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Pilus Adhesins

  • Chapter
Bacterial Adhesion

Abstract

The adhesion of bacteria to mucosal surfaces has been the focus of study in several laboratories around the world during the past decade and the results have led to a better understanding of the interactions between animal hosts and microbes. The study of bacterial adhesion to animal cells has been stimulated, in part, by the recognition of the importance of these processes in the pathogenesis of diseases caused by bacteria. As such, most of the ensuing discussion will be based on the data obtained from studies of disease pathogenesis. In particular, I shall use as primary examples, results from studies on the pathogenesis of enterotoxigenic Escherichia coli diarrheal disease and E. coli-induced urinary tract infections as these provide the most extensively studied examples of bacterial adhesion to animal cells. The initiation of most bacterial infections of mucosal surfaces requires the bacterial species in question to colonize and maintain a stable population at the mucosal site. In the cases of pathogenic E. coli, colonization is facilitated by adhesion to the mucosa, the adhesion being mediated by bacterial structures called pili. The following discussion will describe in detail the molecular basis of pilus-mediated bacterial adhesion to mucosal surfaces (animal cells). Although the structure and function of pili will be emphasized, the recognition and specificity of receptors on the animal cells is critical and will also be described (see Chapter 4, Section 4).

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  1. Richard E. Isaacson

    Present address: Pfizer Central Research, Groton, Connecticut, 06340, USA

Authors and Affiliations

  1. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, 48109, USA

    Richard E. Isaacson

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  1. University of Illinois, Urbana, Illinois, USA

    Dwayne C. Savage

  2. University of Warwick, Coventry, England

    Madilyn Fletcher

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© 1985 Plenum Press, New York

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Isaacson, R.E. (1985). Pilus Adhesins. In: Savage, D.C., Fletcher, M. (eds) Bacterial Adhesion. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6514-7_11

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  • DOI: https://doi.org/10.1007/978-1-4615-6514-7_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6516-1

  • Online ISBN: 978-1-4615-6514-7

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