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Neurogenic Inflammation

A Model for Studying Efferent Actions of Sensory Nerves

  • Chapter
Frontiers in Arterial Chemoreception

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 410))

Abstract

Cytoplasmic vesicles, resembling synaptic vesicles of efferent nerve fibers,* are a distinctive feature of sensory nerve fibers that innervate glomus cells of the carotid body (Biscoe et al, 1970; Kobayashi & Uehara, 1970; McDonald & Mitchell, 1975). Ultrastructural studies have shown that some vesicles cluster at synaptic junctions where sensory nerves are presynaptic to glomus cells (McDonald & Mitchell, 1975; Verna, 1979; Pallot, 1987). This finding has led to speculation that substances from sensory nerves influence glomus cells (McDonald & Mitchell, 1975). Indeed, the phenomenon of “efferent inhibition” (Neil & O’Regan, 1969, 1971), in which electrical stimulation of the carotid sinus nerve inhibits chemoreceptor firing, has been interpreted as an efferent action of sensory nerves on glomus cells (McDonald & Mitchell, 1981). Although there are other interpretations of the mechanism underlying efferent inhibition (Biscoe, 1971; Sampson et al, 1976; O’Regan, 1977, 1981; Acker & O’Regan, 1981), the morphological evidence that sensory nerves are presynaptic to glomus cells is compelling.

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Author information

Authors and Affiliations

  1. Cardiovascular Research Institute, University of California, San Francisco, California, 94143, USA

    Donald M. McDonald, Jeffrey J. Bowden & Peter Baluk

  2. Department of Anatomy, University of California, San Francisco, California, 94143, USA

    Donald M. McDonald, Jeffrey J. Bowden & Peter Baluk

  3. Department of Physiology, University of California, San Francisco, California, 94143, USA

    Nigel W. Bunnett

  4. Department of Surgery, University of California, San Francisco, California, 94143, USA

    Nigel W. Bunnett

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  1. Donald M. McDonald
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  2. Jeffrey J. Bowden
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  3. Peter Baluk
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  4. Nigel W. Bunnett
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Editor information

Editors and Affiliations

  1. Catholic University of Chile, Santiago, Chile

    Patricio Zapata

  2. University of Utah School of Medicine, Salt Lake City, Utah, USA

    Carlos Eyzaguirre

  3. University of Oxford, Oxford, England

    Robert W. Torrance

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© 1996 Springer Science+Business Media New York

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McDonald, D.M., Bowden, J.J., Baluk, P., Bunnett, N.W. (1996). Neurogenic Inflammation. In: Zapata, P., Eyzaguirre, C., Torrance, R.W. (eds) Frontiers in Arterial Chemoreception. Advances in Experimental Medicine and Biology, vol 410. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5891-0_70

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  • DOI: https://doi.org/10.1007/978-1-4615-5891-0_70

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