Skip to main content

The Alcohol Dehydrogenase Polymorphism in Drosophila Melanogaster: Patterns of Variation for Three Alleles

  • Chapter
Advances in Genetics, Development, and Evolution of Drosophila

Abstract

Following the discovery of genetically determined electrophoretic variation at the alcohol dehydrogenase locus (Adh) in Drosophila melanogaster (Johnson and Dennison, 1964; Grell et al., 1965) evidence accumulated that the locus is polymorphic in many natural populations (O’Brien and MacIntyre, 1969; Berger, 1971; Vigue and Johnson, 1973; Band, 1975). The Adh locus in D. melanogaster, and the enzyme variants it encodes (Rasmuson et al., 1966; Gibson, 1970; Day et al., 1974), have been the subject of much research directed to understanding the mechanism of the maintenance of the polymorphism. Indeed the study of the Adh polymorphism has been chosen to illustrate the ways in which problems of enzyme polymorphisms in populations should be tackled if unambigous interpretations are to result from the experimental observations (Clarke, 1975).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anderson, D., 1982, Alcohol dehydrogenase activity and ethanol tolerance along the ADH cline in Australia, in: “Advances in Genetics, Development, and Evolution of Drosophila,” S. Lakovaara, ed., Plenum Press, New York.

    Google Scholar 

  • Anderson, P.R., 1981, Geographic clines and climatic associations of Adh and α-Gpdh gene frequencies in Drosophila melanogaster, in: “Genetic Studies of Drosophila Populations,” J.B. Gibson and J.G. Oakeshott, eds, Australian National University, Canberra.

    Google Scholar 

  • Band, H.T., 1975, A survey of isozyme polymorphism in a Drosophila melanogaster natural population, Genetics, 80:761.

    PubMed  CAS  Google Scholar 

  • Berger, E.M., 1971, A temporal survey of allelic variation in natural and laboratory populations of D. melanogaster, Genetics, 67:121.

    PubMed  CAS  Google Scholar 

  • Chambers, G.K., Wilks, A.V., and Gibson, J.B., 1981a, An electropho-retically cryptic alcohol dehydrogenase variant in Drosophila melanogaster. III. Biochemical properties and comparison with the common enzyme forms, Aust. J. Biol. Sci., (in press).

    Google Scholar 

  • Chambers, G.K., Laver, W.G., Campbell, S., and Gibson, J.B., 1981b, Structural analysis of an electrophoretically cryptic alcohol dehydrogenase variant from an Australian population of Drosophila melanogaster, Proc. Natl. Acad. Sci. (USA), 78:103.

    Article  Google Scholar 

  • Clarke, B., 1975, The contribution of ecological genetics to evolutionary theory: detecting the direct effects of natural selection on particular polymorphic loci, Genetics, 79:202.

    Google Scholar 

  • Day, T.H., Hillier, P.C., and Clarke, B., 1974, Properties of genetically polymorphic isozymes of alcohol dehydrogenase in Drosophila melanogaster, Biochem. Genet., 11:141.

    Article  PubMed  CAS  Google Scholar 

  • David, J., 1977, Signification d’un polymorphisme enzymatique: la deshydrogenase alcolique chez Drosophila melanogaster, Anne Biologique, 16:451.

    CAS  Google Scholar 

  • Fletcher, T.S., Ayala, F.J., Thatcher, D.R., and Chambers, G.K., 1978, Structural analysis of the ADHS electromorph of Drosophila melanogaster. Proc. Natl. Acad. Sci. (USA), 75:5609.

    Article  CAS  Google Scholar 

  • Gibson, J.B., 1970, Enzyme flexibility in Drosophila melanogaster, Nature, 227:959.

    Article  PubMed  CAS  Google Scholar 

  • Gibson, J.B., 1972, Differences in the number of molecules produced by two allelic electrophoretic enzyme variants in D. melanogaster, Experientia, 28:975.

    Article  PubMed  CAS  Google Scholar 

  • Gibson, J.B., Lewis, N., Adena, M.A., and Wilson, S.R., 1979. Selection for ethanol tolerance in two populations of Drosophila melanogaster segregating alcohol dehydrogenase allozymes, Aust. J. Biol. Sci., 32:387.

    PubMed  CAS  Google Scholar 

  • Gibson, J.B., Chambers, G.K., Wilks, A.V., and Oakeshott, J.G., 1980, An electrophoretically cryptic alcohol dehydrogenase variant in Drosophila melanogaster. I. Activity ratios, thermostability, genetic localisation and comparison with two other thermostable variants, Aust. J. Biol. Sci., 33:479.

    PubMed  CAS  Google Scholar 

  • Gibson, J.B., May, T.W., and Wilks, A.V., 1981a, Genetic variation at the alcohol dehydrogenase locus in Drosophila melanogaster in relation to environmental variation: Ethanol levels in breeding sites and allozyme frequencies, Oecologia (Berl.), (in press).

    Google Scholar 

  • Gibson, J.B., Wilks, A.V., and Chambers, G.K., 1981b, Population variation in functional properties of alcohol dehydrogenase in Drosophila melanogaster, in: “Genetic Studies of Drosophila Populations,” J.B. Gibson and J.G. Oakeshott, eds, Australian National University, Canberra.

    Google Scholar 

  • Grell, E.H., Jacobson, K.B., and Murphy, J.B., 1965, Alcohol dehydrogenase in Drosophila melanogaster: Isozymes and genetic variants, Science, 149:80.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, F.M. and Dennison, C., 1964, Genetic variation of alcohol dehydrogenase in Drosophila melanogaster, Nature, 204:906.

    Article  PubMed  CAS  Google Scholar 

  • Knibb, W.R., Oakeshott, J.G., and Gibson, J.B., 1981, Chromosome inversion polymorphism in Drosophila melanogaster, I. Latitudinal clines and associations between inversions in Australasian populations, Genetics, (in press).

    Google Scholar 

  • Kreitman, M., 1980, Assesments of variability within electromorphs of alcohol dehydrogenase in Drosophila melanogaster, Genetics, 95:467.

    PubMed  CAS  Google Scholar 

  • Lewis, N. and Gibson, J.B., 1978, Enzyme protein amount variation in natural populations, Biochem. Genet., 16:159.

    Article  PubMed  CAS  Google Scholar 

  • McKenzie, J.A. and McKechnie, S.W., 1978, Ethanol tolerance and the Adh polymorphism in a natural population of Drosophila melanogaster, Nature, 272:75.

    Article  PubMed  CAS  Google Scholar 

  • Oakeshott, J.G., Gibson, J.B., Anderson, P.R., and Champ, A., 1980, Opposing modes of selection on the alcohol dehydrogenase locus in Drosophila melanogaster, Aust. J. Biol. Sci., 33:105.

    CAS  Google Scholar 

  • Oakeshott, J.G. and Gibson, J.B., 1981, Is there selection by environmental ethanol on the alcohol dehydrogenase locus in Drosophila melanogaster? in: “Genetic Studies of Drosphila Populations,” J.B. Gibson and J.G. Oakeshott, eds, Australian National University, Canberra.

    Google Scholar 

  • Oakeshott, J.G., Gibson, J.B., Anderson, P.R., Knibb, W.R., Anderson, D.G., and Chambers, G.K., 1981, Alcohol dehydrogenase and glycerol-3-phosphate dehydrogenase clines in Drosophila melanogaster on three continets, Evolution, (in press).

    Google Scholar 

  • O’Brien, S.J. and Maclntyre, R.J., 1969, An analysis of gene-enzyme variability in natural populations of Drosophila melanogaster and D. simulans, Amer. Natur., 103:97.

    Article  Google Scholar 

  • Rasmuson, B., Nilson, L.R., Rasmuson, M., and Zeppezauer, E., 1966, Effects of heterozygosity on alcohol dehydrogenase (ADH) activity in Drosophila mealnogaster, Hereditas, 56: 313.

    Article  CAS  Google Scholar 

  • Sampsell, B., 1977, Isolation and genetic characterization of alcohol dehydrogenase thermostability variants occuring in natural populations of Drosophila melanogaster, Biochem. Genet., 15:971.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, M. and Jornvall, H., 1976, Structural analyses of mutants and wild-type alcohol dehydrogenases from Drosophila melanogaster, Eur. J. Biochem., 68:159.

    Article  PubMed  CAS  Google Scholar 

  • Thörig, G.E.W., Schoone, A.A., and Scharloo, W., 1975, Variation between electrophoretically identical alleles at the alcohol dehydrogenase locus in Drosophila melanogaster, Biochem. Genet., 13:721.

    Article  PubMed  Google Scholar 

  • Vigue, C.L. and Johnson, F.M., 1973, Isozyme variability in species of the genus Drosophila. VI. Frequency-property-environment relationships of allelic alcohol dehydrogenases in D. melanogaster, Biochem. Genet., 9:213.

    Article  PubMed  CAS  Google Scholar 

  • Wilks, A.V., Gibson, J.B., Oakeshott, J.G., and Chambers, G.K., 1980, An electrophoretically cryptic alcohol dehydrogenase variant in Drosophila melanogaster. II. Post-electrophoresis heat-treatment screening of natural populations, Aust. J. Biol. Sci., 33:575.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Gibson, J.B. (1982). The Alcohol Dehydrogenase Polymorphism in Drosophila Melanogaster: Patterns of Variation for Three Alleles. In: Lakovaara, S. (eds) Advances in Genetics, Development, and Evolution of Drosophila. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8321-9_23

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-8321-9_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8323-3

  • Online ISBN: 978-1-4615-8321-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics