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DNA replication licensing factor

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

DNA Replication Licensing Factor (RLF) is an essential activity required to restrict the duplication of genomic DNA to precisely once per cell cycle. Recent fractionation of RLF activity from Xenopus egg extracts has resulted in the identification of two essential components, RLF-B and RLF-M. RLF-M has been purified to homogeneity and has been shown to consist of a complex of proteins in the MCM/P1 family. RLF-B is still unidentified, but possible candidates for this activity have been identified in yeast. Elucidation of the RLF mechanism will provide important insights into the way that chromosome replication is controlled.

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References

  1. Blow, J.J. and Laskey, R.A. (1988) Nature 332, 546–548.

    Article  PubMed  CAS  Google Scholar 

  2. Blow, J.J. and Laskey, R.A. (1986) Cell. 47, 577–587.

    Article  PubMed  CAS  Google Scholar 

  3. Blow, J.J. and Watson, J.V. (1987) EMBO J. 6, 1997–2002.

    PubMed  CAS  Google Scholar 

  4. Lohka, M.J. and Masui, Y. (1983) Science 220, 719–721.

    Article  PubMed  CAS  Google Scholar 

  5. Newmeyer, D.D., Lucocq, J.M., Burglin, T.R. and De Robertis, E.M. (1986) EMBO J. 5, 501–510.

    PubMed  CAS  Google Scholar 

  6. Newport, J. (1987) Cell 48, 205–217.

    Article  PubMed  CAS  Google Scholar 

  7. Sheehan, M.A., Mills, A.D., Sleeman, A.M., Laskey, R.A. and Blow, J.J. (1988) J. Cell. Biol. 106, 1–12.

    Article  PubMed  CAS  Google Scholar 

  8. Blow, J.J., Sheehan, M.A., Watson, J.V. and Laskey, R.A. (1989) J. Cell. Sci. Suppl. 12, 183–195.

    PubMed  CAS  Google Scholar 

  9. Blow, J.J. and Sleeman, A.M. (1990) J. Cell. Sci 95, 383–391.

    PubMed  CAS  Google Scholar 

  10. Blow, J.J., Dilworth, S.M., Dingwall, C., Mills, A.D. and Laskey, R.A. (1987) Philos. Trans. R. Soc. Lond. B. Biol. Sci. 317, 483–494.

    Article  PubMed  CAS  Google Scholar 

  11. De Roeper, A., Smith, J.A., Watt, R.A. and Barry, J.M. (1977) Nature 265, 469–470.

    Article  PubMed  Google Scholar 

  12. Leno, G.H., Downes, C.S. and Laskey, R.A. (1992) Cell. 69, 151–158.

    Article  PubMed  CAS  Google Scholar 

  13. Coverley, D., Downes, C.S., Romanowski, P. and Laskey, R.A. (1993) J. Cell. Biol. 122, 985–992.

    Article  PubMed  CAS  Google Scholar 

  14. Blow, J.J. (1993) J Cell. Biol. 122, 993–1002.

    Article  PubMed  CAS  Google Scholar 

  15. Kubota, Y. and Takisawa, H. (1993) J. Cell. Biol. 123, 1321–1331.

    Article  PubMed  CAS  Google Scholar 

  16. Chong, J.P., Mahbubani, H.M., Khoo, C.Y. and Blow, J.J. (1995) Nature 375, 418–421.

    Article  PubMed  CAS  Google Scholar 

  17. Kubota, Y., Mimura, S., Nishimoto, S., Takisawa, H. and Nojima, H. (1995) Cell 81, 601–609.

    Article  PubMed  CAS  Google Scholar 

  18. Madine, M.A., Khoo, C.Y., Mills, A.D. and Laskey, R.A. (1995) Nature 375, 421–424.

    Article  PubMed  CAS  Google Scholar 

  19. Madine, M.A., Khoo, C.-Y., Mills, A.D., Musahl, C. and Laskey, R.A. (1995) Curr. Biol. 5, 1270–1279.

    Article  PubMed  CAS  Google Scholar 

  20. Maine, G.T., Sinha, P. and Tye, B.K. (1984) Genetics 106, 365–385.

    PubMed  CAS  Google Scholar 

  21. Sinha, P., Chang, V. and Tye, B.-K. (1986) J. Mol Biol. 192, 805–814.

    Article  PubMed  CAS  Google Scholar 

  22. Gibson, S.I., Surosky, R.T. and Tye, B.K. (1990) Mol. Cell. Biol. 10, 5707–5720.

    PubMed  CAS  Google Scholar 

  23. Ray, A., Roy, N., Maitra, M. and Sinha, P. (1994) Curr. Genet. 26, 403–409.

    Article  PubMed  CAS  Google Scholar 

  24. Chen, Y., Hennessy, K.M., Botstein, D. and Tye, B.K. (1992) Proc. Natl. Acad. Sci. USA 89, 10459–10463.

    Article  PubMed  CAS  Google Scholar 

  25. Moir, D., Stewart, S.E., Osmond, B.C. and Botstein, D. (1982) Genetics 100, 547–563.

    PubMed  CAS  Google Scholar 

  26. Hennessy, K.M., Lee, A., Chen, E. and Botstein, D. (1991) Genes Dev. 5, 958–969.

    Article  PubMed  CAS  Google Scholar 

  27. Yan, H., Gibson, S. and Tye, B.K. (1991) Genes Dev. 5, 944–957.

    Article  PubMed  CAS  Google Scholar 

  28. Yan, H., Merchant, A.M. and Tye, B.K. (1993) Genes Dev. 7, 2149–2160.

    Article  PubMed  CAS  Google Scholar 

  29. Hennessy, K.M., Clark, C.D. and Botstein, D. (1990) Genes Dev. 4, 2252–2263.

    Article  PubMed  CAS  Google Scholar 

  30. Dalton, S. and Whitbread, L. (1995) Proc. Natl. Acad. Sci. USA 92, 2514–2518.

    Article  PubMed  CAS  Google Scholar 

  31. Kimura, H., Nozaki, N. and Sugimoto, K. (1994) EMBO J. 13, 4311–4320.

    PubMed  CAS  Google Scholar 

  32. Forsburg, S.L. and Nurse, P. (1994) J. Cell. Sci. 107, 2779–2788.

    PubMed  CAS  Google Scholar 

  33. Coxon, A., Maundrell, K. and Kearsey, S.E. (1992) Nucl. Acids Res. 20, 5571–5577.

    Article  PubMed  CAS  Google Scholar 

  34. Takahashi, K., Yamada, H. and Yanagida, M. (1994) Mol. Biol.Cell. 5, 1145–1158.

    PubMed  CAS  Google Scholar 

  35. Sykes, D.E. and Weiser, M.M. (1995) Gene 163, 243–247.

    Article  PubMed  CAS  Google Scholar 

  36. Su, T.T., Feger, G. and O’Farrell, P.H. (1996) Mol. Biol. Cell. 7, 319–329.

    PubMed  CAS  Google Scholar 

  37. Springer, P.S., McCombie, W.R., Sundaresan, V. and Martienssen, R.A. (1995) Science 268, 877–880.

    Article  PubMed  CAS  Google Scholar 

  38. Bucci, S., Ragghianti, M., Nardi, I., Bellini, M., Mancino, G. and Lacroix, J.C (1993) Int. J. Dev. Biol. 37, 509–517.

    PubMed  CAS  Google Scholar 

  39. Thömmes, P., Fett, R., Schray, B., Burkhart, R., Barnes, M., Kennedy, C., Brown, N.C. and Knippers, R. (1992) Nucl. Acids Res. 20, 1069–1074.

    Article  PubMed  Google Scholar 

  40. Koonin, E.V. (1993) Nucl. Acids Res. 21, 2541–2547.

    Article  PubMed  CAS  Google Scholar 

  41. Chong, J.P.J., Thömmes, P. and Blow, J.J. (1996) Trends Biochem. Sci. 21, 102–107.

    PubMed  CAS  Google Scholar 

  42. Kearsey, S.E., Maiorano, D., Holmes, E.C. and Todorov, I.T. (1996) Bioessays 18, 183–190.

    Article  PubMed  CAS  Google Scholar 

  43. Burkhart, R., Schulte, D., Hu, D., Musahl, C., Gohring, F. and Knippers, R. (1995) Eur. J. Biochem. 228, 431–438.

    Article  PubMed  CAS  Google Scholar 

  44. Kimura, H., Takizawa, N., Nozaki, N. and Sugimoto, K. (1995) Nucl. Acids Res. 23, 2097–2104.

    Article  PubMed  CAS  Google Scholar 

  45. Starborg, M., Brundell, E., Gell, K., Larsson, C., White, I., Daneholt, B. and Hoog, C. (1995) J. Cell. Sci. 108, 927–934.

    PubMed  CAS  Google Scholar 

  46. Schulte, D., Burkhart, R., Musahl, C., Hu, B., Schlatterer, C., Hameister, H. and Knippers, R. (1995) J. Cell. Sci. 108, 1381–1389.

    PubMed  CAS  Google Scholar 

  47. Todorov, I.T., Pepperkok, R., Philipova, R.N., Kearsey, S.E., Ansorge, W. and Werner, D. (1994) J. Cell. Sci. 107, 253–265.

    PubMed  CAS  Google Scholar 

  48. Todorov, L.T., Attaran, A. and Kearsey, S.E. (1995) J. Cell. Biol. 129, 1433–1445.

    Article  PubMed  CAS  Google Scholar 

  49. Fujita, M., Kiyono, T., Hayashi, Y. and Ishibashi, M. (1996) J. Biol. Chem.271, 4349–4354.

    Google Scholar 

  50. Fujita, M., Kiyono, T., Hayashi, Y. and Ishibashi, M. (1996) Biochem. Biophys. Res. Comm. 219, 604–607.

    Article  PubMed  CAS  Google Scholar 

  51. Coué, M., Kearsey, S.E. and Méchali, M. (1996) EMBO J. 15, 1085–1097.

    PubMed  Google Scholar 

  52. Hartwell, L.H. (1976) J. Mol. Biol. 104, 803–817

    Article  PubMed  CAS  Google Scholar 

  53. Lisziewicz, J., Godany, A., Agoston, D.V. and Kuntzel, H. (1988) Nucl Acids Res. 16, 11507–11520.

    Article  PubMed  CAS  Google Scholar 

  54. Zhou, G, Huang, S.H. and Jong, A.Y. (1989) J. Biol. Chem. 264, 9022–9029.

    PubMed  CAS  Google Scholar 

  55. Zwerschke, W., Rottjakob, H.W. and Kuntzel, H. (1994) J. Biol. Chem. 269, 23351–23356.

    PubMed  CAS  Google Scholar 

  56. Zhou, C. and Jong, A. (1990) J. Biol. Chem. 265, 19904–19909.

    PubMed  CAS  Google Scholar 

  57. Bueno, A. and Russell, P. (1992) EMBO J. 11, 2167–2176.

    PubMed  CAS  Google Scholar 

  58. Jallepalli, P.V. and Kelly, T.J. (1996) Genes Dev. 10, 541–552.

    Article  PubMed  CAS  Google Scholar 

  59. Hogan, E. and Koshland, D. (1992) Proc. Natl. Acad. Sci. USA 89, 3098–3102.

    Article  PubMed  CAS  Google Scholar 

  60. Piatti, S., Lengauer, C. and Nasmyth, K. (1995) EMBO J. 14, 3788–3799.

    PubMed  CAS  Google Scholar 

  61. Cocker, J.H., Piatti, S., Santocanale, C., Nasmyth, K. and Diffley, J.F.X. (1996) Nature 379, 180–182.

    Article  PubMed  CAS  Google Scholar 

  62. Liang, C., Weinreich, M. and Stillman, B. (1995) Cell. 81, 667–676.

    Article  PubMed  CAS  Google Scholar 

  63. Bell, S.P. and Stillman, B. (1992) Nature 357, 128–134.

    Article  PubMed  CAS  Google Scholar 

  64. Gavin, K.A., Hidaka, M. and Stillman, B. (1995) Science 270, 1667–1671.

    Article  PubMed  CAS  Google Scholar 

  65. Gossen, M., Pak, D.T.S., Hansen, S.K., Acharya, J.K. and Botchan, M.R. (1995) Science 270, 1674–1677.

    Article  PubMed  CAS  Google Scholar 

  66. Carpenter, P.B., Mueller, P.R. and Dunphy, W.G. (1996) Nature 379, 357–360.

    Article  PubMed  CAS  Google Scholar 

  67. Diffley, J.F.X. and Cocker, J.H. (1992) Nature 357, 169–172.

    Article  PubMed  CAS  Google Scholar 

  68. Diffley, J.F., Cocker, J.H., Dowell, S.J. and Rowley, A. (1994) Cell. 78, 303–316.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. DNA Replication Control Laboratory, ICRF Clare Hall Laboratories, South Mimms, Herts., EN6 3LD, UK

    James P. J. Chong & J. Julian Blow

Authors
  1. James P. J. Chong
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  2. J. Julian Blow
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Editor information

Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer , Silvana Guidet  & Lee Vogel ,  & 

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Chong, J.P.J., Blow, J.J. (1996). DNA replication licensing factor. In: Meijer, L., Guidet, S., Vogel, L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5873-6_8

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  • DOI: https://doi.org/10.1007/978-1-4615-5873-6_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7693-4

  • Online ISBN: 978-1-4615-5873-6

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