Skip to main content
SpringerLink
Log in

Cytosolic 5′-Nucleotidase/Phosphotransferase of Human Colon Carcinoma

  • Chapter
Purine and Pyrimidine Metabolism in Man VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 309B))

Abstract

Cytosolic 5′-nucleotidase acting preferentially on IMP and GMP has been purified from many sources1,2,3. The enzyme resulted to be allosterically activated by ATP, ADP and 2,3-diphosphoglycerate and inhibited by phosphate. Cytosolic 5′-nucleotidase appears to be widely distributed in mammalian tissues suggesting that it may have an essential function in cell metabolism. Furthermore the enzyme activity appears to be higher in tissues in active DNA synthesis or with a high turnover rate of nucleic acids and their precursors4.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Pinto, R.M., Canales, J., Faraldo, A., Sillerio, A., and Gunther Sillerio, M.A. (1987) Comp. Biochem. Physiol. 86B, 49–53.

    Google Scholar 

  2. Truong,Vu L., Collins, A. R., and Lowenstein, J.M. (1988) Biochem. J. 253, 117–121.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Bontemps, F., Van Den Berghe, G., and Hers, H.G. (1988) Biochem. J. 250, 687–696.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Itoh, R., and Yamada, K. (1991) Int. J. Biochem. 23, 461–465.

    Article  PubMed  CAS  Google Scholar 

  5. Worku, J., and Newby A.C. (1982) Biochem. J. 205, 503–510.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Keller, P.M., McKee, S.A., and Fyfe, J.A. (1985) J. Biol. Chem 260, 8664–8667.

    Google Scholar 

  7. Johnson, M.A., and Fridland, A. (1989) Mol. Pharmacol. 36, 291–295.

    PubMed  CAS  Google Scholar 

  8. Chen, P.S., Toribara, Jr.,T.,Y., and Warner, H. (1956) Anal. Chem. 28, 1756–1758.

    Article  CAS  Google Scholar 

  9. Camici, M., Tozzi, M.G., Allegrini, S., Del Corso, A., Sanfilippo, 0., Daidone, M.G., De Marco, C., and Ipata P.L. (1990) Cancer. Biochem. Biophys. 11, 201–209.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dipartimento di Fisiologia e Biochimica, Lab. di Biochimica, Via S. Maria, 55, 56100, Pisa, Italy

    M. G. Tozzi, M. Camici, S. Allegrini, R. Pesi, M. Turriani, A. Del Corso & P. L. Ipata

Authors
  1. M. G. Tozzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Camici
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Allegrini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Pesi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Turriani
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Del Corso
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. P. L. Ipata
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Child Health, London, UK

    R. Angus Harkness

  2. Burroughs Wellcome Co., Research Triangle Park, North Carolina, USA

    Gertrude B. Elion

  3. Universität München, München, Germany

    Nepomuk Zöllner

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Plenum Press, New York

About this chapter

Cite this chapter

Tozzi, M.G. et al. (1991). Cytosolic 5′-Nucleotidase/Phosphotransferase of Human Colon Carcinoma. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309B. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-7703-4_39

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-7703-4_39

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-7705-8

  • Online ISBN: 978-1-4615-7703-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation