Skip to main content

Proteinases and their Inhibitors in Septicemia - Basic Concepts and Clinical Implications

  • Chapter
Proteases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 167))

Abstract

During the inflammatory response various systemic or local tissue cells are activated thereby releasing internal, mostly lysosomal enzymes. They trigger the activation of the clotting, fibrinolysis and complement cascades, the disrupture of cell membranes and tissue structures, and the release of toxic peptides (Fig. 1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. K. Havemann and A. Janoff: Neutral Proteases of Human Polymorphonuclear Leukocytes. Urban and Schwarzenberg Verlag, Baltimore-Munich (1978).

    Google Scholar 

  2. S.J. Klebanoff and R.A. Clark: The Neutrophil Function and Clinical Disorders. Elsevier/North-Holland Biomedical Press, Amsterdam, The Netherlands (1978).

    Google Scholar 

  3. R. Egbring, M. Gramse, N. Heimburger, K. Havemann: In vivo effects of human granulocyte neutral proteinases on blood coagulation in green monkeys (cercopithecus aetiops). 6th Int. Congr. Thromb. Hemostr. Philadelphia 1977, Abstr. Diath. Haemorrh. 38: 222 1977.

    Google Scholar 

  4. A.O. Aasen, K. Ohlsson, M. Larsbraaten, E. Amundsen: Changes in plasminogen levels, plasmin activity and activity of antiplasmin during endotoxin shock in dogs. Eur. surg. Res. 10: 63–72 (1978).

    Article  PubMed  CAS  Google Scholar 

  5. A.O. Aasen, K. Ohlsson: Release of granulocyte elastase in lethal canine endotoxin shock. Hoppe Sey-ler’s Z. Physiol. Chem. 359: 683–690 (1978).

    CAS  Google Scholar 

  6. R. Egbring, W. Schmidt, G. Fuchs, K. Havemann: Demonstration of granulocytic proteases in plasma of patients with acute leukemia and septicemia with coagulation defects. Blood 49: 219–231 (1977).

    PubMed  CAS  Google Scholar 

  7. A.O. Aasen, N. Smith-Erichsen, M.J. Gallimore, E. Amundsen: Studies on components of the plasma kallikrein-kinin system in plasma samples from normal individuals and patients with septic shock. Advances in Shock Res. 4: 1–10 (1980).

    CAS  Google Scholar 

  8. M. J. Gallimore, A.O. Aasen, K. Lyngaas, M. Larsbraaten, N. Smith-Erichsen, E. Amundsen: Studies on the coagulation and fibrinolytic systems in septicemia. Microvasc. Res. 18: 292 1979.

    Google Scholar 

  9. J. Witte, M. Jochum, R. Scherer, W. Schramm, K. Hochstrasser, H. Fritz: Disturbances of selected Plasma Proteins in Hyperdynamic Septic Shock. Intensive Care Med. 8: 215–222 (1982).

    Article  PubMed  CAS  Google Scholar 

  10. M. Jochum, S. Lander, N. Heimburger, H. Fritz: Effect of human granulocytic elastase on isolated human antithrombin III. Hoppe Seyler’s Z. Physiol. Chem. 362: 103–112 (1981).

    Article  PubMed  CAS  Google Scholar 

  11. M. J. Banda, E. J. Clark, Z. Werb: Limited proteolysis by macrophage elastase inactivated human α1-proteinase inhibitor. J. Exp. Med. 152: 1563–1570 (1980).

    Article  PubMed  CAS  Google Scholar 

  12. K. Beatty, J. Beith, J. Travis: Kinetics of association of serine proteinases with native and oxidized α1-proteinase inhibitor and α1-antichymotrypsin. J. Biol. Chem. 255: 3931–3934 (1980).

    PubMed  CAS  Google Scholar 

  13. S. Neumann, N. Hennrich, G. Gunzer, H. Lang: Enzyme-linked immunoassay for human granulocyte elastase α1-proteinase inhibitor complex. In: D.M. Goldberg and M. Werner (eds.) Progress in Clinical Enzymology-II, 1982 (in press) and this issue.

    Google Scholar 

  14. S. Ikematsu, R.P. McDonagh, H.M. Reisner, C. Skrzynia, J. McDonagh: Immunochemical studies of human factor XIII: Radioimmunoassay for the carrier subunit of the zymogen. J. Lab. Clin. Med. 97: 662–671 (1981).

    PubMed  CAS  Google Scholar 

  15. M. Jochum, J. Witte, H. Schiessler, H.K. Selbmann, G. Ruckdeschl, H. Fritz: Clotting and other plasma factors in experimental endotoxemia: Inhibition of degradation by exogenous proteinase inhibitors. Eur. surg. Res. 13: 152–168 (1981).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Jochum, M., Duswald, KH., Neumann, S., Witte, J., Fritz, H. (1984). Proteinases and their Inhibitors in Septicemia - Basic Concepts and Clinical Implications. In: Hörl, W.H., Heidland, A. (eds) Proteases. Advances in Experimental Medicine and Biology, vol 167. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9355-3_34

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9355-3_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9357-7

  • Online ISBN: 978-1-4615-9355-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics