Abstract
Characterization of hormonal regulation of prostatic cancer cell growth has been limited. Although a number of human prostate cancer cell lines have been described (1–3) and at least one spontaneously derived rat prostate cancer cell line has also been described (4), these cells were not useful for studies of hormonal regulation of prostate cancer because they were unresponsive to changes in hormonal milieu (1–4). Transplantable prostatic adenocarcinomas have been described in four breeds of rats (5–9). Androgen responsiveness has been established for certain of the Copenhagen and Nb rat tumors (8–10), is indicated for the AXC rat tumors (7), and apparently is absent in Lobund Wistar rat tumors (4,6). Initial biochemical characterization of the AXC and Copenhagen rat transplantable tumors has been reported (7,10,11).
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Shain, S.A., Boesel, R.W., Kalter, S.S., Heberling, R.L. (1982). AXC Rat Prostatic Adenocarcinoma: Characterization of Cells in Culture. In: Leavitt, W.W. (eds) Hormones and Cancer. Advances in Experimental Medicine and Biology, vol 138. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7192-6_20
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DOI: https://doi.org/10.1007/978-1-4615-7192-6_20
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