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The Role of FSH, ICSH, and Endogenous Testosterone During Testicular Suppression by Exogenous Testosterone in Normal Men

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The Human Testis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 10))

Abstract

Testosterone administered to normal men is know to depress spermatogenesis to azoospermia, as reflected in the ejaculate, and to depress Leydig cell morphology to the point that only mesenchymal cells and fibroblasts are identifiable. It is also know that urinary total gonadotropins are concomitantly depressed to the point that they are undetectable in 24 hour urine aliquots administered to single assay rats (1). It has been widely assumed, but not proved, that the depression of human testicular function by administering testosterone is secondary to pituitary suppression.

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Author information

Authors and Affiliations

  1. Division of Reproductive Physiology, Pacific Northwest Research Foundation, 1102 Columbia Street, Seattle, Washington, 98104, USA

    Carl G. Heller, Howard C. Morse, Mike Su & Mavis J. Rowley

Authors
  1. Carl G. Heller
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  2. Howard C. Morse
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  3. Mike Su
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  4. Mavis J. Rowley
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Editor information

Editors and Affiliations

  1. Medical Research Institute of Worcester, Inc., Worcester City Hospital, Worcester, Massachusetts, USA

    Eugenia Rosemberg M. D. (Research Director) (Research Director)

  2. University of Washington School of Medicine, Seattle, Washington, USA

    C. Alvin Paulsen M. D. (Professor of Medicine) (Professor of Medicine)

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© 1970 Plenum Press, New York

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Heller, C.G., Morse, H.C., Su, M., Rowley, M.J. (1970). The Role of FSH, ICSH, and Endogenous Testosterone During Testicular Suppression by Exogenous Testosterone in Normal Men. In: Rosemberg, E., Paulsen, C.A. (eds) The Human Testis. Advances in Experimental Medicine and Biology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9008-8_19

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  • DOI: https://doi.org/10.1007/978-1-4615-9008-8_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9010-1

  • Online ISBN: 978-1-4615-9008-8

  • eBook Packages: Springer Book Archive

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