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M Currents

  • Chapter
Ion Channels

Abstract

The M-current story began with some speculative and enjoyable experiments with Paul Adams in his laboratory at the Department of Physiology and Biophysics, UTMB, Galveston, Texas. We were trying to understand the voltage sensitivity of the apparent increase in membrane resistance, and the repetitive firing, produced by muscarine in sympathetic ganglia which Andy Constanti and I had noted in some tests on rat sympathetic neurons (Brown and Constanti, 1980). Kuba and Koketsu (1976) had previously noted a similar voltage sensitivity to the component of decreased conductance seen during the slow epsp in frog ganglia, but their explanation that acetylcholine inhibited the delayed rectifier seemed unlikely to us because muscarine did not prolong the action potential and its action differed radically from that of tetraethylammonium. Membrane currents induced by muscarine are small and require high-amplitude, low-noise voltage-clamp recording. Under these conditions we were immediately struck by the prominent time-dependent relaxations during voltage steps applied in the resting state and their disappearance in muscarine solution—the inverse of the situation seen with nicotinic agonists, where voltage-dependent current relaxations appear only during agonist application (Adams, 1975).

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  1. David A. Brown

    Present address: Department of Pharmacology, University College London, London, WC1E 6BT, England

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  1. MRC Neuropharmacology Research Group, Department of Pharmacology, School of Pharmacy, University of London, London , WC1N 1AX, England

    David A. Brown

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  1. Northwestern University Medical School, Chicago, Illinois, USA

    Toshio Narahashi

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Brown, D.A. (1988). M Currents. In: Narahashi, T. (eds) Ion Channels. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7302-9_2

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