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Coordinate Regulation of Cholesterol 7α-Hydroxylase and HMG-CoA Reductase in the Liver

  • Chapter
Cholesterol

Part of the book series: Subcellular Biochemistry ((SCBI,volume 28))

Abstract

Cholesterol homeostasis in the liver is dependent upon the activity of a number of key structures: 3-hydroxy-3-methylglutaryl-CoA, HMG-CoA reductase (HMGR), acyl cholesterol acyltransferase, cholesterol 7α-hydroxylase, and the LDL receptor (for a review, see Goldstein and Brown, 1990). The regulation of all these proteins is steroid dependent. This steroid-dependent regulation has been characterized in some detail at the gene level for HMG CoA synthase and the LDL receptor, and involves sophisticated coordinate transcriptional control, with interaction of trans-acting factors with sterol regulatory elements (SRE-1) sequences present in the promoter regions of these genes. In addition to this transcriptional control, there may also be regulatory control at different posttranscriptional levels. The detailed mechanism behind the sterol-dependent regulation of the other key enzymes is not as well characterized at present.

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Authors and Affiliations

  1. Department of Clinical Chemistry, Huddinge University Hospital, Karolinska Institute, S-141 86, Huddinge, Sweden

    Ingemar Björkhem, Erik Lund & Mats Rudling

  2. Department of Medicine, Huddinge University Hospital, Karolinska Institute, S-141 86, Huddinge, Sweden

    Ingemar Björkhem, Erik Lund & Mats Rudling

  3. Center for Nutrition and Toxicology, Huddinge University Hospital, Karolinska Institute, S-141 86, Huddinge, Sweden

    Ingemar Björkhem, Erik Lund & Mats Rudling

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  1. Ingemar Björkhem
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  2. Erik Lund
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  1. Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, New York, 11367-1597, USA

    Robert Bittman

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Björkhem, I., Lund, E., Rudling, M. (1997). Coordinate Regulation of Cholesterol 7α-Hydroxylase and HMG-CoA Reductase in the Liver. In: Bittman, R. (eds) Cholesterol. Subcellular Biochemistry, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5901-6_2

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