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Mechanisms of Cerebrospinal Fluid Absorption in Normal and Pathologically Altered Arachnoid Villi

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Neurobiology of Cerebrospinal Fluid 2

Abstract

The cerebrospinal fluid (CSF) system, contained within the craniospinal cavities, may be described as a moderately distensible compartment enclosed by the skull and vertebral column, wherein CSF pressure is normally maintained within a relatively narrow range. Transient alterations in volume and flow are compensated by interactions between regulatory mechanisms that involve CSF formation, storage, and outflow. Volumetric expansion within the craniospinal cavities is spatially compensated by a combination of these interacting regulatory factors, which include (1) a compliance factor, defined in terms of volume change per unit change in CSF pressure56, 57, 61, 62 and functionally related to the elastic properties of craniospinal meninges and blood vessels; and (2) an outflow resistance factor that modulates CSF volume by venting fluid through CSF outflow sites into the venous circulation.

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Authors and Affiliations

  1. Department of Neurosurgery, State University of New York at Stony Brook, Stony Brook, New York, 11794, USA

    Albert B. Butler M.D.

  2. Department of Neurosurgery, Charlottesville, Virginia, 22908, USA

    Ralph G. Dacey Jr. M.D.

  3. Departments of Anesthesiology and Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia, 22908, USA

    Charles J. Maffeo Ph.D.

  4. Department of Neurology, Chapel Hill, North Carolina, 27514, USA

    J. Douglas Mann M.D.

  5. A. F. Fortune Biomedical Computer Center, Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27514, USA

    Richard N. Johnson Sc.D.

  6. Department of Neurology, University of Kentucky School of Medicine, Lexington, Kentucky, 40506, USA

    Norman H. Bass M.D.

Authors
  1. Albert B. Butler M.D.
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  2. Ralph G. Dacey Jr. M.D.
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  3. Charles J. Maffeo Ph.D.
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  4. J. Douglas Mann M.D.
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  5. Richard N. Johnson Sc.D.
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  6. Norman H. Bass M.D.
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Editor information

Editors and Affiliations

  1. Division of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA

    James H. Wood M D

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© 1983 Plenum Press, New York

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Butler, A.B., Dacey, R.G., Maffeo, C.J., Mann, J.D., Johnson, R.N., Bass, N.H. (1983). Mechanisms of Cerebrospinal Fluid Absorption in Normal and Pathologically Altered Arachnoid Villi. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9269-3_45

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  • DOI: https://doi.org/10.1007/978-1-4615-9269-3_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9271-6

  • Online ISBN: 978-1-4615-9269-3

  • eBook Packages: Springer Book Archive

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