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Poly(ADP-Ribosyl)ation of Nuclear Proteins by Oxidant Tumor Promoters

  • Chapter
ADP-Ribose Transfer Reactions

Abstract

Oxidant tumor promoters. In the promotion phase of carcinogenesis, initiated cells which have undergone a genetic change as a consequence of the exposure to a carcinogen are allowed to expand preferentially at the cost of the surrounding tissue. The pathways which can lead to this result are expected to vary for different types of promoters and tissues. A major mechanism involves the differential modulation of the expression of growth-and differentiation- related genes in initiated and non-initiated epithelial cells and surrounding mesenchyme. Several scenarios are possible. For example in mouse skin promotion by the phorbolester promoter, TPA, a combination of general growth stimulation and preferential terminal differentiation of non-initiated cells may allow papilloma formation. Selective toxicity of a promoter to the tissue which surrounds initiated cells represents another important mechanism which facilitates the formation of a tumor nodule. Among the several classes of physiological and xenobiotic agents with promotional activity, oxidants are of particular interest (1–3). Because they are ubiquitous they may represent “natural” promoters. Traces of active oxygen (AO) are present in the air, while large amounts are released by stimulated inflammatory leukocytes and there are multiple metabolic reactions which produce AO intracellularly (1). Indeed in many instances tissue inflammation may be a necessary step in carcinogenesis (4–6).

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Author information

Authors and Affiliations

  1. Department of Carcinogenesis, Swiss Institute for Experimental Cancer Research, 1066, Epalinges, Switzerland

    P. Cerutti, G. Krupitza & D. Mühlematter

Authors
  1. P. Cerutti
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  2. G. Krupitza
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  3. D. Mühlematter
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Editors and Affiliations

  1. Department of Biochemistry, Texas College of Osteopathic Medicine, Fort Worth, Texas, 76107-2690, USA

    Myron K. Jacobson

  2. Department of Medicine, Texas College of Osteopathic Medicine, Fort Worth, Texas, 76107-2690, USA

    Elaine L. Jacobson

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© 1989 Springer-Verlag New York Inc.

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Cerutti, P., Krupitza, G., Mühlematter, D. (1989). Poly(ADP-Ribosyl)ation of Nuclear Proteins by Oxidant Tumor Promoters. In: Jacobson, M.K., Jacobson, E.L. (eds) ADP-Ribose Transfer Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-8507-7_42

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  • DOI: https://doi.org/10.1007/978-1-4615-8507-7_42

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-8509-1

  • Online ISBN: 978-1-4615-8507-7

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