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Regulation of Interleukin-12 Signalling During T Helper Phenotype Development

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New Horizons in Allergy Immunotherapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 409))

Abstract

During antigen activation, helper T cells differentiate to stable phenotypes characterized by production of specific cytokines (1,2). The T helper type 1 (Thl) phenotype is characterized by high levels of interferon-γ (IFNγ) and lymphotoxin production. Thl development stimulates cell-mediated immune responses, including macrophage activation, and the production of restricted immunoglobulin isotypes such as IgG2a (3). The Th2 phenotype correlates with roduction of interleukin-4 (IL-4), IL-5, and IL-10, which stimulate humoral responses, including B cell and eosinophil activation, as well as the production of other immunoglobulin isotypes such as IgE (4,5).

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Author information

Authors and Affiliations

  1. Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Nils G. Jacobson, Susanne J. Szabo, Mehmet L. Güler, James D. Gorham & Kenneth M. Murphy

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  1. Nils G. Jacobson
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  2. Susanne J. Szabo
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  3. Mehmet L. Güler
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  4. James D. Gorham
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  5. Kenneth M. Murphy
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Editor information

Editors and Affiliations

  1. University of Manitoba, Winnipeg, Manitoba, Canada

    Alec Sehon  & Kent T. HayGlass  & 

  2. Institute of General and Experimental Pathology, Vienna, Austria

    Dietrich Kraft

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© 1996 Springer Science+Business Media New York

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Jacobson, N.G., Szabo, S.J., Güler, M.L., Gorham, J.D., Murphy, K.M. (1996). Regulation of Interleukin-12 Signalling During T Helper Phenotype Development. In: Sehon, A., HayGlass, K.T., Kraft, D. (eds) New Horizons in Allergy Immunotherapy. Advances in Experimental Medicine and Biology, vol 409. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5855-2_9

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  • DOI: https://doi.org/10.1007/978-1-4615-5855-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7684-2

  • Online ISBN: 978-1-4615-5855-2

  • eBook Packages: Springer Book Archive

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