Abstract
The existence of circadian oscillations in the level of hormones, in numerous physiological parameters, in toxicity and in behavior is now fully recognized in all living organisms. In contrast, the synchronisation and regulation of cell proliferation by circadian rhythms in vivo is only starting to be appreciated. This article reviews the experimental evidence for circadian synchronisation of cell division in different mammalian tissues (mainly the gastro-intestinal tract and hemapoietic system), including tumoral tissues. The possible causes of this coupling of the cell cycle phases to the circadian rhythm are discussed. Testing of novel antitumour agents using murine models should take into consideration the temporal difference between murine and human circadian control of proliferation (the peak of DNA synthesis occurs during the activity period, i.e. during daytime in man, and at night-time in mice and rats). Experimental and clinical data clearly support the important implications of the circadian control of the cell cycle in the optimisation of cancer chemotherapy, both for reducing toxicity and increasing the antitumour effects.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Edmunds, Jr. L.N. and Laval-Martin, D.L. (1982) in Cell cycle clocks (Edmunds Jr., L. N. ed.), pp. 295–324, New York, Marcel Dekker.
Touitou, Y. and Haus, E. (1992) Biologic rhythms in clinical and laboratory medicine Berlin, Springer-Verlag.
Smaaland, R. and Sothern, R.B. (1994) in Circadian cancer therapy (Hrushesky, W.J.M. ed.) Boca Raton, CRC Press.
Hastings, M. (1995) Nature 376, 296–297
Cross. F., Roberts, J. and Weintraub, H. (1989) Annu Rev Cell. Biol. 5, 341–395.
Murray, A.W. and Kirschner. M.W. (1989) Science 246, 614–621.
Lewin, B. (1990) Cell. 61, 743–752.
King, R.W. Jackson, P.K. and Kirschner, M.W. (1993) Cell. 79, 563–571.
Sherr, C.J. (1994) Cell. 79, 551–555.
Coleman, T.R. and Dumphy, W.G. (1994) Curr. Opin. Cell. Biol. 6, 877–882.
Sherr, C.J. and Roberts, J.M. (1995) Genes Dev. 9, 1149–1163.
Peters, G. (1994) Nature 371, 204–205.
Polyak, K., Lee, M.H., Erdjument-Bromage, H., Tempst, P. and Massague, J. (1994) Cell. 78, 59–66.
Kato, J., Matsuoka, M., Polyak, K., Massague, J. and Sherr, C.J. (1994) Cell. 79, 487–496.
Hengst, L. and Reed, S.I. (1996) Science 271, 1861–1864.
Wood, P.A. and Hrushesky, W.J.M. (1994) in Circadian cancer therapy (Hrushesky, W. J. M. ed.) Boca Raton, CRC Press.
Young, M.R.I., Matthewa, J.P., Kanabrocki, E.L., Sothern, R.B., Roitman-Johnson, B. and Scheving, L.E. (1995) Int. J. Chronobiol. 12, 19–27.
Sothern, R.B., Roitman-Johnson, B., Kanabrocki, E.L., Yager, J.G., Roodell, M.M., Weatherbee, J.A., Young, M.R.I., Nemchausky, B.M. and Scheving, L.E. (1995) J. Allergy Clin. Immunol 95, 1029–1035.
Perpoint, B., Le Bousse-Kerdiles, C., Clay, D., Smadja-Joffe, F., Depres-Brummer, P., Laporte-Simitsidis, S., Jasmin, C. and Lévi, F. (1995) Exp. Hematol. 23, 362–368.
Cos, S. and Sanches-Barcelo, E.J. (1994) Cancer lett. 85, 105–109.
Creanor, J. and Mitchison, J.M. (1986) J. Cell. Sci. 86, 207–215.
Novak, B. and Mitchison, J.M. (1986) J. Cell. Sci. 86, 191–206.
Whitfield. J.F., Durkin, J.P., Franks, D.J., Kleine, L.P., Raptis, L., Rixon, R.H., Sikorska, M. and Walker, P.R. (1987) Cancer Metast. Rev. 5, 205–250.
Dumont, J.E., Jauniaux, J.C. and Roger, P.P. (1989) Trends Biochem. Sci. 14, 67–71.
Boynton, A.L. and Whitfield, J.F. (1983) Adv. Cyclic Nucleotide Res. 15, 193–294.
Matsumoto, K., Uno, I. and Ishiakawa, T. (1985) Yeast 1, 15–24.
Carell, E.F. and Deardfield, K.L. (1982) Life Sci. 31, 249–254.
Carré, I.A., Laval-Martin, D.L. and Edmunds, Jr. L.N. (1989) J. Cell. Sci. 94, 267–272.
Edmunds, Jr. L.N., Carré, I.A., Tamponnet, C. and Tong, J. (1992) Chronobiol. Int. 9, 180–200.
Carré, I.A. and Edmunds, Jr. L.N. (1990) Cyclic AMP, cell division cycles, and circadian oscillators in Euglena. Bethesda, MD. ASCB/EMBO Conference on’ The Cell. Cycle”.
Edmunds, Jr. L.N. and Carré, I.A. (1990) Cyclic AMP, cell division cycles, and circadian oscillators in Euglena, 37. 2nd. meeting of the Society for Research on Biological Rhythms. Amelia Island, Jacksonville, FL.
Draetta, G., Luca, F., Westendorf, J., Brizuela, L., Ruderman, J. and Beach, D. (1989) Cell. 56, 829–838.
Edmunds, Jr. L. (1993) Signal transduction between circadian clock and cell division cycle. I-4, 21st. Conference of the International Society for Chronobiology. Quebec City.
Fortuyn-Van Leyden, C.E.D. (1917) Proc. kon. nederl. Akad. Wet. (c) 19, 38–44.
Pilgrim, C., Erb, W. and Maurer, W. (1963) Nature 199, 863–865.
Halberg, F., Halberg, E., Barnum, C.P. and Bittner, J.J. (1959) in Photoperiodism and Related Phenomena in Plants and Animals (Withrow, R. B. ed.) pp. 803–878, Ed. Publ. No 55 of the Amer. Assoc. Adv. Sci. Washington D.C.
Thorud, E., Clausen, O.P.F. and Laerum, O.D. (1984) in Cell. cycle clocks (Edmunds, L. N. j. ed.) pp. 113–133, New York, Basel, Marcel Dekker, Inc.
Cooper, Z.K. and Schiff, A. (1938) Proc. Soc. exp. Biol. (N.Y.) 39, 323–324.
Bullough, W.S. (1948) Proc. roy. Soc. Lond. (Biol.) 135, 212–232.
Scheving, L.E. (1959) Anat. Rec. 135, 7–19.
Evensen, A. (1963) Bull. WHO 28, 513–515.
Rubin, N. and Scheving, L.E. (1983) J. invest. Dermatol. 80, 79–80.
Frentz, G., Moller, U., Holmich, P. and Christensen, I.J. (1991) Acta Derm. Venereol. 71, 85–87.
Tvermyr, E.M.F. (1972) Virch Arch (Cell. Pathol) 11, 43–54.
Clausen, O.P.F., Thorud, E. and Kaufman, S.L. (1982) Int. J. Chronobiol 8, 83–93.
Møller, U. and Keiding, N. (1982) Cell. Tiss. Kinet. 15, 341–350.
Møller, U., Keiding, N. and Engel, F. (1982) Cell. Tiss. Kinet. 15, 157–168.
Brown, W.R. (1991) J. Invest, dermatol 97, 273–280.
Halberg, F., Barnum, C.P., Silber, R.H. and Bittner, J.J. (1958) Proc. Soc. Exp. Biol. (N.Y.) 97, 897–900.
Souto, M. and Echavellanos, J.M. (1985) Chronobiol. Int. 2, 169–175.
Scheving, L.E. and Pauly, J.E. (1973) Int. J. Chronobiol. 1, 269–286.
Scheving, L.E., Pauly, J.E., Von Mayersbach, H. and Dunn, J.D. (1974) Acta Pathol 88, 411–423.
Refsum, S.B., Haskjold, E., Bjerknes, R. and Iversen, O.H. (1991) Virchows Arch. B. Cell. Pathol Incl Mol Pathol. 60, 225–230.
Benestad, H.B. and Laerum, O.D. (1989) in Current Topics In Pathology (Iversen, O.H. ed.) 79, 7–36, Berlin, Springer-Verlag.
Canon, C., Lévi, F., Reinberg, A. and Mathé, G. (1985) Leukemia Res. 9, 1539–1546.
Lévi, F., Canon, C., Blum, J.P., Mechkouri, M., Reinberg, A. and Mathé, G. (1985) J. Immunol 134, 217–222.
Bartlett, P., Haus, E., Tuason, T., Sackett-Lundeen, L. and Lakatua, D. (1982)in Proc. 15th international Conference on Chronobiology (Haus, E. and Kabat, H. F. eds) Basel, Karger, S.
Laerum, O.D. and Aardal, N.P. (1985) in Clinical Aspects of Chronobiology (Rietveld, W. J. eds.) pp. 85–97, Leiden, Meducation Service Hoechst.
Lévi, F., Blazcek, I. and Ferlé-Vidovic, A. (1988) Exp. Hematol 16, 696–701.
Laerum, O.D; and Paukovits, W.R. (1984) Exp. Hematol. 12, 7–17.
Sletvold, O., Laerum, O.D. and Riise, T. (1988) Eur. J. Haematol. 40, 42–49.
Sletvold, O., Laerum, O.D. and Riise, T. (1988) Mech. Aging Dev. 42, 91–104.
Klein, C.S. and Geisel, H. (1947) Klin. Wochenschr. 25, 662-.
Raitsina, S.S. (1961) Bull. Exp. Biol. Med. 51, 494–497.
Gololobova, M.T. (1958) Bull Exp. Biol. Med. 40, 1143-.
Loisner, L.D., Artemiva, N.S. and Babaeva, A.G. (1962) Bull Exp. Biol. Med. 54, 77-.
Sinha, H.P. (1960) Patna. J. Med. 34, 301-.
Clark, R.H. and Baker, B.L. (1963) Am. J. Physiol. 204, 1018–1022.
Sigdestad, CT., Bauman, J. and Lesher, S. (1969) Exp. Cell. Res. 538, 159–162.
Sigdestad, C.T. and Lesher, S. (1970) Experientia (Experimenta) 26, 1321–1322.
Leblond, C.P. and Stevens, CE. (1948) Anat. Rec. 100, 357–377.
Bertalanfy, F.D. (1960) Acta Anat. 40, 130-.
Hunt, T.E. (1952) Anat. Rec. (Abstr.) 112, 346.
von Muhlemann, H.R., Marthaler, T.M. and Rateitschak, K.H. (1956) Acta Anat. 28, 331.
Scheving, L.E., Burns, E.R. and Pauly, J.E. (1972) Am. J. Anat. 135, 311–317.
Appleton, D.R., Sunter, J.P. and Watson, A.J. (1981) Cell. proliferartion in the gastrointestinal tract.London, Pitman Medical Ltd.
Scheving, L.E., Tsai, T.H. and Scheving, L.A. (1983) Amer. J. Anat. 168, 433–465.
Kennedy, M.F.G., Tutton, P.J.M. and Barkla, D.H. (1985) Cancer Letters 28, 169–175.
Kaur, P. and Porten, C.S. (1986) Cell. Tiss. Kinet. 19, 591–599.
Scheving, L.E., Feuers, R.J., Tsai, T.H. and Scheving, L.A. (1994) in Circadian cancer therapy (Hrushesky, W.J.M. ed.) pp. 19–40, Boca Raton.
Scheving, L.E., Burns, E.R., Pauli, J.E. and Tsai, T.H. (1978) Anat. Rec. 191, 479–486.
Scheving, L.E., Tsai, T.H. and Scheving, L.A. (1983) Am. J. Anat. 168, 433–465.
Thorud, E., Clausen, O.P.F. and Bjerknes, R. (1978) in Pulse Cytometry (Lutz, D. ed.) 3, 359, Ghent, European Press.
Møller, U. and Larsen, J.K. (1978) Cell. Tissue Kinet. 12, 405–413.
Clausen, O.P.F., Thorud, E., Bjerknes, R. and Elgjo, K. (1979) Cell. Tissue Kinet. 12, 319–337.
Laerum, O.D. and Aardal, N.P. (1981) in 11th International Congress of Anatomy, part C., Biol.ogical rhythms in structure and function (von Mayersbach, H., Scheving, L.E.and Pauli, J.E. eds.) pp. 87–97, New York, Alan R. Liss.
Rubin, N.H. (1981) in Biological Rhythms in Structure and Function (von Mayersbach, H., Scheving, L.E. and Pauly, J.E. eds.) pp. 82, New York, Alan R. Liss.
Rubin, N.H. (1982) Radiat. Res. 89, 65–76.
Rubin, N.H., Hokanson, J.A. and Mayshak, J.W. (1983) Am. J. Anat. 168, 15–26.
Scheving, L.E., Scheving, L.A., Tsai, T.H. and Pauly, J.E. (1984) J. Nutr. 114, 2160–2166.
Quastler, H. and Sherman, F.G. (1959) Exp. Cell. Res. 17, 420-.
Burns, E.R. and Scheving, L.E. (1975) Cell. Tissue Kinet. 8, 61–66.
Burns, E.R., Scheving, L.E., Fawcett, D.F., Gibbs, W.M. and Galatzan, R.E. (1976) Anat. Rec. 184, 265–273.
Scheving, L.E., Tsai, T.H., Scheving, L.A., Feuers, R.J. and Kanabrocki, E.L. (1992) in Biol.ogic Rhythms in Clinical and Laboratory Medicine (Touitou, Y. and Haus, E. eds.) 566, Berlin, Springer-Verlag.
Warnakulasuriya, K.A. and MacDonald, D.G. (1993) Arch. Oral Biol. 12, 1107–1111.
Warnakulasuriya, K.A. and MacDonald, D.G. (1995) Arch. Oral Biol. 40, 107–110.
Khan, S., Raza, A., Petrelli, N. and Mittleman, A. (1988) J. Surg. Oncol. 39, 114–118.
Buchi, K.N., Moore, J.G., Hrushesky, W.J.M., Sothern, R.B. and Rubin, N.H. (1991) Gastroenterology 101, 410–415.
Potten, C.S., Chwalinski, S., Swindell, R. and Palmer, M. (1982) Cell. Tiss. Kinet. 15, 351–370.
Marra, G., Anti, M., Percesepe, A., Armelao, F., Ficarelli, R., Coco, C., Rinelli, A., Vecchio, F.M. and D’Arcangelo, E. (1994) Gastroenterology 106, 982–987.
Beck, L., Reick, D.V. and Damann, B. (1959) Proc. Soc. Exp. Biol. Med. 97, 229–231.
Lohrman, H-P. and Schreml, W. (1982) in Cytotoxic drugs and the granulopoietic system 81, 155–182, Berlin, Heidelberg, New York., Springer-Verlag.
Gordon, M.Y., Barrett, A.J. and Gordon-Smith, E.C. (1985) Bone marrow disorders. The biological basis of clinical problems pp. 1–422, Oxford, Blackwell Scientific.
Arendt, J., Minors, D.S. and Waterhouse, J.M. (1989) in Biological rhythms in clinical practice.(Arendt, J., Minors, D. S. and Waterhouse, J. M. eds.) pp. 3–7, London, Boston, Singapore, Sydney, Toronto, Wellington, Wright.
Butcher, E.C (1990) Am. J. Pathol. 136, 3–11.
Laerum, O.D. (1995) Exp. Hematol. 23, 1145–1147.
Fisher, L.B. (1968) Br. J. Dermatol. 60, 75.
Spivak, J.L. (1984) in The principles and Practice of Medicine (Harvey, A. M., Johns, R. J., McKusick, V. A., Owens, A. H. and Ross, R. S. eds.) 21st ed., 465, Norwalk, Appleton-Century-Crofts.
Nathan, D.G. (1987) in Oxford Textbook of Medicine (Weatherall, D.J., Ledingham, J.G.G. and Warrell, D.A. eds) 2nd. ed. 2, Oxford University Press.
Laerum, O.D. and Paukovits, W.R. (1989) Pharmac. Ther. 44, 335–349.
Gordon, M.Y., Barrett, A.J. and Gordon-Smith, E.C. (1985) Bone marrow disorders. The biological basis of clinical problems 1–422, Oxford, Blackwell Scientific.
Pizzarello, D.J. and Witcofski, R.L. (1970) Radiology 97, 165–167.
Burns, E.R. (1981) Cancer Res. 41, 2795–2802.
Sharkis, S.J., LoBue, J., Alexander, P.J., Rakowitz, F., Weitz-Hamburger, A. and Gordon, A.S. (1971) Proc. Soc. Exp. Biol. Med. 138, 494–496.
Sharkis, S.J., Palmer, J.D., Goodenough, J., LoBue, J. and Gordon, A.S. (1974) Cell. Tiss. Kinet. 7, 381–387.
Moskalik, K.G. (1976) Bull Exp. Biol. Med. (USSR) 81, 594.
Dörmer, P., Schmolke, W., Muschalik, P. and Brinkman, W. (1970) Beitr. Pathol. 141, 174–186.
Stoney, P.J., Halberg, F. and Simpson, H. W. (1975) Chronobiologia 2, 319–323.
Aardal, N.P., Laerum, O.D. and Paukovits, W.R. (1982) Virch. Arch. B Cell. Pathol. 38, 253–261.
Aardal, N.P. (1984) Exp. Hematol. 12, 61–67.
Aardal, N.P. and Laerum, O.D. (1983) Exp. Hematol. 11, 792–801.
Smaaland, R. and Sothern, R.B. (1994) in Circadian Cancer Therapy (Hrushesky, W.J.M. ed.) pp. 119–163, Boca Raton, CRC Press.
Klevecz, R.R., Shymko, R.M., Blumenfeld, D. and Braly, P.S. (1987) Cancer Res. 47, 6267–6271.
Hromas, R.A., Hutchins, J.T., Marke, D.E. and Scholes, V.E. (1981) Chronobiologica 8, 369–373.
Clark, R.H. and Korst, D.R. (1969) Science 166, 236–237.
Scheving, L.E. and Pauly, J.E. (1973) Int. J. Chronobiol. 1, 269–286.
Hunt, N.H. and Perris, A.D. (1974) J. Endocrinol. 62, 451–462.
Haus, E., Lakatua, D.J., Swoyer, J. and Sackett-Lundeen, L. (1983) Am. J. Anat. 168, 467–517.
Scheving, L.A., Tsai, T.H. and Scheving, L.E. (1986) Chronobiol. Intl. 3, 1–15.
Vacek, A. and Rotkovska, D. (1970) Strahlentherapie 140, 302–306.
Simmons, DJ., Loeffelman, K., Frier, C., McCoy, R., Friedman, B., Melville, S. and Kahn, A.J. (1984) in Chronobiology (Haus, E. and Kabat, H. eds.) pp. 37–42, Basel, S.Karger.
Halder, C., Häussier, D. and Gupta, D. (1992) J. Pineal Res. 12, 79–83.
Goldeck, H. (1948) Ärztl Forsch 2, 22–27.
Goldeck, H. and Siegel, P. (1948) Ärtzl Forsch 2, 245–248.
Killmann, S-Å., Cronkite, E.P., Fliedner, T.M. and Bond, V.P. (1962) Blood 19, 743–750.
Mauer, A.M. (1965) Blood 26, 1–7.
Lasky, L.C., Ascencao, J., McCullough, J. and Zanjian, E.D. (1983) Br. J. Haemotol. 55, 615–622.
Smaaland, R., Laerum, O.D., Lote, K., Sletvold, O., Sothern, R.B. and Bjerknes, R. (1991) Blood 77, 2603–2611.
Smaaland, R., Lote, K., Sletvold, O., Bjerknes, R., Aakvaag, A., Vollset, S.E. and Laerum, O.D. (1991) Ann. NY Acad. Sci. 618, 605–609.
Morra, L., Ponassi, A., Caristo, G., Bruzzi, P., Zunino, R., Parodi, G.B. and Sacchetti, C. (1984) Biomed. Pharmacother. 38, 167–170.
Lund-Johansen, F., Bjerknes, R. and Laerum, O.D. (1990) Cytometry 11, 610–616.
Abrahamsen, J.F., Smaaland, R. and Laerum, O.D. (1994) Amelia Island, Abstract VIIIa-2.
Nelson, W., Tong, Y., Lee, J.K. and Halberg, F. (1979) Chronobiologia 6, 305–323.
Smaaland, R., Abrahamsen, J.F., Svardal, A.M., Lote, K. and Ueland, P.M. (1992) Br. J. Cancer 66, 39–45.
Wide, L., Bengtsson, C. and Birgegard, G. (1989) Br. J. Haematol. 72, 85–90.
Reiter, R.J. (1986) in Endokrinologie der kindheit und Adoleszenz (Gupta, D. ed.) pp. 53–67, Stuttgart, Thieme Verlag.
Aschoff, J. (1979) in Endocrine rhythms (Krieger, D. ed.) pp. 1–67, New York, Raven Press.
Haldar, C., Häusßler, D. and Gupta, D. (1992) J. Pineal Res. 12, 79–93.
Cassone, V.M. (1990) Trends Neurosci. 13, 457–464.
Lampkin, B.C., McWilliams, N.B. and Mauer, A.M. (1976) Br. J. Haematol. 32, 29–40.
Pallavicini, M.G. and Gray, J.W. (1982) Med. Ped. Oncol. 1 (Suppl.), 109–123.
Tannock I. (1978) Cancer Treat. Rep. 62, 1117.
Hill, B.T. (1986) Rec. Results Cancer Res. 103, 41–53.
Simpson-Herren, L. (1982) Ann. NY Acad. Sci. 397, 88–100.
Klevecz, R.R. and Braly, P.S. (1994) in Circadian cancer therapy (Hrushesky, W.J.M. ed.) pp. 165–183, Boca Raton, CRC Press.
Badran, A.F. and Echave-Llanos, J.M. (1965) J. Natl. Cancer Inst. 35, 285.
Voutilainen, A. (1953) Acta Path. Microb. Scan. 99, 1–104.
Tähti, E. (1956) Acta Path. Microbiol. Scand. 117, 1–61.
Stoll, B.A. and Burch, W.M. (1968) Cancer 21, 193–196.
Wolley-Hart, A., Twentyman, P., Corfeild, I., Joslin, C., Morrison, R. and Fowler, J.F. (1986) Br. J. Radiol. 41, 440.
Klevecz, R.R. and Braly, P.B. (1991) Ann. NY Acad. Sci. 618, 257–276.
Braly, P.S. and Klevecz, R.R. (1993) Cancer 71, 1621–1628.
Skipper, H.E., Schabel, F.M.J. and Walcox, W.S. (1967) Cancer Chemother. Res. 51, 125.
Haus, E., Halberg, F., Scheving, L., Cardoso, S., Kuhl, J.F.W., Sothern, R., Shiotsuka, R., Hwang, D. and Pauli, S.E. (1972) Science 177, 80–82.
Scheving, L.E., Haus, E., Kühl, J.F.W., Pauly, J.E., Halberg, F. and Cardoso, S.S. (1976) Cancer Res. 36, 1133–1137.
Scheving, L.E., Burns, R., Pauly, J.E., Halberg, F. and Haus, E. (1977) Cancer Res. 37, 3648–3655.
Sothern, R.B., Nelson, W.L. and Halberg, F.A. (1977) in 12th International Conference of the International Society for Chronobiologypp.433–438, Milano, II Ponte.
Kühl, J.F.K., Haus, E., Halberg, F., Scheving, L.E., Pauly, J.E., Cardoso, S.S. and Rosene, G. (1974) Chronobiologia 1, 316–317.
Scheving, L.E., Burns, E.R., Halberg, F. and Pauly, J.E. (1980) Chronobiologia 17, 33–40.
Scheving, L.E., Burns, E.R., Pauly, J.E. and Halberg, F. (1980) Cancer Res. 40, 1511–1515.
Sothern, R.B., Lévi, F., Haus, E., Halberg, F. and Hrushesky, W.J.M. (1989) J. Natl. Cancer Inst. 81, 135–145.
von Roemeling, R. and Hrushesky, W. (1989) J. Clin. Oncol. 7, 1710–1719.
Hrushesky, W.J.M. (1985) Science 228, 73–75.
Kerr, D.J., Lewis, C., O’Neill, B., Lawson, N., Blackie, R.G., Newell, D.R., Boxall, F., Cox, J., Rankin, E.M. and Kaye, S.B. (1990) Hematol. Oncol. 8, 59–63.
Hrushesky, W.J.M., Roemeling, R.V. and Sothern, R.B. (1989) in Biological rhythms in clinical practice (Arendt, J., Minors, D.S. and Waterhouse, J.M. eds.) pp. 225–252, London, Boston, Singapore, Sydney, Toronto, Wellington., Wright.
Rivard, G.E., Infante-Rivard, C., Hoyoux, C. and Champagne, J. (1985) Lancet 2, 1264–1266.
Rivard, G.E., Infante-Rivard, C., Dresse, M-F., Leclerc, J-M. and Champagne, J. (1993) Chronobiol. Int. 10, 201–204.
Aarnaes, E., Clausen, O.P., Kirkhus, B. and De Angelis, P. (1993) Cell. Proliferation 26, 205–219.
Hrushesky, W.J.M., Langer, R. and Theeuwes, F. (1991) Ann. NY Acad. Sci. 618.
von Roemeling, R. and Hrushesky, W.J.M. (1990) J. Natl. Cancer Inst. 82, 386–393.
Scheving, L.E., Pauly, J.E., Tsai, T.H. and Scheving, L.A. (1983) in Biological Rhythms and Medicine. Cellular, metabolic, physiopathologic, and pharmacologie aspects (Reinberg, A. and Smolensky, M.H. eds.) pp. 79–130, Berlin, New York, Springer-Verlag.
Lévi, F., Halberg, F., Nesbit, M., Haus, E. and Levine, H. (1981) in Neoplasms-Comparative pathology of growth in animals, plants and man (Kaiser, H. ed.) pp. 267–316, Baltimore, Williams & Wilkins.
Focan, C. Le rythme nycthémeral de la prolifération tumorale: Aspects expérimentaux et cliniques: Implication pour la chimiothérapie oncolytique. (1985) Thesis. University of Liège, Belgium.
Smaaland, R., Lote, K., Sothern, R.B. and Laerum, O.D. (1993) Cancer Res. 53, 3129–3138.
Meyn, R.E. and Murray, D. (1986) in Cell. cycle effects of drugs (Dethlefsen, L. A. ed.) 121, pp. 170–188, Oxford, Pergamon Press.
Bhuyan, B.K., Schedit, L.G; and Fraser, T.J. (1972) Cancer Res. 32, 398–407.
Traganos, F., Darzynkiewicz, Z. and Melamed, M.R. (1981) Cancer Res. 41, 4566–4576.
Trasganos, F., Staiano-Coico, L., Darzynkiewicz, Z. and Melamed, M.R. (1981) Cancer Res. 41, 2728-273.
Smaaland, R., Svardal, A.M., Lote, K., Ueland, P.M. and Laerum, O.D. (1991) J. Natl. Cancer Inst. 83, 1092–1098.
Smaaland, R., Laerum, O.D., Sothern, R.B., Sletvold, O., Bjerknes, R. and Lote, K. (1992) Blood 79, 2281–2287.
Brons, P.P.T., Pennings, A.H.M., Haanen, C., Wessels, H.M.C. and Boezeman, J.B.M. (1990) Cytometry 11, 837.
Hrushesky, WJ.M. and Bjarnason, G.A. (1993) in Cancer. Principles and. Practice of Oncology (De Vita, J.V.T., Hellman, S. and Rosenberg, S.A. eds.) Philadelphia., J.B.Lippincott Company.
Ludlum, D. (1977) in Cancer, a comprehensive treatise (Becker, F.F. ed.) 5, pp. 285–307, New York, Plenum Press.
Petit, E., Milano, G., Lévi, F., Thyss, A., Bailleul, F. and Schneider, M. (1988) Cancer Res. 48, 1676–1679.
Mormont, M.C., Boughattas, A.N. and Lévi, F. (1989) in Chronopharmacology. Cellular and biochemical interactions (Lemmer, B. ed.) pp. 395–437, New York, Marcel Dekker.
Boughattas, A.N., Lévi, F., Fournier, C., Lemaigre, G., Roulon, A., Hecquet, B., Mathé, G. and Reinberg, A. (1989) Cancer Res. 49, 3362–3368.
Harris, B., Song, R., Soong, S. and Diasio, R.B. (1989) Cancer Res. 49, 6610–6614.
Boughattas, N.A., Lévi, F., Fournier, C., Hecqet, B., Lemaigre, G., Roulon, A., Mathé, G. and Reinberg, A. (1990) J. Pharmacol Exp. Ther. 255, 672–679.
Paukovits, W.R., Guigon, M., Binder, K.A., Hergl, A., Laerum, O.D. and Schulte-Hermann, R. (1990) Cancer Res. 50, 328–332.
Nienhuis, A.W. (1988) N. Engl. J. Med. 318, 916–918.
Hrushesky, W.J.M. (1987) J. Biol. Response Mod. 6, 587–598.
Lévi, F., Misset, J-L., Brienza, S., Adam, R., Metzger, G., Itzakhi, M., Caussanel, J-P., Kunstlinger, F., Lecouturier, S., Descorps-Declere, A., Jasmin, C., Bismuth, H. and Reinberg, A. (1992) Cancer 69, 893–900.
Lévi, F., Zidani, R., Vannetzel, J-M., Perpoint, B., Focan, C., Faggiuolo, R., Chollet, P., Garufi, C., Itzakhi, M., Dogliotti, L., Iacobelli, S., Adam, R., Kunstlinger, F., Gastiaburu, J., Bismuth, H., Jasmin, C. and Misset, J-L. (1994) J. Natl. Cancer Inst. 86, 1608–1617.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Smaaland, R. (1996). Circadian rhythm of cell division. In: Meijer, L., Guidet, S., Vogel, L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5873-6_23
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5873-6_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7693-4
Online ISBN: 978-1-4615-5873-6
eBook Packages: Springer Book Archive