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Skin Ageing

The Relevance of Antioxidants

  • Chapter
Molecular Gerontology

Abstract

Ageing can be defined as the time-related impairment of organ functionality or as a general decline in organic functions as well as a decrease in adaptiveness to change, and to restore disrupted homeostasis1. This definition, though satisfactory for the layman interested and, we dare say, preoccupied by his own ageing, is non satisfactory, at least to the biochemist, in so far as it does not allow to make quantitative measurements which can be easily generalised to individuals of other species. On the other hand, such a possibility is allowed, for instance, by a more reductionistic definition, which can be gathered by considering that ageing is the time-related accumulation of molecular modifications in an organ or in an organism2. Such modifications can be mutations or deletions in DNA, carbonylation of proteins in the extra cellular matrix and so on.

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Authors and Affiliations

  1. R.A.D. L’Oréal, Chevilly-Larue, France

    Paolo U. Giacomoni

  2. C.H. U. Necker, Paris, France

    Patrizia D’Alessio

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  1. Paolo U. Giacomoni
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  2. Patrizia D’Alessio
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  1. University of Aarhus, Aarhus, Denmark

    Suresh I. S. Rattan

  2. The University of Namur, Namur, Belgium

    Olivier Toussaint

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Giacomoni, P.U., D’Alessio, P. (1996). Skin Ageing. In: Rattan, S.I.S., Toussaint, O. (eds) Molecular Gerontology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5889-7_11

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  • DOI: https://doi.org/10.1007/978-1-4615-5889-7_11

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