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The Hippocampal Formation of the Primate Brain

A Review of Some Comparative Aspects of Cytoarchitecture and Connections

  • Chapter
Cerebral Cortex

Part of the book series: Cerebral Cortex ((CECO,volume 6))

Abstract

The long-standing interest of neuroscientists in the hippocampal formation has occurred from the perspective of two rather different points of view. On the one hand, the comparatively simple cytoarchitecture of the hippocampal formation and the laminar segregation of its extrinsic and intrinsic afferents make it an interesting and relatively simple model system for experimental manipulation and investigation. Chapter 8 in this volume, by Schwartzkroin and Mueller, is a thoughtful review of how effective the hippocampus has been as a model system for neurophysiological studies using the in vitro slice preparation. Other investigations have utilized the hippocampal formation to study the effects of genetic defects in neuronal development (e.g., Nowakowski and Davis, 1985), collateral sprouting induced by deafferentation (e.g., Lynch et al. 1972; Cotman and Nadler, 1978), or intracerebral transplantation (e.g., Frotscher and Zimmer, 1986). While most of the studies that use the hippocampal formation as a model system have focused on the rodent, the other major interest in the hippocampal formation has grown out of a variety of clinical and experimental data derived from humans and nonhuman primates. These latter investigations have focused on the disruption of certain aspects of the memory process produced by hippocampal lesions as first described in human neurosurgical patients (Scoville and Milner, 1957; Penfield and Milner, 1958) and subsequently investigated in nonhuman primates (e.g., Moss et al. 1981).

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Authors and Affiliations

  1. Department of Anatomy, Boston University School of Medicine, 02118, Boston, Massachusetts, USA

    Douglas L. Rosene

  2. Departments of Anatomy and Neurology, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA

    Gary W. Van Hoesen

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  1. Douglas L. Rosene
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  2. Gary W. Van Hoesen
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  1. California College of Medicine, University of California, Irvine, Irvine, California, USA

    Edward G. Jones

  2. Boston University College of Medicine, Boston, Massachusetts, USA

    Alan Peters

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© 1987 Plenum Press, New York

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Rosene, D.L., Van Hoesen, G.W. (1987). The Hippocampal Formation of the Primate Brain. In: Jones, E.G., Peters, A. (eds) Cerebral Cortex. Cerebral Cortex, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6616-8_9

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  • DOI: https://doi.org/10.1007/978-1-4615-6616-8_9

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