Abstract
The beneficial influence of calcium antagonists in the treatment of coronary heart disease, hypertension, etc., has been examined from various points of view in both, chronic and acute animal experiments (Henry, 1980; Holmes et al., 1984). However, there is little information concerning the effects of calcium antagonists on cerebrocortical surface PO2 (SPO2) and cerebral blood flow (CBF). In contrast to the generally accepted animal models simulating ischemia, hypertension, arteriosclerosis, etc., experiments have been performed near the metabolic equilibrium of the normal rat. This knowledge might be helpful in finding an adequate therapy for the ischemic patient and in learning more about the unexpected side-effects of the calcium antagonists.
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© 1988 Plenum Press, New York
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Metzger, H.P., Savas, Y. (1988). The Influence of the Calcium Antagonists Flunarizine and Verapamil on Cerebral Blood Flow and Oxygen Tension of Anesthetized WFS-Rats. In: Mochizuki, M., Honig, C.R., Koyama, T., Goldstick, T.K., Bruley, D.F. (eds) Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology, vol 222. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9510-6_49
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DOI: https://doi.org/10.1007/978-1-4615-9510-6_49
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