholar 

  • Denis, H. 1966. Gene expression in amphibian development. II. Release of the genetic information in growing embryos. J. Molec. Biol., 22:285–304.

    Article  PubMed  CAS  Google Scholar 

  • Doty, P., J. Marmur, J. Eigner, and C. Schildkraut. 1960. Strand separation and specific recombination in deoxyribonucleic acids: Physical chemical studies. Proc. Nat. Acad. Sci. U.S.A., 46:461–476.

    Article  CAS  Google Scholar 

  • Eberle, H., and K. G. Lark. 1967. Chromosome replication in Bacillus subtilis cultures growing at different rates. Proc. Nat. Acad. Sci. U.S.A., 57:95–101.

    Article  CAS  Google Scholar 

  • Edstrom, J. E. 1968. Masters, slaves and evolution. Nature (London), 220:1196–1198.

    Article  CAS  Google Scholar 

  • Feldman, M. 1966. The effect of chromosomes 5B, 5D, and 5A on chromosomal pairing in Triticum aestivum. Proc. Nat. Acad. Sci. U.S.A., 55:1447–1453.

    Article  CAS  Google Scholar 

  • Feldman, M., T. Mello-Sampayo, and E. R. Sears. 1966. Somatic association in Triticum aestivum. Proc. Nat. Acad. Sci. U.S.A., 56:1192–1199.

    Article  CAS  Google Scholar 

  • Ficq, A., and C. Pavan. 1957. Autoradiography of polytene chromosomes of Rhynchosciara angelae at different stages of larval development. Nature (London), 180:983–984.

    Article  CAS  Google Scholar 

  • Flamm, W. G., N. J. Bernheim, and P. E. Brubaker. 1971. Density gradient analysis of newly replicated DNA from synchronized mouse lymphoma cells. Exp. Cell Res., 64:97–104.

    Article  PubMed  CAS  Google Scholar 

  • Flamm, W. G., H. E. Bond, and H. E. Burr. 1966. Density-gradient centrifugation of DNA in a fixed-angle rotor. Biochim. Biophys. Acta, 129:310–319.

    Article  CAS  Google Scholar 

  • Flamm, W. G., M. McCallum, and P. M. B. Walker. 1967. The isolation of complementary strands from a mouse DNA fraction. Proc. Nat. Acad. Sci. U.S.A., 57:1729–1734.

    Article  CAS  Google Scholar 

  • Flamm, W. G., P. M. B. Walker, and M. McCallum. 1969. Some properties of the single strands isolated from the DNA of the nuclear satellite of the mouse (Mus musculus). J. Molec. Biol., 40:423–443.

    Article  PubMed  CAS  Google Scholar 

  • Forget, B. G., and S. M. Weisman. 1969. The nucleotide sequence of ribosomal 5S RNA from KB cells. J. Biol. Chem., 244:3148–3165.

    PubMed  CAS  Google Scholar 

  • Fox, D. P. 1970. A non-doubling series of somatic tissues of the locusts Schistocerca gregaria (Forskal) and Locusta migratoria (Linn.). Chromosoma, 29:446–461.

    Article  PubMed  CAS  Google Scholar 

  • Frenster, J. H. 1967. Mechanisms of repression and de-repression within interphase chromatin. In In Vitro, Dawe, C. J. ed., Baltimore, The Williams & Wilkins Co., Vol. I, pp. 78–101.

    Google Scholar 

  • Gall, J. G., and M. L. Pardue. 1969. Formation and detection of RNA-DNA hybrid molecules in cytological preparations. Proc. Nat. Acad. Sci. U.S.A., 63:378–383.

    Article  CAS  Google Scholar 

  • Gall, J. G., H. C. MacGregor, and M. E. Kidston. 1969. Gene amplification in the oocytes of dytiscid water beetles. Chromosoma, 26:169–187.

    Article  PubMed  CAS  Google Scholar 

  • Galton, M., and S. P. Holt. 1965. Asynchronous replication of the mouse sex chromosomes. Exp. Cell Res., 37:111–116.

    Article  PubMed  CAS  Google Scholar 

  • Gelderman, A. H., A. V. Rake, and R. J. Britten. 1968. Genetic expression of nonrepeated DNA sequences in the mouse. Carnegie Inst. Year Book, 67:320–325.

    Google Scholar 

  • Georgiev, G. P. 1969. On the structural organization of operon and the regulation of RNA synthesis in animal cells. J. Theor. Biol., 25:473–490.

    Article  PubMed  CAS  Google Scholar 

  • Giacomoni, D., and S. Spiegelman. 1962. Origin and biologic individuality of the genetic dictionary. Science, 138:1328–1331.

    Article  PubMed  CAS  Google Scholar 

  • Gibson, D. A. 1970. Somatic homologue association. Nature (London), 227:164.

    Article  CAS  Google Scholar 

  • Gibson, D. A. Personal Communication.

    Google Scholar 

  • Gibson, I., and G. Hewitt. 1970. Isolation of DNA from B chromosomes in grasshoppers. Nature (London), 225:67–68.

    Article  CAS  Google Scholar 

  • Gilbert, W., and B. Muller-Hill. 1966. Isolation of the lac repressor. Proc. Nat. Acad. Sci. U.S.A., 56:1891–1898.

    Article  CAS  Google Scholar 

  • Gilbert, W., and B. Muller-Hill. 1967. The lac operator is DNA. Proc. Nat. Acad. Sci. U.S.A., 58:2415–2421.

    Article  CAS  Google Scholar 

  • Gillespie, D., and S. Spiegelman. 1965. A quantitative assay for DNA-RNA hybrids with DNA immobolized on a membrane. J. Molec. Biol., 12:829–842.

    Article  PubMed  CAS  Google Scholar 

  • Gillis, M., J. De Ley, and M. De Cleene. 1970. The determination of molecular weight of bacterial genome DNA from renaturation rates. Europ. J. Biochem., 12:143–153.

    Article  PubMed  CAS  Google Scholar 

  • Glisin, V. R., M. V. Glism, and P. Doty. 1966. The nature of messenger RNA in the early stages of sea urchin development. Proc. Nat. Acad. Sci. U.S.A., 56:285–289.

    Article  CAS  Google Scholar 

  • Goodman, H. M., and A. Rich. 1962. Formation of a DNA-soluble RNA hybrid and its relation to the origin, evolution, and degeneracy of soluble RNA. Proc. Nat. Acad. Sci. U.S.A., 48:2101–2109.

    Article  CAS  Google Scholar 

  • Green, M. 1969. Chemical composition of animal viruses. In The Biochemistry of Virsuses, Levy, H. B., ed., New York and London, Marcel Dekker, pp. 1–54.

    Google Scholar 

  • Green, M., M.Pina, R. Kimes, P. C. Wensink, L. A. MacHattie, and C. A. Thomas, Jr. 1967. Adenovirus DNA. I. Molecular weight and conformation. Proc. Nat. Acad. Sci. U.S.A., 57:1302–1309.

    Article  CAS  Google Scholar 

  • Greenwood, P. H., D. E. Rosen, S. H. Weitzman, and G. S. Myers. 1966. Phyletic studies of teleostean fishes, with a provisional classification of living forms. Bull. Amer. Mus. Natur. Hist. 131 (Article 4):341–455.

    Google Scholar 

  • Hannah, A. 1951. Localization and function of heterochromatin in Drosophila melanogaster. In Advances in Genetics, Demerec, M., ed., New York, Academic Press, Inc., Vol. IV, pp. 87–125.

    Google Scholar 

  • Hansen-Melander, E. 1965. The relation of sex chromosomes to chromocenters in somatic cells of Microtus agrestis (L.). Hereditas (Lund), 52:357–366.

    Article  CAS  Google Scholar 

  • Harel, J., N. Hanania, H. Tapiero, and L. Harel. 1968. RNA replication by nuclear satellite DNA in different mouse cells. Biochem. Biophys. Res. Commun., 33:696–701.

    Article  PubMed  CAS  Google Scholar 

  • Hatch, F. T. Personal Communication.

    Google Scholar 

  • Hatch, F. T., and J. A. Mazrimas. 1970. Satellite DNAs in the kangaroo rat. Biochim. Biophys. Acta., 224:291–294.

    Article  PubMed  CAS  Google Scholar 

  • Hatlen, L., and G. Attardi. 1971. Proportion of the HeLa cell genome complementary to transfer RNA and 5S RNA. J. Molec. Biol, 56:535–553.

    Article  PubMed  CAS  Google Scholar 

  • Hays, J. B., and B. H. Zimm. 1970. Flexibility and stiffness in nicked DNA. J. Molec. Biol., 48:297–317.

    Article  PubMed  CAS  Google Scholar 

  • Hennig, W. 1968. Ribonucleic acid synthesis of the Y-chromosome of Drosophila hydei. J. Molec. Biol., 38:227–239.

    Article  PubMed  CAS  Google Scholar 

  • Hennig, W., and P. M. B. Walker. 1970. Variations in the DNA from two rodent families (Cricetidae and Muridae). Nature (London), 225:915–919.

    Article  CAS  Google Scholar 

  • Ptashne, M. 1967a. Specific binding of the X phage repressor to X DNA. Nature (London), 214:232–234.

    Article  CAS  Google Scholar 

  • Ptashne, M. 1967b. Isolation of the X phage repressor. Proc. Nat. Acad. Sci. U.S.A., 57:306–313.

    Article  CAS  Google Scholar 

  • Quincey, R. V., and S. H. Wilson. 1969. The utilization of genes for ribosomal RNA, 5S RNA, and transfer RNA in liver cells of adult rats. Proc. Nat. Acad. Sci. U.S.A., 64:981–988.

    Article  CAS  Google Scholar 

  • Quiroz-Gutierrez, A., and S. Ohno. 1970. The evidence of gene duplication for S-form NADP-linked isocitrate dehydrogenase in carp and goldfish. Biochem. Genet., 4:93–99.

    Article  PubMed  CAS  Google Scholar 

  • Ratnayake, W. E. 1968. Hypothesis to explain synapsis of meiotic chromosomes. Nature (London), 217:1070.

    Article  CAS  Google Scholar 

  • Reed, N. 1969. Fractionation of rat repeated sequences according to thermal stability. Carnegie Inst. Year Book, 68:386–388.

    Google Scholar 

  • Rhoades, M., L. A. MacHattie, and C. A. Thomas, Jr. 1968. The P22 bacteriophage DNA molecule. I. The mature form. J. Molec. Biol., 37:21–40.

    Article  CAS  Google Scholar 

  • Richardson, C. C., R. B. Inman, and A. Kornberg. 1964. Enzymic synthesis of deoxyribonucleic acid. XVIII. The repair of partially single-stranded DNA templates by DNA polymerase. J. Molec. Biol., 9:46–69.

    Article  PubMed  CAS  Google Scholar 

  • Ris, H. 1957. Chromosome structure.In The Chemical Basis of Heredity. McElroy, W. D., and G. Bentley, eds., Baltimore, The Johns Hopkins Press, pp. 23–62.

    Google Scholar 

  • Ritossa, F. M., K. C. Atwood, D. L. Lindsley, and S. Spiegelman. 1966. On the chromosomal distribution of DNA complementary to ribosomal and soluble RNA. In International Symposium on the Nucleolus-Its Structure and Function, Vincent, W. S., and O. L. Miller, eds. Nat. Cancer Inst. Mongr., 23:449–472.

    Google Scholar 

  • Roberts, P. A. 1966. A tandem duplication that lowers recombination throughout a chromosome arm of Drosophila melanogaster. Genetics, 54:969–979.

    PubMed  CAS  Google Scholar 

  • Robertson, W. R. B. 1916. Chromosome studies. I. Taxonomic relationships shown in the chromosomes of Tettigidae and Acridihae: V-shaped chromosomes and their significance in Acrididae, Locustidae, and Gryllidae: Chromosomes and variation. J. Morph., 27:179–220.

    Article  Google Scholar 

  • Ros, Y. 1968. Repartition des chromosomes humains au stade metaphase de la division cellulaire. Humangentik, 6:110–117.

    Article  CAS  Google Scholar 

  • Roth, T. F., and M. Ito. 1967. DNA-dependent formation of the synaptinemal complex at meiotic prophase. J. Cell Biol., 35:247–255.

    Article  PubMed  CAS  Google Scholar 

  • Rothfels, K., E. Sexsmith, M. Heimburger, and M. O. Krause. 1966. Chromosome size and DNA content of species of Anemone L and related genera (Ranunculaceae). Chromosoma, 20:54–74.

    Article  Google Scholar 

  • Rubenstein, I., C. A. Thomas, Jr., and A. D. Hershey. 1961. The molecular weights of T2 bacteriophage DNA and its first and second breakage products. Proc. Nat. Acad. Sci. U.S.A., 47:1113–1122.

    Article  CAS  Google Scholar 

  • Rudkin, G. T. 1961. Cytochemistry in the ultraviolet, in Submicrogram Experimentation, Cheronis, N. D., ed., New York & London, Interscience Publishers, pp. 261–273.

    Google Scholar 

  • Rudkin, G. T. 1963. The structure and function of heterochromatin. In Proceedings of the 11th International Congress on Genetics, Geerts, S. J., ed., New York Pergamon Press, Vol. 2, pp. 359–374.

    Google Scholar 

  • Rudkin, G. T., and S. L. Corlette. 1957. Disproportionate synthesis of DNA in a polytene chromosome region. Proc. Nat. Acad. Sci. U.S.A., 43:964–968.

    Article  CAS  Google Scholar 

  • Russell, R. L., J. N. Abelson, A. Landy, M. L. Gefter, S. Brenner, and J. D. Smith. 1970. Duplicate genes for tyrosine transfer RNA in Escherichia coli. J. Molec. Biol., 47:1–13.

    Article  PubMed  CAS  Google Scholar 

  • Salomon, R., A. M. Kaye, and M. Herzberg. 1969. Mouse nuclear satellite DNA: 5-methylcytosine content, pyrimidine isoplith distribution and electron microscopic appearance. J. Molec. Biol., 43:581–592.

    Article  PubMed  CAS  Google Scholar 

  • Sambrook, J., H. Westphal, P. R. Srinivasan, and R. Dulbecco. 1968. The integrated state of viral DNA in SV40-transformed cells. Proc. Nat. Acad. Sci. U.S.A., 60:1288–1295.

    Article  CAS  Google Scholar 

  • Scherrer, K., L. Marcaud, F. Zajdela, I. M. London, and F. Gros. 1966. Patterns of RNA metabolism in a differentiated cell: A rapidly labeled, unstable 60S RNA with messenger properties in duck erythroblasts. Proc. Nat. Acad. Sci. U.S.A., 56:1571–1578.

    Article  CAS  Google Scholar 

  • Schildkraut, C. L., and J. J. Maio. 1968. Studies on the intranuclear distribution and properties of mouse satellite DNA. Biochim. Biophys. Acta, 161:76–93.

    Article  PubMed  CAS  Google Scholar 

  • Schildkraut, C. L., J. Marmur, and P. Doty. 1961. The formation of hybrid DNA molecules and their use in studies of DNA homologies. J. Molec. Biol., 3:595–617.

    Article  PubMed  CAS  Google Scholar 

  • Schmid, W. 1967. Heterochromatin in mammals. Arch. Klaus. Stift. Vererbungsforsch., 42:1–60.

    CAS  Google Scholar 

  • Schweizer, E., C. MacKechnie, and H. O. Halvorson. 1969. The redundancy of ribosomal and transfer RNA genes in Saccharomyces cerevisiae. J. Molec. Biol., 40:261–277.

    Article  PubMed  CAS  Google Scholar 

  • SSchaud, J., G. Streisinger, J. Emrich, J. Newton, H. Lanford, H. Reinhold, and M. M. Stahl. 1965. Chromosome structure in phage T4. II. Terminal redundancy and heterozygosis. Proc. Nat. Acad. Sci. U.S.A., 54:1333–1339.

    Article  Google Scholar 

  • Shalitin, C, and F. W. Stahl. 1965. Additional evidence for two kinds of heterozygotes in phage T4. Proc. Nat. Acad. Sci. U.S.A., 54:1340–1341.

    Article  CAS  Google Scholar 

  • Shearer, R. W., and B. J. McCarthy. 1967. Evidence for ribonucleic acid molecules restricted to the cell nucleus. Biochemistry 6:283–289.

    Article  PubMed  CAS  Google Scholar 

  • Sidebottom, E., and H. Harris. 1969. The role of the nucleolus in the transfer of RNA from nucleus to cytoplasm. J. Cell Sci., 5:351–364.

    CAS  Google Scholar 

  • Singer, S. J., and R. F. Doolittle. 1966. Antibody active sites and immunoglobulin molecules. Science, 153:13–25.

    Article  PubMed  CAS  Google Scholar 

  • Skinner, D. M., W. G. Beattie, M. S. Kerr, and D. E. Graham. 1970. Satellite DNAs in Crustacea: Two different components with the same density in neutral CsC1gradients. Nature (London), 227:837–839.

    Article  CAS  Google Scholar 

  • Smith, B. J. 1970. Light satellite-band DNA in mouse cells infected with polyoma virus. J. Molec. Biol., 47:101–106.

    Article  PubMed  CAS  Google Scholar 

  • Smith, I., D. Dubnau, P. Morell, and J. Marmur. 1968. Chromosomal location of DNA base sequences complementary to transfer RNA and to 5S, 16S and 23S ribosomal RNA in Bacillus subtilis. J. Molec. Biol., 33:123–140.

    Article  PubMed  CAS  Google Scholar 

  • Smith, M. 1964. Deoxyribonucleic acids of Crustacea. J. Molec. Biol., 9:17–23.

    Article  PubMed  CAS  Google Scholar 

  • Soeiro, R., and J. E. Darnell. 1970. A comparison between heterogeneous nuclear RNA and polysomal messenger RNA in HeLa cells by RNA-DNA hybridization. J. Cell Biol., 44:467–475.

    Article  PubMed  CAS  Google Scholar 

  • Sorm, F., and B. Keil. 1962. Regularities in the primary structure of proteins. Advances Protein Chem., 17:167–207.

    Article  CAS  Google Scholar 

  • Southern, D. I. 1970. Polymorphism involving heterochromatic segments in Metrioptera brachyptera. Chromosoma, 30:154–168.

    Article  PubMed  CAS  Google Scholar 

  • Southern, E. M. 1970. Base sequence and evolution of guinea-pig a-satellite DNA. Nature (London), 227:794–798.

    Article  CAS  Google Scholar 

  • Stack, S. M., and W. V. Brown. 1969. Somatic pairing, reduction and recombination: An evolutionary hypothesis of meiosis. Nature (London), 222:1275–1276.

    Article  CAS  Google Scholar 

  • Stahl, F. W., H. Modersohn, B. E. Terzaghi, and J. M. Crasemann. 1965. The genetic structure of complementation heterozygotes. Proc. Nat. Acad. Sci. U.S.A., 54:1342–1345.

    Article  CAS  Google Scholar 

  • Stebbins, G. L. 1966. Chromosomal variation and evolution. Science, 152:1463–1469.

    Article  PubMed  CAS  Google Scholar 

  • Stern, C. 1936. Somatic crossing over and segregation in Drosophila melanogaster. Genetics, 21:625–730.

    PubMed  CAS  Google Scholar 

  • Strack, H. B., and A. D. Kaiser. 1965. On the structure of the ends of lambda DNA. J. Molec. Biol., 12:36–49.

    Article  PubMed  CAS  Google Scholar 

  • Streisinger, G., R. S. Edgar, and G. H. Denhardt. 1964. Chromosome structure in phage T4.1. Circularity of the linkage map. Proc. Nat. Acad. Sci. U.S.A., 51:775–779.

    Article  CAS  Google Scholar 

  • Studier, F. W. 1969. Effects of the conformation of single-stranded DNA on renaturation and aggregation. J. Molec. Biol., 41:199–209.

    Article  PubMed  CAS  Google Scholar 

  • Sueoka, N. 1961. Variation and heterogeneity of base composition of deoxyribonucleic acids: A compilation of old and new data. J. Molec. Biol., 3:31–40.

    Article  CAS  Google Scholar 

  • Sussman, M. 1970. Model for quantitative and qualitative control of mRNA translation in eukaryotes. Nature (London) 225:1245–1246.

    Article  CAS  Google Scholar 

  • Swanson, C. P. 1957. Cytology and Cytogenetics. Englewood Cliffs, Prentice-Hall, Inc.

    Google Scholar 

  • Swartz, M. N., T. A. Trautner, and A. Kornberg. 1962. Enzymatic synthesis of deoxyribonucleic acid. J. Biol. Chem., 237:1961–1967.

    PubMed  CAS  Google Scholar 

  • Swift, H. 1962. Nucleic acids and cell morphology in dipteran salivary glands. In The Molecular Control of Cellular Activity, Allen, J. M., ed., New York, McGraw-Hill Book Company, pp. 73–126.

    Google Scholar 

  • Tartof, K. D., and R. P. Perry. 1970. The 5S RNA genes of Drosophila melanogaster. J. Molec. Biol., 51:171–183.

    Article  PubMed  CAS  Google Scholar 

  • Taylor, J. H. 1963. DNA synthesis in relation to chromosome reproduction and the reunion of breaks. J. Cell Comp. Physiol., 62 (Suppl. l):73–86.

    Article  CAS  Google Scholar 

  • Taylor, J. H. 1969. The regulation of DNA replication in chromosomes of higher cells. In Nucleic Acid Metabolism Cell Differentiation and Cancer Growth, Cowdrey. E. V. and Seno, S., eds.,New York, Pergamon Press, pp. 231–239.

    Google Scholar 

  • Thomas, C. A. Jr. 1967. The rule of the ring. J. Cell Physiol., 70 (Suppl. 1): 13–34.

    Article  PubMed  CAS  Google Scholar 

  • Thomas, C. A. Jr., 1971. The theory of the master gene. In The Neurosciences: Second Study Program, Schmitt, F. O., ed., New York, Rockefeller University Press. (In Press.)

    Google Scholar 

  • Thomas, C. A. Jr., and L. A. MacHattie. 1964. Circular T2 DNA molecules. Proc. Nat. Acad. Sci. U.S.A., 52:1297–1301.

    Article  CAS  Google Scholar 

  • Thomas, C. A. Jr., B. A. Hamkalo, D. N. Misra, and C. S. Lee. 1970. Cyclization of eucaryotic deoxyribonucleic acid fragments. J. Molec. Biol., 51:621–632.

    Article  PubMed  Google Scholar 

  • Tobia, A., C. L. Schildkraut, and J. J. Maio. 1970. DNA replication in synchronized cultured mammalian cells. I. Time of synthesis of molecules of different average guanine + cytosine content. J. Molec. Biol., 54:499–515.

    Article  PubMed  CAS  Google Scholar 

  • Ullerich, F-H. 1966. Karyotyp und DNS-Gehalt von Bufo bufo, B. Viridis,B. Bufo x B. viridis und B. Calamita (Amphibia, Anura). Chromosoma, 18:316–342.

    Article  Google Scholar 

  • Ullerich, F-H. 1967. Weitere untersuchungen über Chromosomenverhaltnisse und DNS-Gehalt bei Anuren (Amphibia). Chromosoma, 21:345–368.

    Article  PubMed  CAS  Google Scholar 

  • Wagenaar, E. B. 1969. End-to-end chromosome attachments in mitotic interphase and their possible significance to meiotic chromosome pairing. Chromosoma, 26:410–426.

    Article  Google Scholar 

  • Walen, K. H. 1964. Somatic crossing over in relationship to heterochromatin in Drosophila melanogaster. Genetics, 49:905–923.

    PubMed  CAS  Google Scholar 

  • Walker, P. M. B. 1968. How different are the DNAs from related animals? Nature (London), 219:228–232.

    Article  CAS  Google Scholar 

  • Walker, P. M. B., 1969. The specificity of molecular hybridization in relation to studies on higher organisms. Progr. Nucl. Acid Res., 9:301–326.

    Article  CAS  Google Scholar 

  • Walker, P. M. B., and A. McLaren. 1965. Fractionation of mouse deoxyribonucleic acid on hydroxyapatite. Nature (London), 208:1175–1179.

    Article  CAS  Google Scholar 

  • Walker, P. M. B., W. G. Flamm, and A. McLaren. 1969. Highly repetitive DNA in rodents. In Handbook of Molecular Cytology, Lima-de- Faria, A., ed., Amsterdam & London, North-Holland Publishing Co., pp. 52–66.

    Google Scholar 

  • Wallace, M. E. 1953. Affinity: evidence from within laboratory stocks. Nature (London), 71:27–28.

    Article  Google Scholar 

  • Wallace, M. E., 1958. Experimental evidence for a new genetic phenomenon. Phil. Trans. Roy. Soc. London [Biol.], 241:211–254.

    Article  Google Scholar 

  • Wang, J. C, and N. Davidson. 1966. Thermodynamic and kinetic studies on the inter conversion between the linear and circular forms of phage lambda DNA. J. Molec. Biol., 15:111–123.

    Article  PubMed  CAS  Google Scholar 

  • Waring, M., and R. J. Britten. 1966. Nucleotide sequence repetition: A rapidly reassociating fraction of mouse DNA. Science, 154:791–794.

    Article  PubMed  CAS  Google Scholar 

  • Watts, R. L., and D. C. Watts. 1968. Gene duplication and the evolution of enzymes. Nature (London), 217:1125–1130.

    Article  CAS  Google Scholar 

  • Wells, R. D., and J. E. Blair. 1967. Studies of polynucleotides. LXXI. Sedimentation and buoyant density. Studies of some DNA-like polymers with repeating nucleotide sequences. J. Molec. Biol., 27:273–288.

    Article  PubMed  CAS  Google Scholar 

  • Westphal, H., and R. Dulbecco. 1968. Viral DNA in polyoma- and SV40-transformed cell lines. Proc. Nat. Acad. Sci. U.S.A., 59:1158–1165.

    Article  CAS  Google Scholar 

  • Wetmur, J. G., and N. Davidson. 1968. Kinetics of renaturation of DNA. J. Molec. Biol., 31:349–370.

    Article  PubMed  CAS  Google Scholar 

  • Whitehouse, H. L. K. 1967. A cycloid model for the chromosome. J. Cell Sci., 2:9–22.

    PubMed  CAS  Google Scholar 

  • Whiteley, A. H., B. J. McCarthy, and H. R. Whiteley. 1966. Changing populations of messenger RNA during sea urchin development. Proc. Nat. Acad. Sci. U.S.A., 55:519–525.

    Article  CAS  Google Scholar 

  • Williamson, R., and G. G. Brownlee. 1969. The sequence of 5S ribosomal RNA from two mouse cell lines. FEBS Letters, 3:306–308.

    Article  PubMed  CAS  Google Scholar 

  • Williamson, R., M. Morrison, and J. Paul. 1970. DNA- RNA hybridization of 9S messenger RNA for mouse globin. Biochem. Biophys. Res. Commun., 40:740–745.

    Article  PubMed  CAS  Google Scholar 

  • Wolff, S. 1969. Strandedness of chromosomes. Int. Rev. Cytol., 25:279–296.

    Article  PubMed  CAS  Google Scholar 

  • Wu, R. 1970. Nucleotide sequence analysis of DNA. I. Partial sequence of the cohesive ends of bacteriophage λ and 186 DNA. J. Molec. Biol., 51:501–521.

    Article  PubMed  CAS  Google Scholar 

  • Yankofsky, S. A., and S. Spiegelman. 1962. The identification of the ribosomal RNA cistron by sequence complementarity. II. Saturation of and competitive interaction at the RNA cistron. Proc. Nat. Acad. Sci. U.S.A., 48:1466–1472.

    Article  CAS  Google Scholar 

  • Yankofsky, S. A., and S. Spiegelman. 1963. Distinct cistrons for the two ribosomal RNA components. Proc. Nat. Acad. Sci. U.S.A., 49:538–544.

    Article  CAS  Google Scholar 

  • Yasmineh, W. G. and J. J. Yunis. 1970. Localization of mouse satellite DNA in constitutive heterochromatin. Exp. Cell. Res., 59:69–75.

    Article  PubMed  CAS  Google Scholar 

  • Yasmineh, W. G., and J. J. Yunis. 1971. Satellite DNA in calf heterochromatin. Exp. Cell Res. (In Press.)

    Google Scholar 

  • Yunis, J. J., and W. G. Yasmineh. 1970. Satellite DNA in constitutive heterochromatin of the guinea pig. Science, 168:263–265.

    Article  PubMed  CAS  Google Scholar 

  • Zehavi-Willner, T., and D. G. Comb. 1966. Studies on the relationship between transfer RNA and transfer-like RNA. J. Molec. Biol., 16:250–254.

    Article  PubMed  CAS  Google Scholar 

  • Zinder, N. D., and J. Lederberg. 1952. Genetic exchange in Salmonella. J. Bact. 64:679–699.

    Article  PubMed  CAS  Google Scholar 

  • Hill, R. L., R. Delaney, R. E. Fellows, Jr., and H. E. Lebovitz. 1966. The evolutionary origins of the immunoglobulins. Proc. Nat. Acad. Sci. U.S.A., 56:1762–1769.

    Article  CAS  Google Scholar 

  • Hilse, K., and R. A. Popp. 1968. Gene duplication as the basis for amino acid ambiguity in the alpha-chain polypeptides of mouse hemoglobins. Proc. Nat. Acad. Sci. U.S.A., 61:930–936.

    Article  CAS  Google Scholar 

  • Hinegardner, R. 1968. Evolution of cellular DNA content in teleost fishes. Amer. Naturalist, 102:517–523.

    Article  Google Scholar 

  • Holliday, R. 1968. Genetic recombination in fungi. In Replication and Recombination of Genetic Material, Peacock, W. J., and R. D. Brock, eds., Canberra, Australian Academy of Science, pp. 157–174.

    Google Scholar 

  • Hotta, Y., M. Ito, and H. Stern. 1966. Synthesis of DNA during meiosis. Proc. Nat. Acad. Sci. U.S.A., 56:1184–1191.

    Article  CAS  Google Scholar 

  • Hoyer, B. H., B. J. McCarthy, and E. T. Bolton. 1964. A molecular approach in the systematics of higher organisms. Science, 144:959–967.

    Article  CAS  Google Scholar 

  • Huang, R-C. C, and J. Bonner. 1965. Histone-bound RNA, a component of native nucleohistone. Proc. Nat. Acad. Sci. U.S.A., 54:960–967.

    Article  CAS  Google Scholar 

  • Huang, R-C. C, and P. C. Huang. 1969. Effect of protein-bound RNA associated with chick embryo chromatin on template specificity of the chromatin. J. Molec. Biol., 39:365–378.

    Article  PubMed  CAS  Google Scholar 

  • Huberman, J. A., and G. Attardi. 1967. Studies of fractionated HeLa cell metaphase chromosomes. I. The chromosomal distribution of DNA complementary to 28S and 18S ribosomal RNA and to cytoplasmic messenger RNA. J. Molec. Biol., 29:487–505.

    Article  CAS  Google Scholar 

  • Huberman, J. A., and A. D. Riggs. 1968. On the mechanism of DNA replication in mammalian chromosomes. J. Molec. Biol., 32:327–341.

    Article  PubMed  CAS  Google Scholar 

  • Jeanteur, P. H., and G. Attardi. 1969. Relationship between HeLa cell ribosomal RNA and its precursors studied by high resolution RNA-DNA hybridization. J. Molec. Biol., 45:305–324.

    Article  PubMed  CAS  Google Scholar 

  • John, B., and K. R. Lewis. 1968. The chromosome complement. Protoplasmatologia. VIA. Wien, Springer- Verlag.

    Book  Google Scholar 

  • John, H. A., M. L. Birnstiel, and K. W. Jones. 1969. RNA-DNA hybrids at the cytological level. Nature (London), 223:582–587.

    Article  CAS  Google Scholar 

  • Jones, K. W. 1970. Chromosomal and nuclear location of mouse satellite DNA in individual cells. Nature (London), 225:912–915.

    Article  CAS  Google Scholar 

  • Kates, J. 1970. Transcription of the vaccinia virus genome and the occurrence of polyriboadenylic acid sequences in messenger RNA. Cold Spring Harbor Symp. Quant. Biol. (In Press.)

    Google Scholar 

  • Kates, J., and J. Beeson. 1970. Ribonucleic acid synthesis in vaccinia virus. II. Synthesis of polyriboadenylic acid. J. Molec. Biol., 50:19–33.

    Article  PubMed  CAS  Google Scholar 

  • Keyl, H. -G. 1965a. Duplikationen von Untereinheiten der Chromosomalen DNS wahrend der Evolution von Chironomys thummi. Chromosoma 17:139–180.

    Article  PubMed  CAS  Google Scholar 

  • Keyl, H. -G., 1965b. A demonstrable local and geometric increase in the chromosomal DNA of Chironomus. Experientia, 21:191–193.

    Article  PubMed  CAS  Google Scholar 

  • Kimura, M. 1968. Evolutionary rate at the molecular level. Nature (London), 217:624–626.

    Article  CAS  Google Scholar 

  • Kingsbury, D. T. 1969. Estimate of the genome size of various microorganisms. J. Bact., 98:1400–1401.

    PubMed  CAS  Google Scholar 

  • Kit, S. 1961. Equilibrium sedimentation in density gradients of DNA preparations from animal tissues. J. Molec. Biol., 3:711–716.

    Article  PubMed  CAS  Google Scholar 

  • Kohne, D. E. 1968. Isolation and characterization of bacterial ribosomal RNA cistrons. Carnegie Inst. Year Book, 67:310–320.

    Google Scholar 

  • Kuempel, P. L. 1970. Bacterial chromosome replication. In Advances in Cell Biology, Prescott, D. M., L. Goldstein, and E. McConkey, eds., New York, Appleton-Century-Crofts, Vol. 1, pp. 3–56.

    Chapter  Google Scholar 

  • Kurnick, N. B., and I. H. Herskowitz. 1952. The estimation of polyteny in Drosophila salivary gland nuclei based on determination of DNA content. J. Cell Comp. Physiol., 39:281–299.

    Article  CAS  Google Scholar 

  • Laird, C. D. 1971. Chromatid structure: Relationship between DNA content and nucleotide sequence diversity. Chromosoma (in press).

    Google Scholar 

  • Laird, C. D., and B. J. McCarthy. 1969. Molecular characterization of the Drosophila genome. Genetics, 63: 865–882.

    PubMed  CAS  Google Scholar 

  • Langan, T. A., and L. Smith. 1966. The effect of a phosphoprotein preparation from liver nuclei on the inhibition of RNA synthesis by histones. Fed. Proc. 25:778.

    Google Scholar 

  • Lee, J. C, and J. J. Yunis. 1971. A developmental study of constitutive heterochromatin in Microtus agrestis. Chromosoma. (In Press.)

    Google Scholar 

  • Lim, L., and E. S. Canellakis. 1970. Adenine-rich polymer associated with rabbit reticulocyte messenger RNA. Nature (London), 227:710–712.

    Article  CAS  Google Scholar 

  • Lima-de-Faria, A., M. Birnstiel, and H. Jaworska. 1969. Amplification of ribosomal cistrons in the heterochromatin of Acheta. Genetics 61 (Suppl.): 145–159.

    PubMed  CAS  Google Scholar 

  • Lima-de-Faria, A., A., B. Nilsson, D. Cave, A. Puga, and H. Jaworska. 1968. Tritium labeling and cytochemistry of extra DNA in Acheta. Chromosoma, 25:1–20.

    Article  PubMed  CAS  Google Scholar 

  • MacHattie, L. A., D. A. Ritchie, C. A. Thomas, Jr., and C. C. Richardson. 1967. Terminal repetition in permuted T2 bacteriophage DNA molecules. J. Molec. Biol., 23:355–363.

    Article  PubMed  CAS  Google Scholar 

  • Madison, J. T. 1968. Primary structure of RNA. Ann. Rev. Biochem. 37:131–148.

    Article  PubMed  CAS  Google Scholar 

  • Maio, J. J., and C. L. Schildkraut. 1969. Isolated mammalian metaphase chromosomes. II. Fractionated chromosomes of mouse and Chinese hamster cells. J. Molec. Biol., 40:203–216.

    Article  PubMed  CAS  Google Scholar 

  • Mangiarotti, G., D. Apirion, D. Schlessinger, and L. Silengo. 1968. Biosynthetic precursors of 30S and 50S ribosomal particles in Escherichia coli. Biochemistry, 7:456–472.

    Article  PubMed  CAS  Google Scholar 

  • Mantieva, V. L., and V. Y. Arion. 1969. Influence of ultraviolet irradiation on transcription. (Translation) Molec. Biol. U.S.S.R., 3:294–302.

    Google Scholar 

  • Marin, G., and D. M. Prescott. 1964. The frequency of sister chromatid exchanges following exposure to varying doses of H3- thymidine or X-rays. J. Cell Biol., 21:159–167.

    Article  PubMed  CAS  Google Scholar 

  • Marmur, J., and P. Doty. 1959. Heterogeneity in deoxyribonucleic acids. I. Dependence on composition of the configurational stability of deoxyribonucleic acids. Nature (London), 183:1427–1429.

    Article  CAS  Google Scholar 

  • Marmur, J., and D. Lane. 1960. Strand separation and specific recombination in deoxyribonucleic acids: Biological studies. Proc. Nat. Acad. Sci. U.S.A., 46:453–461.

    Article  CAS  Google Scholar 

  • Marmur, J., R. Rownd, and C. L. Schildkraut 1963, Denaturation and renaturation of deoxyribonucleic acid, Progr. Nucl, Acid Res. 1:231–300.

    CAS  Google Scholar 

  • Marshall, R. E., C. T. Caskey, and M. Nirenberg. 1967. Fine structure of RNA codewords recognized by bacterial, amphibian, and mammalian transfer RNA. Science, 155:820–826.

    Article  PubMed  CAS  Google Scholar 

  • Martin, P. G., and R. Shanks. 1966. Does Vicia faba have multi-stranded chromosomes? Nature (London), 211:650–651.

    Article  Google Scholar 

  • Massaro, E. J., and C. L. Markert. 1968. Isozyme patterns of salmonid fishes: Evidence or multiple cistrons for lactate dehydrogenase polypeptides. J. Exp. Zool., 68:223–238.

    Article  Google Scholar 

  • Mattoccia, E., and D. E. Comings. 1970. The buoyant density and satellite composition of DNA of mouse heterochromatin. Nature (London). New Biol., 229:175–176.

    Google Scholar 

  • Mazrimas, J. A., and F. T. Hatch. 1970. Intranuclear distribution of satellite DNA from kangaroo rat. Exp. Cell Res., 63:462–466.

    Article  PubMed  CAS  Google Scholar 

  • McCarthy, B. J., and R. B. Church. 1970. The specificity of molecular hybridization reactions. Ann. Rev. Biochem., 39:131–150.

    Article  PubMed  CAS  Google Scholar 

  • McCarthy, B. J., and B. H. Hoyer. 1964. Identity of DNA and diversity of messenger RNA molecules in normal mouse tissues. Proc. Nat. Acad. Sci. U.S.A., 52:915–922.

    Article  CAS  Google Scholar 

  • McCarthy, B. J., R. W. Shearer, and R. B. Church. 1969. The unstable nuclear RNA of mammalian cells. In Problems in Biology: RNA in Development, Hanly, E. W., ed., Salt Lake City, University of Utah Press, pp. 285–312.

    Google Scholar 

  • McLaren, A., and P. M. B. Walker. 1968. The comparison of closely related groups of rodents by DNA/DNA annealing. Genet. Res., 12:117–124.

    Article  PubMed  CAS  Google Scholar 

  • Mego, W. A., D. P. Evenson, and J. H. Taylor. 1970. DNA subunits in replication and transcription. Biophys. Soc. Abstr. 160a.

    Google Scholar 

  • Michie, D. 1953. Affinity: A new genetic phenomenon in the house mouse. Nature (London), 71:26.

    Article  Google Scholar 

  • Michie, D. 1955. ‘Affinity’. Proc. Roy. Soc. London [Biol.], 144:241–259.

    Article  CAS  Google Scholar 

  • Miller, O. L., Jr., 1965. Fine structure of lampbrush chromosomes. Nat. Cancer Inst. Monogr. 18:79–99.

    PubMed  Google Scholar 

  • Miller, O. L., Jr., 1966, Structure and composition of periferal nucleoli of salamander oocytes. In International Symposium on the Nucleolus- Its Structure and Function, Vincent, W. S., and O. L. Miller, eds. Nat. Cancer Inst. Mongr., 23:53–66.

    Google Scholar 

  • Miller, O. L., Jr., and B. R. Beatty. 1969. Visualization of nucleolar gene. Science, 164:955–957.

    Article  PubMed  Google Scholar 

  • Miller, O. L., Jr., B. R. Beatty, B. A. Hamkalo, and C. A. Thomas, Jr. 1971. Electron microscope visualization of transcription. Cold Spring Harbor Symp. Quant. Biol. (In Press.)

    Google Scholar 

  • Mirsky, A. E., and H. Ris. 1951. The deoxyribonucleic acid content of animal cells and its evolutionary significance. J. Gen. Physiol., 34:451–462.

    Article  PubMed  CAS  Google Scholar 

  • Miyazawa, Y., and C. A. Thomas, Jr. 1965. Nucleotide composition of short segments of DNA molecules. J. Molec. Biol., 11:223–237.

    Article  PubMed  CAS  Google Scholar 

  • Moore, R. L., and B. J. McCarthy. 1968. Related base sequences in the DNA of simple and complex organisms. III. Variability in the base sequence of the reduplicated genes for ribosomal RNA in the rabbit. Biochem. Genet., 2:75–86.

    CAS  Google Scholar 

  • Morell, P., I. Smith, D. Dubnau, and J. Marmur. 1967. Isolation and characterization of low molecular weight ribonucleic acid species from Bacillus subtilis. Biochemistry, 6:258–265.

    Article  PubMed  CAS  Google Scholar 

  • Nei, M. 1969. Gene duplication and nucleotide substitution in evolution. Nature (London), 221:40–42.

    Article  CAS  Google Scholar 

  • Nygaard, A. P., and B. D. Hall. 1964. Formation and properties of RNA-DNA complexes. J. Molec. Biol., 9:125–142.

    Article  PubMed  CAS  Google Scholar 

  • Ohno, S., W. D. Kaplan, and R. Kinosita. 1957. Heterochromatic regions and nucleolus organizers in chromosomes of the mouse, Mus musculus. Exp. Cell Res., 13:358–364.

    Article  PubMed  CAS  Google Scholar 

  • Ohno, S., U. Wolf, and N. B. Atkin. 1968. Evolution from fish to mammals by gene duplication. Hereditas (Lund) 59:169–187.

    Article  CAS  Google Scholar 

  • Oishi, M., A. Oishi, and N. Sueoka. 1966. Location of genetic loci of soluble RNA on Bacillus subtilis chromosome. Proc. Nat. Acad. Sci. U.S.A., 55:1095–1103.

    Article  CAS  Google Scholar 

  • Okada, S. 1968. Replicating units (replicons) of DNA in cultured mammalian cells. Biophys. J., 8:650–664.

    Article  PubMed  CAS  Google Scholar 

  • Ostergren, G. 1945. Parasitic nature of extra fragment chromosomes. Botaniska Notiser, pp. 98:157–163.

    Google Scholar 

  • Painter, R. B., D. A. Jermany, and R. E. Rasmussen. 1966. A method to determine the number of DNA replicating units in cultured mammalian cells. J. Molec. Biol., 17:47–55.

    Article  PubMed  CAS  Google Scholar 

  • Pardue, M. L., and J. G. Gall. 1970. Chromosomal localization of mouse satellite DNA. Science, 168:1356–1358.

    Article  PubMed  CAS  Google Scholar 

  • Pardue, M. L., S. A. Gerbi, R. A. Eckhardt, and J. G. Gall. 1970. Cytological localization of DNA complementary to ribosomal RNA in polytene chromosomes of Diptera. Chromosoma, 29:268–298.

    Article  Google Scholar 

  • Patterson, J. T., and W. S. Stone. 1952. Evolution in the Genus Drosophila. New York, The MacMillan Company.

    Google Scholar 

  • Paul, J., and R. S. Gilmour. 1968. Organ-specific restriction of transcription in mammalian chromatin. J. Molec. Biol., 34:305–316.

    Article  PubMed  CAS  Google Scholar 

  • Penman, S., C. Vesco, and M. Penman. 1968. Localization and kinetics of formation of nuclear heterodisperse RNA, cytoplasmic heterodisperse RNA and polyribo some-associated messenger RNA in HeLa cells. J. Molec. Biol., 34:49–69.

    Article  PubMed  CAS  Google Scholar 

  • Plaut, W. 1969. On ordered DNA replication in polytene chromosomes. Genetics, 61: (Suppl.):239–244.

    PubMed  CAS  Google Scholar 

  • Polli, E., G. Corneo, E. Ginelli, and P. Bianchi. 1965. Fractionation of calf thymus deoxyribonucleic acid by density gradient centrifugation. Biochim. Biophys. Acta, 103:672–677.

    Article  PubMed  CAS  Google Scholar 

  • Prescott, D. M. 1970. The structure and replication of eukaryotic chromosomes. In Advances in Cell Biology, Prescott, D. M., L. Goldstein, and E. McConkey, eds., New York, Appleton-Century- Crofts, Vol. 1, pp. 57–117.

    Chapter  Google Scholar 

  • Pritchard, R. H. 1955. The linear arrangment of a series of alleles in Aspergillus nidulans. Heredity, 9:343–371.

    Article  Google Scholar 

  • Zuckerkandl, E., and L. Pauling. 1965. Evolutionary divergence and convergence in proteins. In Evolving Genes and Proteins, Bryson, V. and H. J. Vogel, eds., New York & London, Academic Press, Inc., pp. 97–166.

    Google Scholar 

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Authors and Affiliations

  1. Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA

    Christopher Bostock

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  1. Christopher Bostock
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  1. Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA

    David M. Prescott

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Bostock, C. (1971). Repetitious DNA. In: Prescott, D.M. (eds) Advances in Cell Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9588-5_4

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  • DOI: https://doi.org/10.1007/978-1-4615-9588-5_4

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