Abstract
Pyrimidines and purines are constituents of nucleic acids, but they also play an important role in other aspects of metabolism. The sizes of their pools in the cell are determined by de novo biosynthetic, salvage and catabolic pathways. While the de novo biosynthetic and salvage pathways are relatively well characterized, so far very little is known about the degradation of pyrimidines and purines at the genetic level.
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References
Glatigny A. and Scazzocchio C., 1995, Cloning and molecular characterization of hxA, the gene coding for the xanthine dehydrogenase (purine hydroxylase I) of Aspergillus nidulans. J. Biol. Chem. 270: 3534–3550.
Lara F.J.S., 1952, On the decomposition of pyrimidines by bacteria. I. Studies by means of the technique of simultaneous adaptation J. Bacteriol. 64: 271–277.
LaRue T.A. and Spencer J.F.T., 1968, The utilization of purines and pyrimidines by yeasts. Can.J.Microbiol. 14: 79–86.
Nygaard P., Duckert P., and Saxild H.H., 1996, Role of adenine deaminase in purine salvage and nitrogen metabolism and characterization of the ade gene in Bacillus subtilis. J.Bacteriol. 178: 846–853.
Oestreicher N. and Scazzocchio C., 1993,Sequence, regulation and mutational analysis of the gene encoding urate oxidase in Aspergillus nidulans. J.Biol.Chem. 268: 23382–23389.
Piskur J., Kolbak D., Søndergaard L. and Pedersen M.B., 1993, The dominant mutation Suppressor of black indicates that de novo pyrimidine biosynthesis is involved in the Drosophila tan pigmentation pathway. Mol. Gen. Genet. 241: 335–340.
Traut T.W. and Loechel S., 1984, Pyrimidine catabolism: individual characterization of the three sequential enzymes with a new assay. Biochemistry 23: 2533–2539.
Weinstock K.G. and Strathern J.N., 1993, Molecular genetics in Saccharomyces kluyveri: the HIS3 homolog and its use as selectable marker gene in S. kluyveri and Saccharomyces cerevisiae. Yeast 9: 351–361.
Wright R.M., Vaitaitis G.M., Wilson C.M., Repine T.B., Terada L.S. and Repine J.E., 1993, cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase. Proc. Natl. Acad. Sci. USA 90: 10690–10694.
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© 1998 Springer Science+Business Media New York
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Gojkovic, Z., Paracchini, S., Piskur, J. (1998). A New Model Organism for Studying the Catabolism of Pyrimidines and Purines. In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_94
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DOI: https://doi.org/10.1007/978-1-4615-5381-6_94
Publisher Name: Springer, Boston, MA
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