Abstract
Consciousness, being inwardly sensed and not accessible for objective study, has eluded a common interpretation among philosophers, biologists, and physicians. Each group tends to define the condition somewhat differently according to its own biases and interests. Some even have regarded consciousness as indefinable and its physical substrate beyond scientific analysis.
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References
Adametz, J. H., 1959, Rate of restitution and recovery of functioning in cats with rostral reticular lesions, J. Neurosurg. 16:85–97.
Adams, J. H., Graham, D. I., Murray, L. S., and Scott, G., 1982, Diffuse axonal injury due to non-missile head injury in humans: An analysis of 45 cases, Ann. Neurol. 12:557–563.
Adrian, E. D., 1941, Afferent discharges to the cerebral cortex from peripheral sense organs, J. Physiol. (London) 100:159–191.
Albert, M. L., Silverberg, R., Reches, A., and Berman, M., 1976, Cerebral dominance for consciousness, Arch. Neurol. 33:453–454.
Anderson, D. C., Bundlie, S., and Rockwold, G. L., 1984, Multimodality evoked potentials in closed head trauma, Arch. Neurol. 41:369–374.
Armstrong, D. M., Saper, C. B., Levey, A. I., Wainer, B. H., and Terry, R. D., 1983, Distribution of cholinergic neurons in rat brain: Demonstrated by the immunocytochemical localization of choline acetyltransferase, J. Comp. Neurol. 216:53–68.
Aserinsky, E., and Kleitman, N., 1953, Regularly occurring periods of eye motility and concomitant phenomena during sleep, Science 118:273–274.
Aston-Jones, G., and Bloom, F. E., 1981, Activity of norepinephrine-containing locus ceruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle, J. Neurosci. 1:876–886.
Austin, E. J., Wilkus, R. J., and Longstreth, W. T., 1988, Etiology and prognosis of alpha coma, Neurology 38:773–777.
Autret, A., Laffont, F., de Toffol, B., and Cathala, H. P., 1988, A syndrome of REM and non-REM sleep reduction and lateral gaze paresis after medial tegmental pontine stroke, Arch. Neurol. 45:1236–1242.
Bailey, P., 1955, Concerning the localization of consciousness, Trans. Am. Neurol. Assoc. 79:1–12.
Bard, P., and Macht, M. B., 1958, The behavior of chronically decerebrate cats, in: Neurologic Basis of Behavior (G. E. W. Wolstenholme and C. M. O’Connor, eds.), Churchill, London, pp. 55–75
Baron, J. C., D’Antonia, R., Pantano, P., Serdaru, M., Samson, Y., and Boussier, M. G., 1986, Effects of thalamic stroke on energy metabolism of the cerebral cortex, Brain 109: 1243–1259.
Batini, C., Moruzzi, G., Palestini, M., Rossi, G. F., and Zanchetti, A., 1959, Effects of complete pontine transections on the sleep-wakefulness rhythm: The midpontine pretrigeminal preparation, Arch. Ital. Biol. 97: 1–12.
Batsel, H. L., 1960, Electroencephalographic synchronization and desynchronization in the chronic cerveau of the dog, Electroencephalogr. Clin. Neurophysiol. 12: 421–430.
Baudrimont, M., Gray, F., Meinenger, V., Escourelle, R., and Castaigne, P., 1983, Atrophie cerebelleuse croisee apres lesion hemispherique survenue a l’age adulte, Rev. Neurol. 139: 485–495.
Berger, H., 1930, Uber das Elektroenkephalogramm des Menschen, J. Psychol. Neurol. 40: 160–179.
Bird, T. D., and Plum, F., 1968, Recovery from barbiturate overdose coma with a prolonged isoelectric electroencephalogram, Neurology 18: 456–460.
Bogousslavsky, J., Ferrazzini, M., Regli, F., Assal, G., Tanabe, H., and Delaloye-Bischof, A., 1988a, Manic delirium and frontal like syndrome with paramedian infarction of the right thalamus, J. Neurol. Neurosurg. Psychiatry 51: 116–119.
Bogousslavsky, J., Regli, F., and Uske, A., 1988b, Thalamic infarcts: Clinical syndromes, etiology and prognosis, Neurology 38: 837–848.
Bonvallet, M., and Allen, K. B., 1963, Prolonged spontaneous and evoked reticular activation following discrete bulbar lesions, Electroencephalogr. Clin. Neurophysiol. 15: 969–988.
Bonvallet, M., and Bloch, V., 1961, Bulbar control of cortical arousal, Science 133: 1133–1134.
Brain, R., 1958, The physiological basis of consciousness, Brain 81: 426–455.
Bremer, F., 1937, L’activitie cerebrale aucours du sommeil et de la narcose. Contribution a l’etude du mechanisme du sommeil, Bull. Acad. R. Med. Belg. 4: 68–86.
Bremer, F., 1938, Effets de la deafferentation complete d’une regionde l’encorce cerebrale sur son activite electrique spontanee, C.R. Soc. Biol. 127: 355–359.
Bremer, F., 1977, Cerebral hypnogogic centers, Ann. Neurol. 2: 1–6.
Brierley, J. B., Adams, J. H., Graham, D. I., and Walter, W. G., 1971, Neocortical death after cardiac arrest: A clinical neurophysiological and neuropathological report of two cases, Lancet 2: 560–565.
Briskin, J. G., Lehrman, K. L., and Guilleminault, C., 1978, Shy-Drager syndrome and sleep apnea, in: Sleep Apnea Syndrome (W. C.Dement and C.Guilleminault, eds.), Liss, New York, pp. 317–322
Broderson, P., and Jorgenson, E. O., 1974, Cerebral blood flow and oxygen uptake and cerebrospinal fluid biochemistry in severe coma, J. Neurol. Neurosurg. Psychiatry 37: 384–391.
Brown, J. R., and Baker, A. B., 1949, Poliomyelitis. I. Bulbar poliomyelitis: A neurophysiological interpretation of the clinicopathological findings, J. Nero. Ment. Dis. 109: 54–78.
Buchsbaum, M. S., Gillin, J. C., Wu, J., Hazlett, E., Sicotte, N., Dupont, R. M., and Bunney, W. E., 1989, Regional cerebral glucose metabolic rate in human sleep assessed by positron emission tomography, Life Sci. 45: 49–56.
Buzsaki, G., Bickford, R. G., Ponomareff, G., Thal, L. J., Mandel, R., and Gage, F., 1988, Nucleus basalis and thalamic control of neocortical activity in the freely moving rat, J. Neurosci. 8: 4007–4026.
Cairns, H., Oldfield, R. C., Pennybacker, J. B., and Whitteridge, D., 1941, Akinetic mutism with an epidermoid cyst of the third ventricle, Brain 64: 273–290.
Cant, B. R., Hume, A. L., Judson, J. A., and Shaw, N. A., 1986, The assessment of severe head injury by short-latency somatosensory and brainstem auditory evoked responses, Electroencephalogr. Clin. Neurophysiol. 65: 188–195.
Carpenter, M. B., and Sutin, J., 1983, Human Neuroanatomy 8th ed., Williams & Wilkins, Baltimore.
Castaigne, P., Buge, A., Cambier, J., Escourolle, R., Brunet, P., and Degos, J. D., 1966, Demence thalamique d’origine vasculaire par ramolissement bilateral, limite au territoire du pedicule retromamillaire, Rev. Neurol. 114: 89–107.
Castaigne, P., Lhermitte, F., Gautier, J. C., Escourolle, R., Derousne, C., Der Agopian, P., and Popa, C., 1973, Arterial occlusions in the vertebrobasilar system. A study of 44 patients with post mortem data, Brain 96: 133–154.
Castaigne, P., Lhermitte, F., Buge, A., Escourolle, R., Hauw, J. J., and Lyon-Caen, O., 1981, Paramedian thalamic and midbrain infarcts: Clinical and neuropathological study, Ann. Neurol. 10: 127–148.
Chagnac-Amitai, Y., and Connors, B. W., 1989, Horizontal spread of synchronized activity in neocortex and its control by GABA-mediated inhibition, J. Neurophysiol. 61: 747–758.
Chase, T. N., Moretti, L., and Prensky, A. L., 1968, Clinical and electroencephalographic manifestations of vascular lesions of the pons, Neurology, 18: 357–368.
Chatrian, G. E., 1975, Electrographic and behavioral signs of sleep in comatose states, in: Altered States of Consciousness, Coma, Cerebral Death (R.Harner and R.Naquet, eds.), Elsevier, Amsterdam, pp. 12–63
Chatrian, G. E., White, L. E., and Shaw, C.-M., 1964, EEG pattern resembling wakefulness in unresponsive decerebrate state following traumatic brain-stem infarct, Electroencephalogr. Clin. Neurophysiol. 16: 285–289.
Cicirate, F., Scrofani, A., and Biondi, R., 1987, Spindle and EEG sleep alterations in subjects affected by cortical cerebellar atrophy, Eur. Neurol. 26: 120–125.
Crick, F., 1984, Function of the thalamic reticular complex: The searchlight hypothesis, Proc. Natl. Acad. Sci. USA 81: 4586–4590.
Cummings, J. L., 1986, Subcortical dementia. Neuropsychology, neuropsychiatry, and pathophysiology, Br. J. Psychiatiy 149: 682–697.
De Armond, S. J., Fusco, M. M., and Dewey, M. M., 1976, Structure of the Human Brain: A Photographic Atlas2nd ed., Oxford University Press, London
Dell, P., 1973, Afferences baroceptives phases de synchronisation corticale et sommeil, Arch. Ital. Biol. 111: 553–563.
Deymeer, F., Smith, T. W., De Girolami, V., and Drachman, D. A., 1989, Thalamic dementia and motor neuron disease, Neurology 39: 58–61.
DiGirolami, O., Haas, M. L., and Richardson, E. P., 1974, Subacute diencephalic angioencephalopathy, J. Neurol. Sci. 22: 197–210.
Dougherty, J. H., Jr., Rawlinson, D. G., Levy, D. E., and Plum, F., 1981, Hypoxic-ischemic brain injury and the vegetative state. Clinical and neuropathological correlation, Neurology 31: 991–997.
Eisen, A., and Aminoff, M. J., 1986, Somatosensory evoked responses, in: Electrodiagnosis in Clinical Neurology (M. J. Aminoff, ed.), Churchill Livingstone, London, pp. 505–534
Engel, J., Jr., 1989, Seizures and Epilepsy Davis, Philadelphia, p. 344
Ericson, H., Watanabe, T., and Kohler, C., 1987, Morphological analysis of the tuberomammillary nucleus in the rat brain: Delineation of subgroups with antibody against L-histidine decarboxylase as a marker, J. Comp. Neurol. 263: 1–24.
Erwin, D. W., Somerville, E. R., and Radtke, R. A., 1984, A review of electroencephalographic features of normal sleep, J. Clin. Neurophysiol. 1: 253–274.
Facon, M., Steriade, M., and Wertheim, N., 1958, Hypersomnie prolonge engendere par des lesions bilaterales du systeme activateur medial. Le syndrome thrombotique de la bifurcation du tronc basilaire, Rev. Neurol. 98: 117–133.
Feeney, D. M., and Baron, J.-C., 1986, Diaschisis, Stroke 17: 817–830.
Feinberg, W. M., and Rapcsak, S. Z., 1989, “Peduncular hallucinosis” following paramedian thalamic infarction, Neurology 39: 1535–1537.
Foltz, E. L., and Schmidt, R. P., 1956, The role of the reticular function in the coma of head injury, J. Neurosurg. 13: 145–154.
Foote, S.L.Bloom, F. E., and Aston-Jones, G., 1983, Nucleus locus ceruleus: New evidence of anatomical and physiological specificity, Physiol. Rev. 63: 844–914.
Freeman, F. R., Salinas-Garcia, R. F., and Ward, J. W., 1973, Sleep patterns in a patient with a brain stem infarction involving the raphe nucleus, Electroencephalogr. Clin. Neurophysiol. 36: 657–660.
French, J. D., 1952, Brain lesions associated with prolonged unconsciousness, Arch. Neurol. Psychiatry 68: 727–740.
French, J. D., and Magoun, H. W., 1952, Effects of chronic lesions in central cephalic brainstem of monkeys, Arch. Neurol. 68: 591–604.
French, J. D., Von Amerongen, F. K., and Magoun, H. W., 1952, An activating system in brain stem of monkey, Arch. Neurol. Psychiatry 68: 577–590.
Fulton, J. F., and Bailey, P., 1929, Tumors in the region of the third ventricle: Their diagnosis and relation to pathological sleep, J. Nerv. Ment. Dis. 69: 1–25.
Fulton, J. F., and Bailey, P., 1929, Tumors in the region of the third ventricle: Their diagnosis and relation to pathological sleep, J. Nerv. Ment. Dis. 69: 145–164.
Fulton, J. F., and Bailey, P., 1929, Tumors in the region of the third ventricle: Their diagnosis and relation to pathological sleep, J. Nerv. Ment. Dis. 69: 261–277.
Ganes, T., and Lundar, T., 1983, The effect of thiopentone on somatosensory evoked responses and EEG’s in comatose patients, J. Neurol. Neurosurg. Psychiatry 46: 509–514.
Ganes, T., and Lundar, T., 1988, EEG and evoked potentials in comatose patients with severe brain damage, Electroencephalogr. Clin. Neurophysiol. 69: 6–13.
Gayet, M., 1875, Affection encephalique (encephalite diffuse probable), Arch. Physiol. 7: 341–3.
Gennarelli, T. A., Thibault, L. E., Adams, J. H., Graham, D. I., Thompson, C. J., and Marcinin, R. P., 1982, Diffuse axonal injury and traumatic coma in the primate, Ann. Neurol. 12: 564–574.
Gentilini, M., De Renzi, E., and Crisi, G., 1987, Bilateral parammedian thalamic artery infarcts: Report of eight cases, J. Neurol. Neurosurg. Psychiatry 50: 900–909.
Ginsberg, M. D., Myers, R. E., and McDonagh, B. F., 1974, Experimental carbon monoxide encephalopathy in the primate. II. Clinical aspects, neuropathology and physiological correlation, Arch. Neurol. 30: 209–215.
Girault, J.-A., Savaki, H. E., Desban, M., Glowinski, J., and Besson, M.-J., 1985, Bilateral cerebral metabolic alterations following lesion of the ventromedial thalamic nucleus: Mapping by the 14C-deoxyglucose method in conscious rats, J. Comp. Neurol. 231: 137–149.
Glenn, L. L., and Steriade, M., 1982, Discharge rate and excitability of cortically projecting intralaminar thalamic neurons during waking and sleep states, J. Neurosci. 2: 1387–1404.
Gloor, P., Kalabay, O., and Giard, N., 1968, The electroencephalogram in diffuse encephalopathies. Electroencephalographic correlates of gray and white matter lesions, Brain 91: 779–802.
Gloor, P., Ball, G., and Schaul, N., 1977, Brain lesions that produce delta waves in the EEG, Neurology 27: 326–333.
Graff-Radford, N. R., Damasio, H., Yamada, T., Eslinger, P. J., and Damasio, A. R., 1985, Nonhemorrhagic thalamic infarction-Clinical, neuropsychological and electrophysiological findings in four anatomical groups defined by computerized tomography, Brain 108: 485–516.
Guberman, A., and Stuss, D., 1983, The syndrome of bilateral paramedian thalamic infarction, Neurology 33: 540–546.
Hallanger, A. E., Levey, A. I., Lee, H. J., Rye, D. B., and Wainer, B. H., 1987, The origins of cholinergic and other subcortical afferents to the thalamus in the rat, J. Comp. Neurol. 262: 105–124.
Hankey, G. J., and Stewart-Wynne, E. G., 1988, Amnesia following thalamic hemorrhage. Another stroke syndrome, Stroke 19: 776–778.
Hassler, O., 1967, Arterial pattern of human brain stem. Normal appearance and deformation in expanding lesions, Neurology 17: 368–375.
Hayes, R. L., Pechura, C. M., Katayama, Y., Povlishock, J. T., Glebel, M. L., and Becker, D. P., 1984, Activation of pontine cholinergic sites implicated in unconsciousness following cerebral concussion in the cat, Science 233: 301–303.
Hayes, R. L., Stonnington, H. H., Lyeth, B. G., Dixon, C. E., and Yamamoto, T., 1986, Metabolic and neurophysiologic sequelae of brain injury: A cholinergic hypothesis, Cent. Nerv. Syst. Trauma 3: 163–173.
Heilman, K. M., and Valenstein, E. (eds.), 1985, Clinical Neuropsychology, 2nd ed., Oxford University Press, London
Heiss, W. O., Pawlick, G., Herholz, K., Wagner, R., and Weinhard, K., 1985, Regional cerebral glucose metabolism during wakefulness, sleep and dreaming, Brain Res. 327: 362–366.
Hertz, L., and Schousboe, A., 1975, Ion and energy metabolism of the brain at a cellular level, Int. Rev. Neurobiol. 18: 141–211.
Hobson, J. A., 1988, The Dreaming BrainBasic Books, New York
Hobson, J. A., and Steriade, M., 1986, The neuronal basis of behavioral state control, in: Handbook of Physiology, The Nervous System IV, Internal Regulatory Systems of the Brain (V. B.Mountcastle and F.Bloom, eds.), American Physiological Society, Bethesda, pp. 701–823
Hochman, M. S., Sowers, J. J., and Bruce-Gregorius, J., 1985, Syndrome of the mesencephalic artery: Report of a case with CT and autopsy findings, J. Neurol. Neurosurg. Psychiatry 48: 1179–1181.
Hoedt-Rasmussen, K., and Skinhoj, E., 1964, Transneural depression of the cerebral hemispheric metabolism in man, Acta Neurol. Scand. 40: 41–46.
Huh, K., Meador, K. J., Loring, D. W., Lee, G. P., and Brooks, B. S., 1989, Attentional mechanisms during the intracarotid amaobarbital test, Neurology 39: 1183–1186.
Ibuka, N., Inouye, S.-I., and Kawamura, H., 1977, Analysis of sleep-wakefulness in male rats after suprachiasmic lesions and ocular enucleation, Brain Res. 122: 33–47.
Ingvar, D. H., and Brun, A., 1972, Das komplette apallische syndrom, Arch. Psychiatr. Nervenkr. 215: 219–239.
Ingvar, D. H., and Sourander, P., 1970, Destruction of the reticular core of the brain stem. A pathoanatomic follow up of a case of coma of three years duration, Arch. Neurol. 23: 1–17.
Ingvar, D. H., Brun, A., Johansson, L., and Samuelsson, S. M., 1978, Survival after severe cerebral anoxia with destruction of the cerebral cortex: The apallic syndrome, Ann. N.Y. Acad. Sci. 315: 184–214.
Jasper, H. H., 1949, Diffuse projection systems: The integrative action of the thalamic reticular system, Electroencephalogr. Clin. Neurophysiol. 1: 405–420.
Jasper, H. H., 1958, Recent advances in our understanding of ascending activities of the reticular system, in: Reticular Formation of the Brain (H. H.Jasper, L. D.Proctor, R. K.Knighton, W. C.Noshay, and R. T.Costello, eds.), Little, Brown, Boston, pp. 319–331
Jefferson, G., 1958, The reticular formation and clinical neurology, in: Reticular Formation of the Brain (H. H.Jasper, L. D.Proctor, R. S.Knighton, W. C.Noshay, and R. T.Costello, eds.), Little, Brown, Boston, pp. 729–738
Jennett, B., and Plum, F., 1972, Persistent vegetative state after brain damage: A syndrome in search of a name, Lancet 1: 734–7.
Jones, B. E., and Cuello, A. C., 1989, Afferents to the basal forebrain cholinergic cell area from pontomesencephalic-catecholamine serotinin and acetylcholine-neurons, Neuroscience 31: 37–61.
Jones, B. E., Bobillier, P., Pin, C., and Jouvet, M., 1973, The effect of lesions of catecholaminecontaining neurons upon monoamine content of brain and EEG and behavioral waking in the cat, Brain Res. 58: 157–177.
Jones, E. A., Skolnick, P., Gammal, S. H., Basile, A. S., and Mullen, K. D., 1989, The gammaaminobutyric acid A (GABA A) receptor complex and hepatic encephalopathy, Ann. Intern. Med. 110: 532–546.
Jones, E. G., 1985, The ThalamusPlenum Press, New York
Jouvet, M., 1967, Neurophysiology of the states of sleep, Physiol. Rev. 47: 117–177.
Jouvet, M., 1972, The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle, Ergeb. Physiol. 64: 166–307.
Kaada, B. R., Harkmark, W., and Stokke, O., 1961, Deep coma associated with desynchronization in EEG, Electroencephalogr. Clin. Neurol. 13: 785–790.
Karnaze, D. S., Marshall, L. F., and Bickford, R. G., 1982, EEG monitoring of clinical coma: The compressed spectral array, Neurology 32: 289–292.
Katz, D. I., Alexander, M. P., and Mandell, A. M., 1987, Dementia following strokes in the mesencephalon and diencephalon, Arch. Neurol. 44: 1127–1133.
Kennedy, C., Gilin, J. C., Mendelson, W., Suda, S., Miyasaka, M., Ito, M., Nakamura, R. K., Storch, F. I., Pettigrew, K., Mishkin, M., and Sokoloff, L., 1982, Local cerebral glucose utilization in non rapid eye movement sleep, Nature 297: 325–327.
Kish, S. J., El-Awar, M., Schut, L., Leach, L., Oscar-Berman, M., and Freedman, M., 1988, Cognitive deficits in olivopontocerebellar atrophy: Implications for the cholinergic hypothesis of Alzheimer’s disease, Ann. Neurol. 24: 200–206.
Konigsmark, B. W., and Weiner, L. P., 1970, The olivopontocerebellar atrophies: A review, Medicine 49: 227–241.
Kritchevsky, M., Graff-Radford, N. R., , and Damasio, A. R., 1987, Normal memory after damage to medial thalamus, Arch. Neurol. 44: 959–962.
Krnjević, K., 1986, Neurotransmitters in cerebral cortex: A general account, Volume 2 (E. G.Jones and A.Peters, eds.), Plenum Press, New York, pp. 39–62
Krueger, J. M., and Karnovsky, M. L., 1986, Sleep and the immune response, Ann. N.Y. Acad. Sci. 496: 510–516.
Krueger, J. M., Karnovsky, M. L., and Pappenheimer, J. R., 1978, Sleep promoting factor S: Purification and properties, Proc. Natl. Acad. Sci. USA 75: 5235–5238.
Kubik, C. S., and Adams, R. D., 1947, Occlusion of the basilar artery—A clinical and pathological study, Brain 69: 73–96.
Kuhl, D. E., Phelps, M. E., Kowell, A. P., Metter, E. J., Selin, C., and Winter, J., 1980, Effects of stroke on local cerebral metabolism and perfusion: Mapping by emission computed tomograph of 18FDG and 13NH3, Ann. Neurol. 8: 47–60.
Lagreze, H. L., Levine, R. L., Pedula, K. L., Nickles, R. J., Sunderland, J. S., and Rowe, B. R., 1987, Contralateral flow reduction in unilateral stroke: Evidence for transhemispheric diaschisis, Stroke 18: 882–886.
Lamarca, M., and Fibiger, H. C., 1984, Deoxyglucose uptake and acetylcholine transferase activity in cerebral cortex following lesions of the nucleus basalis magnocellularis, Brain Res. 307: 366–369.
Lavie, P., Pratt, H., Scharf, B., Peled, R., and Brown, J., 1984, Localized pontine lesion: Nearly total absence of REM sleep, Neurology 34: 118–120.
Levey, A. I., Hallanger, A. E., and Wainer, B., 1987, Cholinergic nucleus basalis neurons may influence the cortex via the thalamus, Neurosci, Lett. 74: 7–13.
Levy, D. E., Knill-Jones, R. P., and Plum, F., 1978, The vegetative state and its prognosis following nontraumatic coma, Ann. N. Y. Acad. Sci. 315:293–306.
Levy, D. E., Sidtis, J. J., Rottenberg, D. A., Jarden, J. O., Strother, S. C., Dhawan, V., Ginos, J. Z., Tramo, M., Evans, A. C., and Plum, F., 1987, Differences in cerebral blood flow and glucose metabolism in vegetative versus locked-in patients, Ann. Neurol.22:673–682.
Lhermitte, F., Gauthier, J. C., Marteau, R., and Chain, F., 1963, Troubles de la conscience et mutism akinetique. Etude anatomo-clinique d’un ramolissement paramedian, bilateral, du pedoncule cerebral et du thalamus, Rev. Neurol. 109:115–131
Lin, J. S., Sakai, K., and Jouvet, M., 1988, Evidence for histaminergic arousal mechanisms in the hypothalamus of cats, Neuropharmacology 27: 111–122.
Lin, J. S., Sakai, K., Vanni-Mercer, G., and Jouvet, M., 1989, A critical role of the posterior hypothalamus in the mechanisms of wakefulness determined by microinjection of muscimol in freely moving cats, Brain Res. 479: 225–240.
Lindsley, D. B., Schreiner, L. H., Knowles, W. B., and Magoun, H. W., 1950, Behavioral and EEG changes following chronic brain stem lesions in the cat, Electroencephalogr. Clin. Neurophysiol. 2: 483–498.
Llinas, R. R., 1988, The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function, Science 242: 1654–1664.
Loeb, C., and Poggio, G., 1953, Electroencephalogram in a case with pontomesencephalic hemorrhage, Electroencephalogr. Clin. Neurophysiol. 5: 295–297.
Loeb, C., Rosadini, G., and Poggio, G., 1959, Electroencephalograms during coma. Normal and borderline records in five patients, Neurology 6: 610–618.
Longo, V. G., 1966, Behavioral and electroencephalographic effects of atropine and related compounds, Pharmacol. Rev. 18: 965–996.
Lugaresi, E., Medori, R., Montagna, P., Baruzzi, A., Cortelli, P., Lugaresi, A., Tinuper, P., Zucconi, M., and Gambetti, P., 1986, Fatal familial insomnia and dysautonomia with selective degeneration of thalamic nuclei, N. Engl. J. Med. 315: 997–1003.
Lundervold, A., Hauge, T., Loken, A. C., 1956, Unusual EEG in unconscious patient with brain stem atrophy, EEG Clin. Neurophysiol. 8: 665–670.
McGinty, D. J., and Sterman, M. B., 1968, Sleep suppression after basal forebrain lesion in the cat, Science 160: 1253–1255.
McGinty, D. J., Drucker-Colin, A., Morrison, A., and Parmeggiani, P. L. (eds.), 1985, Brain Mechanisms of SleepRaven Press, New York
McLellan, D. R., Adams, J. H., Graham, D. I., Kerr, A. E., Teasdale, G. M., 1986, The structural basis of the vegetative state and prolonged coma after nonmissile head injury. In, Papo, I., Cohadon, F., Massarotti, M. (eds.), Le Coma Traumatique. Padova, Liviana Editrice, pp. 165–185
Magni, F., Moruzzi, G., Rossi, G. F., and Zanchetti, A., 1959, EEG arousal following inactivation of the lower brain stem by selective injection of barbiturate into the vertebral circulation, Arch. Ital. Biol. 97: 33–46.
Markand, O. N., and Dyken, M. L., 1976, Sleep abnormalities in patients with brain stem lesions, Neurology 26: 769–776.
Martin, W. R., and Raichle, M. E., 1983, Cerebellar blood flow and metabolism in cerebral hemisphere infarction, Ann. Neurol. 14: 168–176.
Mauthner, L., 1890, Zur Pathologie und Physiologie des Schlafes nebst Bemerkungen ueber die “Nona,”, Wien. Klin. Wochenschr. 40: 961.
Mauthner, L., 1890, Zur Pathologie und Physiologie des Schlafes nebst Bemerkungen ueber die “Nona,”, Wien. Klin. Wochenschr. 40: 1001.
Mauthner, L., 1890, Zur Pathologie und Physiologie des Schlafes nebst Bemerkungen ueber die “Nona,”, Wien. Klin. Wochenschr. 40: 1049.
Mauthner, L., 1890, Zur Pathologie und Physiologie des Schlafes nebst Bemerkungen ueber die “Nona,”, Wien. Klin. Wochenschr. 40: 1092.
Mauthner, L., 1890, Zur Pathologie und Physiologie des Schlafes nebst Bemerkungen ueber die “Nona,”, Wien. Klin. Wochenschr. 40: 1144.
Mauthner, L., 1890, Zur Pathologie und Physiologie des Schlafes nebst Bemerkungen ueber die “Nona,”, Wien. Klin. Wochenschr. 40: 1185.
Mehler, M. F., 1989, The rostral basilar artery syndrome: Diagnosis, etiology, prognosis, Neurology 39: 9–16.
Meissner, I., Sapir, S., Kokmen, E., and Stein, S. D., 1987, The paramedian diencephalic syndrome: A dynamic phenomenon, Stroke 18: 380–385.
Mesulam, M. M. (ed.), 1985, Principles of Behavioral Neurology, Davis, Philadelphia
Mesulam, M. M., Waxman, S. G., Geschwind, N., and Sabin, T. D., 1976, Acute confusional states with right middle cerebral artery infarctions, J. Neurol. Neurosurg. Psychiatry 39: 84–89.
Mesulam, M. M., Mufson, E. J., Wainer, B. H., and Levey, A. I., 1983, Central cholinergic pathways in the rat: An overview based on an alternative nomenclature, Neuroscience 10: 1185–1201.
Mesulam, M. M., Geula, C., Bothwell, M. A., and Hersh, L. B., 1989, Human reticular formation: Cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons, J. Comp. Neurol. 281: 611–633.
Mills, R. P., and Swanson, P. D., 1978, Vertical oculomotor apraxia and memory loss, Ann. Neurol. 4: 149–151.
Moore, R. Y., 1978, Central neural control of circadian rhythms, in: Frontiers in Neuroendocrinology (W. F.Ganong and E.Martini, eds.), Raven Press, New York, pp. 185–206
Morison, R. S., and Bassett, D. L., 1945, Electrical activity of the thalamus and basal ganglia in decorticate cats, J. Neurophysiol. 8: 309–314.
Morison, R. S., and Dempsey, E. W., 1942, A study of thalamo-cortical relationships, Am. J. Physiol. 135: 281–292.
Morison, R. S., and Dempsey, E. W., 1942b, Mechanism of thalamocortical augmentation and repetition, Am. J. Physiol. 137: 297–308.
Morrison, J. H., Foote, S. L., and Bloom, F. E., 1984, Regional, laminar, developmental and functional characteristics of noradrenaline and serotonin innervation patterns in monkey cortex, in: Monoamine Innervation of Cerebral Cortex (L.Descarries, T. R.Reader, and H. H.Jasper, eds.), Liss, New York, pp. 61–75
Moruzzi, G., 1963, Active processes in the brain stem during sleep, Harvey Lect. 58: 233–297.
Moruzzi, G., 1964, Reticular influences on the EEG, Electroencephalogr. Clin. Neurophysiol. 16: 2–17.
Moruzzi, G., 1972, The sleep-waking cycle, Ergeb. Physiol. 64: 1–165.
Moruzzi, G., and Magoun, H. W., 1949, Brainstem reticular formation and activation of the EEG, Electroencephalogr. Clin. Neurophysiol. 1: 455–473.
Nakamura, R. K., Kennedy, C., Gillin, J. C., Suda, S., Ito, S., Storch, F. I., Mendelson, W., Sokoloff, L., and Mishkin, M., 1983, Hypnogenic center theory of sleep. No support from metabolic mapping in monkeys, Brain Res. 268: 372–376.
Nauta, W. J. H., 1946, Hypothalamic regulation of sleep in rats: Experimental study, J. Neurophysiol. 9s:285–316.
Neil, J. F., Holzer, B. C., Spiker, D. G., Coble, P. A., and Kupfer, D. J., 1980, EEG sleep alterations in olivopontocerebellar degeneration, Neurology 30: 660–662.
Niedermeyer, E., and Lopes da Silva, F. H., (eds.), 1987, Electroencephalography. Basic Principles, Clinical Applications and Related Fields, 2nd ed., Urban & Schwarzenberg, Munich
Obrador, S., Suarez-Reinoso, F., and Carbonelli, F., 1975, Comatose state maintained during eight years following a vascular ponto-mesencephalic lesion, Electroencephalogr. Clin. Neurophysiol. 38: 21–26.
Ohara, P. T., Chazal, G., and Ralston, H. J., 1989, Ultrastructural analysis of GABA-immunoreactive elements in the monkey thalamic ventrobasal complex, J. Comp. Neurol. 283: 541–558.
Orthner, H., 1969, Neuroanatomische Geisichtspunkte der Schlaf-Wach-Regeluug, in: Der Schlaf. Neurophysiologische (U. J.Jovanovic, ed.), Barth, Munich, pp. 49–84
Osorio, I., and Daroff, R. B., 1980, Absence of REM and altered NREM sleep in patients with spinocerebellar degeneration and slow saccades, Ann. Neurol. 7: 277–280.
Pantano, P., Baron, J. C., Samson, Y., Bousser, M. G., Derousne, C., and Comar, D., 1986, Crossed cerebellar diaschisis. Further studies, Brain 109: 677–694.
Peabody, J. L., Emery, J. R., and Ashwal, S., 1989, Experience with anencephalic infants as prospective organ donors, N. Engl. J. Med. 321: 344–350.
Penfield, W., 1938, The cerebral cortex in man. The cerebral cortex and consciousness, Arch. Neurol. Psychiatry 40: 417–442.
Percheron, G., 1973, The anatomy of the arterial supply of the human thalamus and its use for the interpretation of the thalamic vascular pathology, Z. Neurol. 205: 1–13.
Percheron, G., 1976, Les arteres du thalamus humain. Arteres et territoires thalamiques paramedians de l’artere basilaire communicante, Rev. Neurol. 132: 309–324.
Pierrot-Deseilliguy, C., Chain, F., Gray, F., Serdaru, M., Escourolle, R., and Lhermitte, F., 1982, Electro-oculographic and anatomical analyses of six vascular cases with deductions about vertical gaze organization in the premotor structures, Brain 105: 667–696.
Plum, F., and Posner, J. B., 1966, The Diagnosis of Stupor and Coma, 1st and 3rd eds., Davis, Philadelphia
Plum, F., and Posner, J. B., 1982, The Diagnosis of Stupor and Coma, 1st and 3rd eds., Davis, Philadelphia
Plum, F., and Swanson, A. G., 1958, Abnormalities in central regulation of respiration in acute and convalescent poliomyelitis, Arch. Neurol. Psychiatry 80: 267–285.
Plum, F., Posner, J. B., and Hain, R., 1962, Delayed neurological deterioration after anoxia, Arch. Intern. Med. 110: 56–63.
Purkinje, J. E., 1846, Wachen, Schlaf, Traum und verwandke Zustand, in: Handworterbuch der PhysiologieVolume 3 (R.Wagner, ed.), Braunschweig, Vieweg, pp. 412–480
Purpura, D. P., 1970, Operations and processes in thalamic and synaptically related subsystems, in: The Neurosciences—Second Study Program (F. O.Schmitt, ed.), Rockefeller University Press, New York, pp. 458–470
Quera Salva, M. A., and Guilleminault, C., 1986, Olivopontocerebellar degeneration, abnormal sleep and REM sleep without atonia, Neurology 36: 576–577.
Quinn, N. P., Rossor, M. N., and Marsden, C. D., 1986, Dementia and Parkinson’s disease—Pathological and neurochemical considerations, Br. Med. Bull. 42: 86–90.
Ranson, S. W., 1939, Somnolence caused by hypothalamic lesions in the monkey, Arch. Neurol. Psychiatry 41: 1–23.
Rechtschaffen, A., andKales, A. (eds.), 1968, A manual of standardized terminology, techniques, and scoring system for sleep stages in human subjects, Brain Information Service/Brain Research Institution, University of California, Los Angeles
Reiner, D. B., and McGeer, E. G., 1987, Electrophysiological properties of cortically projecting histamine neurons of the rat hypothalamus, Neurosci. Lett. 73: 43–47.
Relkin, N. R., Petito, C. K., and Plum, F., 1990, Coma and the vegetative state secondary to severe anoxic-ischemic damage involving the thalamus, Ann. Neurol. 28: 221–222.
Sakai, K., 1985, Anatomical and physiological basis of paradoxical sleep, in: Brain Mechanisms of Sleep (D. J.McGinty, R. D.Drucker-Colin, A.Morrison, and P. L.Parmeggiani, eds.), Raven Press, New York, pp. 111–137
Salamon, G., 1971, Atlas de la Vascularization Arterielle due Cerveau Chez L’homme, Sandoz Editions, Paris
Salazar, A. M., Grafman, J. H., Vance, S. C., Weingartner, H., Dillon, J. D., and Ludlow, C., 1986, Consciousness and amnesia after penetrating head injury: Neurology and anatomy, Neurology 36: 178–187.
Salazar-Grueso, E. F., Rosenberg, R. S., and Roos, R. P., 1988, Sleep apnea in olivopontocerebellar degeneration: Treatment with trazodone, Ann. Neurol. 23: 399–401.
Sallanon, M., Kitahama, K., Denoyer, M., Gay, N., and Jouvet, M., 1986, Insomnie de longue duree apres lesions des perikarions de l’aire preoptique paramediane chez le chat, C.R. Acad. Sci. 303: 403–409.
Sallanon, M., Aubert, C., Denoyer, M., Kitahama, K., and Jouvet, M., 1987, L’insomnie consecutive a la lesion de la region preoptique paramediane est reversible par inactivation de l’hypothalamus posterieur chez le chat, C.R. Acad. Sci. 305: 561–567.
Sallanon, M., Sakai, K., Buda, C., Puymartin, M., and Jouvet, M., 1988, Increase of paradoxical sleep induced by microinjections of ibotenic acid into the ventrolateral part of the posterior hypothalamus in the cat, Arch. Ital. Biol. 126: 87–97.
Saper, C. B., 1985, Organization of cerebral cortical afferent systems in the rat. II. Hypothalamo cortical projections, J. Comp. Neurol. 237: 21–46.
Saper, C. B., 1987, Diffuse cortical projection systems: Anatomical organization and role in cortical function, in: Handbook of Physiology I, The Nervous System V, Higher Functions of the Brain (V. B.Mountcastle and F.Plum, eds.), American Physiological Society, Bethesda, pp. 169–210
Savic, I., Persson, A., Rolanel, P., Pauli, S., Sedvall, G., and Widen, L., 1988, In-vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci, Lancet 2: 863–866.
Scheibel, A. B., 1984, The brain stem reticular core and sensory function, in: Handbook of Physiology I, The Nervous System III, Sensory Processes (J. B.Brookhart, V. B.Mountcastle, and I.Darien-Smith, eds.), American Physiological Society, Bethesda, pp. 213–256
Schofield, P. R., Darlison, M. G., Fujita, N., Burt, D. R., Stephenson, F. A., Rodriguez, H., Rhee, L. M., Ramachandran, J., Reale, V., Glencorse, T. A., Seeburg, T. H., and Barnard, E. A., 1987, Sequence and functional expression of the GABA receptor shows a ligand-gated super family, Nature 328: 221–227.
Schulman, S., 1957, Bilateral symmetrical degeneration of the thalamus: A clinico-pathological study, J. Neuropathol. Exp. Neurol. 16: 446–470.
Schuster, P., 1937, Beitrage zur pathologie du thalamus opticus—Part 4, Arch. Psychiatr. Nervenkr. 106: 201–233.
Schwartz, B., 1967, Hemispheric dominance and consciousness, Acta Neurol. Scand. 43: 513–525.
Segarra, J. M., 1970, Cerebral vascular disease and behavior. The syndrome of the mesencephalic artery (basilar artery bifurcation), Arch. Neurol. 22: 408–418.
Segarra, J. M., Von Stockert, T. R., and Curtis, M., 1974, Thalamic dementias, in: Neurology, Proc. X Int. Congr. Barcelona (A.Subirana and J. M.Espalader, eds.), Excerpta Medica, Amsterdam, pp. 392–395
Selkoe, D. J., 1989, Amyloid B protein precursor and the pathogenesis of Alzheimer’s disease, Cell 58: 611–612.
Serafetinides, E. A., Hoare, R. D., and Driver, M. V., 1965, Intracarotid sodium amylobarbitone and cerebral dominance for speech and consciousness, Brain 88: 107–130.
Siegel, J. M., Tomaszewski, K. S., and Nienhuis, R., 1986, Behavioral states in the chronic medullary and midpontine cat, Electroencephalogr. Clin. Neurophysiol. 63: 274–288.
Skinner, J. E., 1970, Electrocortical desynchronization during functional blockade of the mesencephalic reticular formation, Brain Res. 22: 254–258.
Smith, G. E., and Stern, K., 1938, Tumors of the thalamus, a clinicopathologic study, Brain 61: 339–374.
Speedie, L. J., and Heilman, K. M., 1983, Anterograde memory of deficits for visuospatial material after infarction of the right thalamus, Arch. Neurol. 40: 183–186.
Williams, J. B. W. (text editor), 1980, Diagnostic and Statistical Manual for Mental Disorders, 3rd ed. (DSM-III), American Psychiatric Association, Washington, D.C.
Sprague, J. M., 1967, The effects of chronic brain stem lesions on wakefulness, sleep and behavior, in: Sleep and Altered States of Consciousness (S. Kety, E. V. Evarts, and H. L. Williams, eds.), Res. Publ. Assoc. Res. Nerv. Ment. Dis.45:148–188.
Squire, L. R., and Moore, R. Y., 1979, Dorsal thalamic lesion in a noted case of human memory dysfunction, Ann. Neurol. 6: 503–506.
Squire, L. R., Amaral, D. G., Zola-Morgan, S., Kritchevsky, M., and Press, G., 1989, Description of brain injury in the amnesic patient NA based on magnetic resonance imaging, Exp. Neurol. 105: 23–35.
Steriade, M., and Deschennes, M., 1984, The thalamus as a neuronal oscillator, Brain Res. Rev. 8: 1–63.
Steriade, M., and Llinás, R. R., 1988, The functional states of the thalamus and the associated neuronal interplay, Physiol. Rev. 68: 649–742.
Sterman, M. B., and Clemente, C. D., 1962, Forebrain inhibitory mechanisms: Sleep patterns induced by basal forebrain stimulation in the behaving cat, Exp. Neurol. 6: 106–117.
Sterman, M. B., and Fairchild, M. D., 1966, Modifications of locomotor performance by reticular formation and basal forebrain stimulation in the cat: Evidence for reciprocal systems, Brain Res. 2: 205–217.
Stockard, J. J., Stockard, J. E., and Sharbrough, F. W., 1986, Brainstem auditory evoked potentials in neurology: Methodology, interpretation and clinical application, in: Electrodiagnosis in Clinical Neurology (M. J.Aminoff, ed.), Churchill/Livingstone, Edinburgh, pp. 505–534
Strich, S. J., 1956, Diffuse degeneration of the cerebral white matter in severe dementia following head injury, J. Neurol. Neurosurg. Psychiatry 19: 163–185.
Strich, S. J., 1961, Shearing of nerve fibers as a cause of brain damage due to head injury: A pathological study of twenty cases, Lancet 2: 443–448.
Szirmai, I., Guseo, A., and Molnar, M., 1977, Bilateral segmental softening of the thalamus, J. Neurol. 217: 57–65.
Szymusiak, R., and McGinty, D., 1986, Sleep-related neuronal discharge in the basal forebrain of cats, Brain Res. 370: 82–92.
Szymusiak, R., and McGinty, D., 1989, Effects of basal forebrain stimulation on the waking discharge of neurons in the midbrain reticular formation of cats, Brain Res. 498: 355–359.
Talairach, J., and Tournoux, P., 1988, Co-planar Stereotaxic Atlas of the Human Brain(translated by M. Rayport), Thieme, Stuttgart
Unnerstall, J. R., Wilcox, B. J., and Whitehouse, P. J., 1989, Biochemical and neuropathological aspects of Alzheimer’s disease, Curr. Opin. Neurol. Neurosurg. 2: 451–456.
Vanderwolf, C. H., and Stewart, D. J., 1988, Thalamic control of neocortical activation: A critical reevaluation, Brain Res. Bull. 204: 529–538.
Van Hoesen, G. W., and Damasio, A. R., 1987, Neural correlates in Alzheimer’s disease, in: Handbook of Physiology I, The Nervous System V, Higher Functions of the Brain (F.Plum and V. B.Mountcastle, eds.), American Physiological Society, Bethesda, pp. 871–898
Vanni-Mercier, G., Sakai, K., and Jouvet, M., 1984, Neurones specifiques de l’eviel dans l’hypothalamus du chat, C.R. Acad. Sci. 298: 195–200.
Victor, M., Adams, R. D., and Collins, G. H., 1989, The Wernicke-Korsakoff Syndrome and Related Neurological Disorders Due to Alcoholism and Malnutrition, 2nd ed., Davis, Philadelphia
Villablanca, J., 1962, Electroencephalogram in the permanently isolated forebrain of the cat, Science 138: 44–46.
Villablanca, J., 1966, Behavioral and polygraphic study of “sleep” and “wakefulness” in chronic decerebrate cats, Electroencephalogr. Clin. Neurophysiol. 21: 562–577.
Villablanca, J., 1974, Role of the thalamus in sleep control: Sleep-wakefulness studies in chronic diencephalic and athalamic cats, in: Basic Sleep Mechanisms (O.Petre-Quadeus and J. D.Schlag, eds.), Academic Press, New York, pp. 51–78
Von Cramon, D. Y., Hebel, N., and Shuri, V., 1985, A contribution to the anatomic basis of thalamic amnesia, Brain 108: 485–516.
von Economo, C., 1929, Schlaftheorie, Ergeb. Physiol. 28: 312–339.
von Economo, C., 1930, Sleep as a problem of localization, J. Nerv. Ment. Dis. 71: 249–259.
Wada, J., and Rasmussen, T., 1960, Intracarotid injection of sodium amytal for the lateralization of speech dominance, J. Neurosurg. 17: 266–282.
Wall, M., Slamovits, T. L., Weisberg, L. A., and Trufant, S. A., 1986, Vertical gaze ophthalmoplegia from infarction in the area of the posterior thalamo-subthalamic paramedian artery, Stroke 17: 546–555.
Walser, H., Matte, H., Keller, H. M., and Janzer, R., 1985, Early cortical median nerve somatosensory evoked potentials. Prognostic value in anoxic coma, Arch. Neurol. 42: 32–38.
Wang, R. Y., and Aghajanian, G. K., 1982, Correlative firing patterns of serotonergic neurons in rat dorsal raphe nucleus, J. Neurosci. 2: 11–16.
Watson, R. T., Valenstein, E., and Heilman, K. M., 1981, Thalamic neglect. Possible role of the medial thalamus and nucleus reticularis in behavior, Arch. Neurol. 38: 501–506.
Webster, H. H., and Jones, B. E., 1988, Neurotoxic lesions of the dorsolateral pontomesencephalic tegmentum-cholinergic cell area in the cat. II. Effects upon sleep-waking states, Brain Res. 458: 285–302.
Westmoreland, B. F., Klass, D. W., Sharbrough, F. W., and Reagan, T. J., 1975, Alpha-coma. Electroencephalographic, clinical, pathologic, and etiologic considerations, Arch. Neurol. 32: 713–718.
White, J. C., 1940, Autonomic discharge from stimulation of the hypothalamus, in: The Hypothalamus and Central Levels of Autonomic Function (J. F.Fulton, S. W.Ranson, and A. M.Frantz, eds.), Williams & Wilkins, Baltimore, pp. 854–863
Whitehouse, P. J., Price, D. L., Clark, A. W., Coyle, J. T., and DeLong, M. R., 1981, Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis, Ann. Neurol. 10: 122–126.
Wilkus, R. J., Harvey, F., Ojemann, L. M., and Lettich, E., 1971, Electroencephalogram and sensory evoked potentials. Findings in an unresponsive patient with pontine infarcts, Arch. Neurol. 24: 538–544.
Woods, J. W., 1964, Behavior of chronic decerebrate rats, J. Neurophysiol. 27: 635–644.
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Plum, F. (1991). Coma and Related Global Disturbances of the Human Conscious State. In: Peters, A., Jones, E.G. (eds) Normal and Altered States of Function. Cerebral Cortex, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6622-9_9
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