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Oxygen Tension in Primary Tumours of the Uterine Cervix and Lymph Node Metastases of the Head and Neck

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Oxygen Transport to Tissue XIX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 428))

Abstract

Tumours often show low oxygen concentrations due to abnormal delivery and meta-bolism of oxygen (Vaupel et al., 1989; Gulledge and Dewhirst, 1996). The vascular net-work is highly irregular with large intercapillary distances leading to impaired blood supply. The capacity of the blood to carry oxygen is reduced because of low extracellular pH. Moreover, the oxygen demand is elevated due to the high proliferation activity of tu-mour cells. These characteristics lead to the development of hypoxic and necrotic areas within tumours. However, the oxygen concentration can differ considerably among differ-ent tumours, even among tumours of the same histological type.

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Author information

Authors and Affiliations

  1. Department of Biophysics, Institute for Cancer Research, Oslo, Norway

    Heidi Lyng & Einar K. Rofstad

  2. Department of Gynecology, The Norwegian Radium Hospital, Oslo, Norway

    Kolbein Sundfør

  3. Department of Oncology, The Norwegian Radium Hospital, Oslo, Norway

    Gunnar Tanum

Authors
  1. Heidi Lyng
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  2. Kolbein Sundfør
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  3. Gunnar Tanum
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  4. Einar K. Rofstad
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Editor information

Editors and Affiliations

  1. Ninewells Hospital and Medical School, Dundee, Scotland

    David K. Harrison

  2. University College London, London, England

    David T. Delpy

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© 1997 Springer Science+Business Media New York

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Lyng, H., Sundfør, K., Tanum, G., Rofstad, E.K. (1997). Oxygen Tension in Primary Tumours of the Uterine Cervix and Lymph Node Metastases of the Head and Neck. In: Harrison, D.K., Delpy, D.T. (eds) Oxygen Transport to Tissue XIX. Advances in Experimental Medicine and Biology, vol 428. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5399-1_9

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  • DOI: https://doi.org/10.1007/978-1-4615-5399-1_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7465-7

  • Online ISBN: 978-1-4615-5399-1

  • eBook Packages: Springer Book Archive

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