Abstract
T-lymphocytes play a crucial role in the defense mechanism of higher organisms against harmful agents, such as viruses, bacteria, parasites and tumors. There is ample evidence that soluble products released by specifically induced T-effector cells such as interleukins (1) and lympholysins (2) are operative directly and/or indirectly in various defense mechanisms.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
T. Kishimoto, Factors affecting B-cell growth and differentiation, Ann. Rev Immunol. 3: 133 (1987).
H. S. Koren, Proposed classification of leukocyte-associated cytolytic molecules, Immunol. Today, 8: 3 (1987).
T. W. Chang, and H. N. Eisen, Effects of N-α-Tosyl-L-Lysyl-Chloromethyl-ketone on the activity of cytotoxic T lymphocytes,. Immunol. 124: 1028 (1980).
D. Redelman, and D. Hudig, The mechanism of cell-mediated cytotoxicity. I. Killing by murine cytotoxic T lymphocytes requires cell sufrace thiols and activated proteases, J. Immunol. 124: 870 (1980)
T. L. Vischer, Stimulation of mouse B lymphocytes by trypsin, 3. Immunol. 113: 58(1974).
G. Kaplan, and C. Bona, Proteases as mitogens, Exp. Celles. 88: 388 (1974).
M. D. Kramer, L. Binninger, V. Schirrmacher, H. Moll, M. Prester, G. Nerz, and M.M. Simon, Characterization and isolation of a trypsin-like serine protease from a long-term culture cytolytic T cell line and its expression by functionally distinct T cells. Immunol. 136: 4644 (1986).
M. M. Simon, H. Hotschützky, U. Fruth, H.-G. Simon, and M. D. Kramer, Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes, EMBO J. 5: 3267 (1986).
U. Fruth, F. Sinigaglia, M. Schlesier, J. Kilgus, M. D. Kramer, and M. M. Simon, A novel serine proteinase (HuTSP) isolated from a cloned human CD8 cytolytic T cell line is expressed and secreted by activated CD4+ and CD8+ lymphocytes, Eur. J. Immunol., 17: 1625 (1987).
M. S. Pasternack, C.R. Verret, M. A. Liu, and H. N. Eisen, Serine esterase in cytolytic Tlymphocytes, Nature 322: 740 (1986).
D. Masson, M. Nabholz, C. Estrade, and J. Tschopp, Granules of cytolytic T-lymphocytes contain two serine esterases, EMBO J. 5: 1595 (1986).
J. D. E. Young, C. C. Liu, A. Damiano, D. A. Wall, and Z. A. Cohn, Isolation and characterization of a serine esterase from cytolytic Tcell granules, Cell 47: 183 (1986).
M. M. Simon, U. Fruth, H.-G. Simon, and M. D. Kramer, A specific serine proteinase is inducible in Lyt-2+, L3T4-and Lyt-2-, L3T4+ T cells in vitro but is mainly associated with Lyt-2+, L3T4-effector cells in vivo, Eur. J. Immunol. 16: 1559(1986).
H.-G. Simon, U. Fruth, R. Geiger, M. D. Kramer, and M. M. Simon, The T cell specific serine proteinase TSP-1. Biochemical characterization, genetic analysis and functional role. In: Advances in Experimental Biology and Medicine, in press.
U. Fruth, M. Prester, J.R. Golecki, H. Hengartner, H.-G. Simon, M. D. Simon, and M. M. Simon, The T cell specific serine proteinase TSP-1 is associated with cytoplasmic granules of cytolytic T lymphocytes, Eur. J. Immunol. 17: 613 (1987).
M. M. Simon, U. Fruth, H.-G. Simon, and M. D. Kramer, Evidence for the involvement of a T cell associated serine proteinase (TSP-1) in cell killing, 17th orum in Immunol. Ann. Inst. Pasteur, 138: 285 (1987).
H.-G. Simon, U. Fruth, M. D. Kramer, and M. M. Simon, A secretable serine proteinase with highly restricted specificity from cytolytic T lymphocytes inactivates retrovirus associated reverse transcriptase. FEBS etters, 223: 352 (1987).
M. M. Simon, H.-G. Simon, U. Fruth, D. Epplen, H. K. Müller-Hermelink, and M. D. Kramer, Cloned cytolytic T-effector cells and their malignant variants produce and extracellular matrix degrading trypsin-like serine proteinase. Immunol. 60: 219 (1987).
M. M. Simon, M. Prester, G. Nerz, M. D. Kramer, and U. Fruth, Release of biologically active fragments from human plasma fibronectin by murine T cell specific proteinase 1 (TSP-1), Biol. Chem. Hoppe eyier, in press.
M. D. Kramer, and M. M. Simon, Are proteinases functional molecules of T lymphocytes> Immunol. Today, 8: 140 (1987).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Simon, M.M., Fruth, U., Simon, HG., Gay, S., Kramer, M.D. (1989). Evidence for Multiple Functions of T-Lymphocytes Associated Serine Proteinases. In: Abe, K., Moriya, H., Fujii, S. (eds) Kinins V. Advances in Experimental Medicine and Biology, vol 247 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9543-4_95
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9543-4_95
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9545-8
Online ISBN: 978-1-4615-9543-4
eBook Packages: Springer Book Archive