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Role of Dietary Antioxidants in Protection against Oxidative Damage

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Antimutagenesis and Anticarcinogenesis Mechanisms II

Part of the book series: Basic Life Sciences ((BLSC,volume 52))

Abstract

Recently, much attention has been focused on studies which suggest the involvement of active oxygens and free radicals in a variety of pathological events, cancer, and even the aging process (21,30). Oxygen is indispensable for aerobic organisms including, of course, human beings; however, it is believed that oxygen also may be responsible for undesired phenomena (4). In particular, oxygen species such as hydrogen peroxide, superoxide anion radical and singlet oxygen, and other radicals, are proposed as agents attacking polyunsaturated fatty acid in cell membranes, giving rise to lipid peroxidation (3). Several reports have suggested that lipid peroxidation may result in destabilization and disintegration of cell membranes, leading to liver injury and other diseases, and finally, to aging and susceptibility to cancer. However, normal cell membranes do not undergo lipid peroxidation so severely in vivo because of the extremely efficient protective mechanisms against damage caused by active oxygens and free radicals. Such systems include enzymatic inactivation by, for example, superoxide dismutase, glutathione-peroxidase and catalase, as well as nonenzymatic protection of polyunsaturated fatty acid by physiological and biological antioxidants such as vitamin E, vitamin C, ß-carotene, and uric acid (2). More recently, bilirubin (35) and carnocine (18) have been reported as being biologically significant antioxidants. In addition, several antioxidants have been reported to play an important role in the prevention of carcinogenesis related to active oxygen radicals, and in some cases, to extend the life span of animals (8).

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References

  1. Akasaka, S., and S. Yonei (1985) Mutation induction in Escherichia coli incubated in the reaction mixture of NADPH-dependent lipid peroxidation of rat-liver microsomes. Mutat. Res. 149:321–326.

    Article  PubMed  CAS  Google Scholar 

  2. Ames, B.N., R. Cathcart, E. Schwiers, and P. Hochstein (1981) Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging cancer: A hypothesis. Proc. Natl. Acad. Sci., USA 78:6858–6862.

    Article  PubMed  CAS  Google Scholar 

  3. Aust, S.D., and B.A. Svingen (1982) The role of ion in enzymatic lipid peroxidation. In Free Radicals in Biology, Vol. V, W.A. Pryor, ed. Academic Press, Inc., New York.

    Google Scholar 

  4. Balentino, D.B. (1982) Pathology of Oxygen Toxicity, Academic Press, Inc., New York.

    Google Scholar 

  5. Bauernfeind, J. (1980) Tocopherols in foods. In Vitamin E : A Comprehensive Treatise, Marcel Dekker, Inc., New York, pp. 99–167.

    Google Scholar 

  6. Cajelli, E., A. Ferraris, and G. Brambilla (1987) Mutagenicity of 4-hydroxynonenal in V79 Chinese hamster cells. Mutat. Res. 190:169–171.

    Article  PubMed  CAS  Google Scholar 

  7. Chiù, D., B. Lubin, and S.B. Shohet (1982) Peroxidative reactions in red cell biology. In Free Radicals in Biology, Vol. V, W.A. Pryor, ed. Academic Press, Inc., New York, pp. 115–160.

    Google Scholar 

  8. Cutler, R.G. (1984) Antioxidants, aging, and longevity. In Free Radicals in Biology, Vol. VI, W.A. Pryor, ed. Academic Press, Inc., New York, pp. 371–428.

    Google Scholar 

  9. Dianzani, M.U. (1982) Biochemical effects of saturated and unsaturated aldehydes. In Free Radicals, Lipid Peroxidation, and Cancer, D.C.H. McBrien and T.F. Slater, eds. Academic Press, Inc., New York, pp. 129–171.

    Google Scholar 

  10. Dugan, L.R. (1980) Natural antioxidants. In Autoxidation in Food and Biological Systems, M.G. Simic and H. Karel, eds. Plenum Press, New York, pp. 261–282.

    Google Scholar 

  11. Esterbauer, H. (1982) Aldehydic products of lipid peroxidation. In Free Radicals, Lipid Peroxidation, and Cancer, D.C.H. Mcbrien and T.F. Slater, eds. Academic Press, Inc., New York, pp. 101–128.

    Google Scholar 

  12. Esterbauer, H., K.H. Cheeseman, M.U. Dianzani, G. Poli, and T.F. Slater (1982) Separation and characterization of Jthe aldehydic products of lipid peroxidation stimulated by ADP-Fe in rat liver microsomes. Biochem. J. 208:129–140.

    PubMed  CAS  Google Scholar 

  13. Fukuda, Y., T. Osawa, and M. Namiki (1981) Antioxidants in sesame seed. Nippon Shokuhin Kogyo Gakkaishi 28:461–464.

    Article  CAS  Google Scholar 

  14. Fukuda, Y., T. Osawa, M. Namiki, and T. Ozaki (1985) Studies on antioxidative substances in sesame seed. Agric. Biol. Chem. 49:301–306.

    Article  CAS  Google Scholar 

  15. Fukuda, Y., M. Nagata, T. Osawa, and M. Namiki (1986) Contribution of lignan analogues to antioxidative activity of refined unroasted sesame seed oil. J. Am. Oil Chem. Soc. 63:1027–1031.

    Article  CAS  Google Scholar 

  16. Fukuda, Y., M. Isobe, M. Nagata, T. Osawa, and M. Namiki (1986) Acidic transformation of sesamolin, the sesame oil constituent into an antioxidant bisepoxylignan, sesaminol. Heterocycles 24:923–926.

    Article  CAS  Google Scholar 

  17. Hochstein, P., and A.H. Atallah (1988) The nature of oxidants and antioxidant systems in the inhibition of mutation and cancer. Mutat. Res. 202:363–375.

    Article  PubMed  CAS  Google Scholar 

  18. Kohen, R., Y. Yamamoto, K.C. Cundy, and B.N. Ames (1988) Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc. Natl. Acad. Sci., USA 85:3175–3179.

    Article  PubMed  CAS  Google Scholar 

  19. Lyon, O.K. (1972) Sesame: Current knowledge of composition and use. J. Am. Oil Chem. Soc. 49:245–249.

    Article  CAS  Google Scholar 

  20. Marnett, L.J., H.K. Hurd, M.C. Hollstein, D.E. Levin, H. Esterbauer, and B.N. Ames (1985) Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104. Mutat. Res. 148:25–34.

    Article  PubMed  CAS  Google Scholar 

  21. McBrien, D.C.H., and T.F. Slater, eds. (1982) Free Radicals, Lipid Peroxidation and Cancer, Academic Press, Inc., New York.

    Google Scholar 

  22. McCay, P.B., and M.M. King (1980) Vitamin E: Its role as a biological free radical scavenger and its relationship to the microsomal mixed-function oxidase system. In Vitamin E: A Comprehensive Treatise, L.J. Mcchlin, ed. Marcel Dekker, Inc., New York, pp. 289–317.

    Google Scholar 

  23. Mukai, F.H., and B.D. Goldstein (1976) Mutagenicity of malonaldehyde, a decomposition product of peroxidized polyunsaturated fatty acids. Science 191:868–869.

    Article  PubMed  CAS  Google Scholar 

  24. Nagata, M., T. Osawa, M. Namiki, Y. Fukuda, and T. Ozaki (1987) Stereochemical structures of antioxidative bisepoxylignans, sesaminol and its isomers, transformed from sesamolin. Agric. Biol. Chem. 51:1285–1289.

    Article  CAS  Google Scholar 

  25. Namiki, M., and T. Osawa (1986) Antioxidants/antimutagens in foods. In Antimutagenesis and Anticarcinogenesis Mechanisms, D.M. Shankel, P.E. Hartman, T. Kada, and A. Hollaender, eds. Plenum Press, New York, pp. 131–142.

    Google Scholar 

  26. Ohta, T., K. Watanabe, M. Moriya, Y. Shirasu, and T. Kada (1983) Anti-mutagenic effects of coumarin and umbelliferone on mutagenesis induced by 4-nitroquinoline 1-oxide or UV irradiation in E. coli. Mutat. Res. 117:135–138.

    Article  CAS  Google Scholar 

  27. Osawa, T., M. Nagata, M. Namiki, and Y. Fukuda (1985) Sesamolinol, a novel antioxidant isolated from sesame seeds. Agric. Biol. Chem. 49:3351–3352.

    Article  CAS  Google Scholar 

  28. Osawa, T., A. Ide, J.-De Su, and M. Namiki (1987) Inhibition of lipid peroxidation by ellagic acid. J. Agric. Food Chem. 35:808–812.

    Article  CAS  Google Scholar 

  29. Porter, W.L. (1980) Recent trend in food applications of antioxidants. In Autoxidation in Food and Biological Systems, M.G. Simic and M. Karel, eds. Plenum Press, New York, pp. 295–365.

    Google Scholar 

  30. Pryor, W.A. (1986) Cancer and free radicals. In Antimutagenesis and Anticarcinogenesis Mechanisms, D.M. Shankel, P.E. Hartman, T. Kada, and A. Hollaender, eds. Plenum Press, New York, pp. 45–59.

    Google Scholar 

  31. Pziezak, J.D. (1986) Preservatives: Antioxidants. The ultimate answer to oxidation. Food Tech. 40(9) : 94–102.

    Google Scholar 

  32. Shima, A. (1988) Effect of food components on cellular aging. In Food Functionalities, M. Fujimaki, ed. Gakkai Press Center, Tokyo, pp. 227–231.

    Google Scholar 

  33. Shimoi, K., Y. Nakamura, I. Tomita, Y. Hara, and T. Kada (1986) The pyrogallol related compounds reduce UV-induced mutations in Escherichia coli, B/r WP2. Mutat. Res. 173:239–244.

    Article  PubMed  CAS  Google Scholar 

  34. Simic, M.G. (1988) Mechanisms of inhibition of free-radical processes in mutagenesis and carcinogenesis. Mutat. Res. 202:377–386.

    Article  PubMed  CAS  Google Scholar 

  35. Stocker, R., Y. Yamamoto, A.F. McDonagh, A.N. Glazer, and B.N. Ames (1987) Bilirubin is an antioxidant of possible physiological importance. Science 235:1043–1046.

    Article  PubMed  CAS  Google Scholar 

  36. Su, J.-De, T. Osawa, and M. Namiki (1986) Screening for antioxidative activity of crude drugs. Agric. Biol. Chem. 50:199–203.

    Article  CAS  Google Scholar 

  37. Su, J.-De, T. Osawa, S. Kawakishi, and M. Namiki (1987) Antioxidative flavonoids isolated from Osbeckia chinensis L. Agric. Biol. Chem. 51:2801–2803.

    Article  CAS  Google Scholar 

  38. Su, J.-De, T. Osawa, S. Kawakishi, and M. Namiki (1987) A novel antioxidative synergist isolated from Osbeckia chinensis L. Agric. Biol. Chem. 51:3449–3450.

    Article  CAS  Google Scholar 

  39. Su, J.-De, T. Osawa, S. Kawakishi, and M. Namiki (1988) Tannin antioxidants from Osbeckia chinensis. Phytochemistry 27:1315–1319.

    Article  CAS  Google Scholar 

  40. Yonei, S., and H. Furui (1981) Lethal and mutagenicity effects of malonaldehyde, a decomposition product of peroxidized lipids, on Escherichia coli with different DNA repair capacities. Mutat. Res. 88:23–32.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Food Science and Technology, Nagoya University, 464-01, Chikusa, Nagoya, Japan

    Toshihiko Osawa, Mitsuo Namiki & Shunro Kawakishi

Authors
  1. Toshihiko Osawa
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  2. Mitsuo Namiki
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  3. Shunro Kawakishi
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Editor information

Editors and Affiliations

  1. National Institute of Genetics, Mishima, Japan

    Yukiaki Kuroda

  2. University of Kansas, Lawrence, Kansas, USA

    Delbert M. Shankel

  3. United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Michael D. Waters

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© 1990 Plenum Press, New York

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Osawa, T., Namiki, M., Kawakishi, S. (1990). Role of Dietary Antioxidants in Protection against Oxidative Damage. In: Kuroda, Y., Shankel, D.M., Waters, M.D. (eds) Antimutagenesis and Anticarcinogenesis Mechanisms II. Basic Life Sciences, vol 52. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9561-8_11

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  • DOI: https://doi.org/10.1007/978-1-4615-9561-8_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9563-2

  • Online ISBN: 978-1-4615-9561-8

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