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The roles of DNA topoisomerase II during the cell cycle

  • Chapter
Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

DNA topoisomerase II (topo II) is essential for survival of all eukaryotic cells. Topo II is both an enzyme and a structural component of the nuclear matrix. It regulates the topological states of DNA by transient cleavage, strand passing and re-ligation of double-stranded DNA resulting in decatenation of intertwined DNA molecules and relaxation of supercoiled DNA. Topo II plays an important role in DNA replication and is required for condensation and segregation of chromosomes. The expression of topo II is cell cycle dependent with both protein levels and catalytic activity peaking at G2/M. Phosphorylation/dephosphorylation of topo II may be a part of regulatory checkpoints at the entry and progression of mitosis.

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Authors and Affiliations

  1. Department of Structural Biology and Pharmacology, Institut Gustave Roussy PR2, Villejuif cedex, 94805, France

    Annette K. Larsen & Andrzej Skladanowski

  2. Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Narutowicza St 11, 80-952, Gdansk, Poland

    Andrzej Skladanowski

  3. Department of Surgery and Pathology, Children’s Hospital and Harvard Medical School, 300 Longwood Ave., 02115, Boston, MA, USA

    Krzysztof Bojanowski

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  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer , Silvana Guidet  & Lee Vogel ,  & 

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© 1996 Springer Science+Business Media New York

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Larsen, A.K., Skladanowski, A., Bojanowski, K. (1996). The roles of DNA topoisomerase II during the cell cycle. In: Meijer, L., Guidet, S., Vogel, L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5873-6_22

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  • DOI: https://doi.org/10.1007/978-1-4615-5873-6_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7693-4

  • Online ISBN: 978-1-4615-5873-6

  • eBook Packages: Springer Book Archive

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