Abstract
Metabolism of bile acids plays a key role in the etiology of two of the most common causes of death, coronary heart disease and colon cancer. Bile acids are the major route of excretion of steroid from the body and thus a determinant of changes in sterol balance, a risk factor for coronary heart disease. Risk for colon cancer has been shown to increase with increased concentrations of bile acids in the colon, both in epidemiological studies in humans and in experimental animal studies. Dietary fiber plays a major role in regulating the metabolism of bile acids and altering risk for these diseases. However we know little of the specific mechanisms involved in the role played by dietary fiber in bile acid metabolism.
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© 1997 Springer Science+Business Media New York
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Story, J.A., Furumoto, E.J., Buhman, K.K. (1997). Dietary Fiber and Bile Acid Metabolism — An Update. In: Kritchevsky, D., Bonfield, C. (eds) Dietary Fiber in Health and Disease. Advances in Experimental Medicine and Biology, vol 427. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5967-2_27
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DOI: https://doi.org/10.1007/978-1-4615-5967-2_27
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