Skip to main content
SpringerLink
Log in

Specific Features of Metal Absorption in Suckling Animals

  • Chapter
Reproductive and Developmental Toxicity of Metals

Abstract

The results obtained in rats and other animal species show differences in the pharmacokinetics and toxicity of lead, cadmium, mercury and manganese between suckling and weaned animals. Most of these differences are the result of specific features of metal metabolism in neonates: higher gastrointestinal absorption and lack of metal-metal interaction; different organ distribution, especially higher brain retention and higher gut retention of some metals. A higher acute toxicity, particularly after oral administration, is also likely to be the result of specific metal metabolism in this age group. These results indicate that the neonatal age represents a period of high risk for metal exposure.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bushnell, P.J. and DeLuca, H.F., 1981, Lactose facilitates the intestinal absorption of lead in weanling rats, Science 211: 61–63.

    Article  PubMed  CAS  Google Scholar 

  • Cain, K. and Webb, M., 1982, Metallothionein and its relationship to the toxicity of cadmium and other metals in the young, in: “Proceedings of the Symposium on the Health Evaluation of Heavy Metals in Infant Formula and Junior Food”, Berlin, 1981, (in press), Springer Verlag, Berlin.

    Google Scholar 

  • Deskin, R. Bursian, S.J. and Edens, F.W., 1980, Neurochemical alterations induced by manganese chloride in neonatal rats, Neurotoxicol. 2: 65.

    Google Scholar 

  • Engstrom, B. and Nordberg, G., 1978, Effects of milk diet on gastrointestinal absorption of cadmium in adult mice, Toxicol 9: 195.

    CAS  Google Scholar 

  • Gallagher, N.D., Mason, R. and Foley, K.E., 1973, Mechanism of iron absorption and transport in neonatal rat intestine, Gastroenterology 64: 438–444,

    Google Scholar 

  • Gruden, N.. 1980, Body retention and tissue distribution of 59Fe and 54Mn in newborn rats fed iron-supplemented cow’s milk, Reprod. Nutr. Develop. 20 (5A): 1539.

    Article  CAS  Google Scholar 

  • Inaba, J. and Lengemann, F.W., 1972, Intestinal uptake and whole body retention of 141Ce by suckling rats, Health Phys. 22: 169–175.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, D.R. and Foulkes, EX., 1980, On the proposed role of metal othionein in the transport of cadmium, Environ. Res. 21: 360–365.

    Google Scholar 

  • Jugo, S., 1976, Retention and distribution of 203Hg Cl2 in suckling and adult rats, Health Phys. 30: 240–241.

    PubMed  CAS  Google Scholar 

  • Jugo, S., Maljkovic, T. and Kostial, K., 1975a, The effect of chelating agents on lead excretion in rats in relation to age, Environ. Res. 10: 271.

    Article  CAS  Google Scholar 

  • Jugo, S., Maljkovic, T. and Kostial, K., 1975b, Influence of chelating agents on the gastrointestinal absorption of lead, Toxicol. Appl. Pharmacol. 34: 359–263.

    Article  Google Scholar 

  • Kello, D. and Kostial, K., 1973, The effect of milk on lead metabolism in rats, Environ. Res. 6: 355.

    Google Scholar 

  • Kello, D. and Kostial, K., 1977a, Influence of age and milk diet on cadmium absorption from the gut, Toxicol. Appl. Pharmacol. 40: 277–282.

    Article  CAS  Google Scholar 

  • Kello, D. and Kostial, K., 1977b, Influence of age on whole body retention and distribution in suckling and adult rats, Environ. Res. 14: 92–98.

    Google Scholar 

  • Kello, D. and Kostial, K., 1978, Lead and cadmium in hair as an indicator of body burden in rats of different age, Bull. Environ. Contam. Toxicol. 20: 618–623.

    Article  PubMed  CAS  Google Scholar 

  • Kello, D., Dekanic, D., Kostial, K., 1979a, Influence on sex and dietary calcium on intestinal cadmium absorption in rats, Arch. Environ. Health 34: 30–33.

    Google Scholar 

  • Kello, D., Sugawara, N., Voner, C. and Foulkes, E.C., 1979b, On the role of metallothionein in cadmium absorption by rat jejunum in situ, Toxicol. 14: 199–208.

    Article  CAS  Google Scholar 

  • Kirchgessner, M., Weigand, E. and Schwarz, F.J., 1981, Absorption of zinc and manganese in relation to age,: “Trace Elements in Man and Animals”, J. McHowell, J.J. Ganthorne, and C.L. White, p. 125, Australian Academy of Science, Camberra, Perth.

    Google Scholar 

  • Klein, A.W. and Koch, T.R., 1981, Lead accumulation in brain, blood and liver after low dosing in neonatal rats, Arch. Toxicol. 47: 257.

    Article  PubMed  CAS  Google Scholar 

  • Kostial, K., 1982, The absorption of heavy metals by the growing organism - experimental experience with animals, in: Proceedings of the Symposium on Health “Evaluation of Heavy Metals in Infant Formula and Junior Food”, Berlin 1981, (in press) Springer Verlag, Berlin.

    Google Scholar 

  • Kostial, K. and Kello, D., 1979, Bioavailability of lead in rats fed “human” diets, Bull, Environ, Contam. Toxicol. 21: 312–314.

    Article  CAS  Google Scholar 

  • Kostial, K., Simonovic, I. and Pi sonic, M., 1967, Effect of calcium phosphate on gastrointestinal absorption of strontium and calcium in newborn rats, Nature, London 215: 1181–1182.

    Google Scholar 

  • Kostial, K., Simonovic, I. and Pi sonic, M., 1971a, Lead absorption from the intestine in newborn rats, Nature, London 233: 561–564.

    Article  Google Scholar 

  • Kostial, K., Simonovic, I. and Pisonic, M., 1971b, Reduction of lead absorption from the intestine in newborn rats, Environ. Res. 4: 360.

    Google Scholar 

  • Kostial, K., Kello, D. and Harrison, G.E., 1973, Comparative metabolism of lead and calcium in young and adult rats, Int. Arch. Arbeitsmed. 31: 179.

    Google Scholar 

  • Kostial, K., Rabar, I., Blanusa, M. and Landeka, M., 1979a, Influence of age on heavy metal absorption, Proc. Nutr. Soc. 38: 251–256.

    Article  CAS  Google Scholar 

  • Kostial, K., Rabar, Ciganovic, M. and Simonovic, I., 1979b, Effect of milk on mercury absorption and gut retention in rats, Bull. Environ. Contam. Toxicol. 23: 566–571.

    Google Scholar 

  • Kostial, K., Rabar, I., Blanusa, M. and Ciganovic, M., 1980a, The influence of trace elements on cadmium and mercury absorption in sucklings, Bull.Environ. Contam. Toxicol. 23: 566–571.

    Google Scholar 

  • Kostial, K., Rabar, I., Blanusa, M. and Simonovic, I., 1980b, The effect of iron additive to milk on cadmium, mercury and manganese absorption in rats, Environ. Res. 22: 40–45.

    Google Scholar 

  • Kostial, K., Blanusa, M., Rabar, I. and Simonovic, I., 1981a, More data on mercury absorption in relation to dietary treatment in rats, Toxicol. Lett. 7: 201.

    Article  CAS  Google Scholar 

  • Kostial, K., Simonovic. I., Rabar, I. and Landeka, M., 1981b, Effect of rat’s diet on 85Sr, USmCd and 203Hg absorption in suckling rats, Environ. Res. 25: 281–285.

    Google Scholar 

  • Kostial, K., Kello, D., Jugo, S., Rabar, I and Maljkovic, T, 1978, The influence of age on metal metabolism and toxicity, Environ. Health Perspect. 25: 81–86.

    Article  PubMed  CAS  Google Scholar 

  • Kostial, K., Kello, D., Blanusa, M., Maljkovic, T. and Rabar, I., 1979, Influence of some factors on cadmium pharmacokinetics and toxicity, Environ. Health Perspect. 28: 89–95.

    Google Scholar 

  • Landry, T.D., Doherty, R.A. and Gates, A.H., 1979, Effects of three diets on mercury excretion after methylmercury administration, Bull. Environ. Contam. Toxicol. 2: 151–158.

    Google Scholar 

  • Maljkovic, T., 1982, Effect of coal gasifier ash on the toxicity of some metals, Ph.D. Thesis, University of Zagreb, Zagreb.

    Google Scholar 

  • McCabe, E.B., 1979, Age and sensitivity to lead toxicity: A review, Environ. Health Pferspect. 29: 29–33.

    Google Scholar 

  • Momcilovic, B., 1978, Effect of zinc added to milk on 65Zn absorption in newborn rats, Period, Biol 80: 141.

    CAS  Google Scholar 

  • Nordberg, G.F., Fowler, B.A., Friberg, L., Jernelov, A., Nelson, N., Piscator, M., Sanstead, H., Vostal, J. and Vouk, V.B., 1978, Factors influencing metabolism and toxicity of metals: a consensus report, Environ. Health Perspect 25: 3–41.

    Article  CAS  Google Scholar 

  • Quaterman, J. and Morrison, E., 1978, The effect of age on the absorption and excretion of lead, Environ. Res. 17: 78–83.

    Google Scholar 

  • Rabar, I., 1976, Effect of some factors on manganese metabolism in rats, M. Sc. Thesis, University of Zagreb, Zagreb.

    Google Scholar 

  • Rabar, I., and Kostial, K., 1981a, Bioavailability of cadmium in rats fed various diets, Arch. Toxicol. 47: 63.

    CAS  Google Scholar 

  • Rabar, I. and Kostial, K., 1981b, Failure of trace element to decrease cadmium, mercury and manganese absorption in suckling rats, in: Proceedings in Life Science: “Industrial and Environmental Xenobiotics - Metabolism and Pharmacokinetics of Organic Chemicals and Metals”, I. Gut, ed., p. 45, Springer Verlag, Berlin.

    Google Scholar 

  • Rehnberg, G.L., Hein, J.F., Carter, S.D. and Laskey, J.W., 1980, Chronic manganese accumulation and distribution, J. Toxicol. Environ. Health 6: 217–226.

    Article  PubMed  CAS  Google Scholar 

  • Richardson, M.E. and Fox, M.R.S., 1974, Dietary cadmium and enteropathy in the Japanese quail - histochemical and ultrastructural studies, Lab. Invest. 31: 722–731.

    Google Scholar 

  • Sasser, L.B. and Jarboe, G.E., 1977, Intestinal absorption and retention of cadmium in neonatal rat, Toxicol. Appl. Pharmacol. 41: 423–431.

    Google Scholar 

  • Sasser, L.B. and Jarboe, G.E., 1980, Intestinal absorption and retention of cadmium in neonatal pigs compared to rats and guinea pigs, J. Nutr. 110: 1641–1647.

    PubMed  CAS  Google Scholar 

  • Shiraishi, Y. and Ishikawa, R., 1972, Absorption and retention of 144Ce abnd 95Zr - 95Nb in newborn, juvenile and adult rats, Health Phys. 22: 373–378.

    Article  PubMed  CAS  Google Scholar 

  • Sikov, M.R. and Mahlum, D.D., 1972, Plutonium in the developing animal, Health Phys 22: 707–712.

    CAS  Google Scholar 

  • Thompson, W.P. and Weil, C.S., 1952, Tables for convenient calculation of median effective dose (LD50 or ED50) and instructions in their use, Biometrics 8: 249.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Medical Research and Occupational Health, Zagreb, Yugoslavia

    Krista Kostial

Authors
  1. Krista Kostial
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Toxicology Department of Radiation Biology and Biophysics, University of Rochester School of Medicine, Rochester, New York, USA

    Thomas W. Clarkson  & Polly R. Sager  & 

  2. Department of Environmental Medicine, University of Umea, Umea, Sweden

    Gunnar F. Nordberg

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Press, New York

About this chapter

Cite this chapter

Kostial, K. (1983). Specific Features of Metal Absorption in Suckling Animals. In: Clarkson, T.W., Nordberg, G.F., Sager, P.R. (eds) Reproductive and Developmental Toxicity of Metals. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9346-1_31

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9346-1_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9348-5

  • Online ISBN: 978-1-4615-9346-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation