Abstract
In a tumor therapy model with spontaneous mammary tumors in mongrel dogs (1) using Vibrio cholerae neuraminidase (VCN)-treated autologous tumor cells success has been shown to depend on the number of cells injected. Tumor enhancement (1 × 108 cells), long-lasting tumor regression (2 × 107 cells) or only a transient therapeutic effect (2 × 106 cells) could be demonstrated. Moreover, it has been shown that distinct amounts of active VCN remain attached to the cell surface of VCN-treated cells (2,3,4) and that VCN admixed to a variety of antigens either structurally containing or lacking sialic acid, dose dependently acts as an adjuvant (5), predominantly for the cellular immune response (6).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Sedlacek, H.H., Seiler, F.R., Develop. biol. Standard 38 (1978) 399, Int. symp. on biolog. prepartions in the treatment of cancer, London, (1977) (S. Karger, Basel).
Sedlacek, H.H., Seiler, F.R., Behring Inst. Mitt. No. 55 (1974) 254.
Lüben, G., Sedlacek, H.H., Seiler, F.R., Behring Inst. Mitt. No. 59 (1976) 30.
Petitou, M., Rosenfeld, G., Sinay, P., Cancer Immunol. Immunotherapy 2 (1977) 135.
Knop, J., Sedlacek, H.H., Seiler, F.R., Immunology 34 (1978) 181.
Sedlacek, H.H., Seiler, F.R., Z. Immun. Forsch. 153,4 (1977) 353.
Seiler, F.R., Sedlacek, H.H.,(1978) Chessboard vaccination:A pertinent approach to immunotherapy of cancer with VCN and tumor cells? Proc. Symp. Immunotherapy of Malignant Diseases, Vienna, Nov. 1977, in press (Schattauer Verlag, Stuttgart).
Mackaness, G.B., Lagrange, P.H., Miller, T.E., Ishibashi, T., In: Activation of Macrophages, Ed. W.H. Wagner, H. Hahn, R. Evans, Excerpta Medica, Amsterdam, pp. 193–209 (1974).
Schick, H.J.,Zilg, H., Develop. biol. Standard. 38 (1978). Int. symp. on biological preparations in the treatment of cancer, London (1977) 81–85 (S. Karger, Basel).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Plenum Press, New York
About this chapter
Cite this chapter
Sedlacek, H.H., Bengelsdorff, H.J., Lemmer, A., Seiler, F.R. (1979). Approaches to Effective Tumor Immunotherapy with Cells and the Enzyme Neuraminidase. In: Müller-Ruchholtz, W., Müller-Hermelink, H.K. (eds) Function and Structure of the Immune System. Advances in Experimental Medicine and Biology, vol 114. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9101-6_129
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9101-6_129
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9103-0
Online ISBN: 978-1-4615-9101-6
eBook Packages: Springer Book Archive