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Expression and Substrate Specificities of Human Thymidine Kinase 1, Thymidine Kinase 2 and Deoxycytidine Kinase

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Purine and Pyrimidine Metabolism in Man VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 309B))

Abstract

Deoxynucleoside kinases catalyze 5′-phosphorylation of deoxynucleosides and deoxynucleoside analogs used in chemotherapy. Cytosolic thymidine kinase (TK1), mitochondrial thymidine kinase (TK2) and cytosolic deoxycytidine kinase (dCK) are key enzymes in this metabolism. They have been isolated from many sources and diverging results have been reported on their biochemical properties (reviwed in 1,2).

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Author information

Authors and Affiliations

  1. Department of Biochemistry I Karolinska Institute, Medical Nobel Institute, Stockholm, Sweden

    Staffan Eriksson, Birgitte Munch-Petersen, Borys Kierdaszuk & Elias Arnér

Authors
  1. Staffan Eriksson
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  2. Birgitte Munch-Petersen
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  3. Borys Kierdaszuk
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  4. Elias Arnér
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Editor information

Editors and Affiliations

  1. Institute of Child Health, London, UK

    R. Angus Harkness

  2. Burroughs Wellcome Co., Research Triangle Park, North Carolina, USA

    Gertrude B. Elion

  3. Universität München, München, Germany

    Nepomuk Zöllner

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© 1991 Plenum Press, New York

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Eriksson, S., Munch-Petersen, B., Kierdaszuk, B., Arnér, E. (1991). Expression and Substrate Specificities of Human Thymidine Kinase 1, Thymidine Kinase 2 and Deoxycytidine Kinase. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309B. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-7703-4_53

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  • DOI: https://doi.org/10.1007/978-1-4615-7703-4_53

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-7705-8

  • Online ISBN: 978-1-4615-7703-4

  • eBook Packages: Springer Book Archive

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