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A Nomenclature System for the Aldo-Keto Reductase Superfamily

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Enzymology and Molecular Biology of Carbonyl Metabolism 6

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 414))

Abstract

The aldo-keto reductases (AKRs) represent a growing superfamily of oxidoreductases (Bohren et al., 1989; Bruce et al., 1994). Proteins of the AKR superfamily are monomeric (α/β)8-barrel proteins, about 320 amino acids in length, which bind NAD(P)(H) without a Rossmann-fold motif (Rondeau et al., 1992; Wilson et al., 1992 > 1995; Hoog et al., 1994, El-Kabbani et al., 1995). Found in mammals, amphibians, plants, yeast, protozoa, and bacteria, the AKRs metabolize a range of substrates including aliphatic aldehydes, monosaccharides, steroids, prostaglandins, polycyclic aromatic hydrocarbons, and isoflavinoid phytoalexins. To date, at least thirty-nine proteins have been cloned and characterized as members of the superfamily, and additional genes have been identified that potentially code for AKR proteins. The rapid progress in identifying new AKRs has lead to some problem in the naming of these proteins.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, 19104, USA

    Joseph M. Jez

  2. Department of Biochemistry, Queen’s University, Ontario, Canada, K7L 3N6

    T. Geoffrey Flynn

  3. Department of Pharmacology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, 19104, USA

    Trevor M. Penning

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  1. Joseph M. Jez
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  2. T. Geoffrey Flynn
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  3. Trevor M. Penning
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Editors and Affiliations

  1. Purdue University, West Lafayette, Indiana, USA

    Henry Weiner

  2. University of South Dakota School of Medicine, Vermillion, South Dakota, USA

    Ronald Lindahl

  3. Indiana University School of Medicine, Indianapolis, Indiana, USA

    David W. Crabb

  4. Queen’s University, Kingston, Ontario, Canada

    T. Geoffrey Flynn

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Jez, J.M., Flynn, T.G., Penning, T.M. (1996). A Nomenclature System for the Aldo-Keto Reductase Superfamily. In: Weiner, H., Lindahl, R., Crabb, D.W., Flynn, T.G. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 6. Advances in Experimental Medicine and Biology, vol 414. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5871-2_66

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  • DOI: https://doi.org/10.1007/978-1-4615-5871-2_66

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