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Cyclosporine Distribution into the Conjunctiva, Cornea, Lacrimal Gland, and Systemic Blood Following Topical Dosing of Cyclosporine to Rabbit, Dog, and Human Eyes

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 438))

Abstract

Cyclosporine is an immune modulator that inhibits T-lymphocyte-mediated immunoreactivity. Allergan is currently evaluating the clinical efficacy of 0.05%–0.4% cyclosporine emulsion for the treatment of immuno-inflammatory eye diseases, such as keratoconjunctivitis sicca, or dry eye syndrome. Topical ocular application of cyclosporine, formulated as 2% cyclosporine in olive oil, 0.2% cyclosporine in corn oil ointment (Schering-Plough), or 0.2% cyclosporine emulsion (Allergan), was found to reduce ocular surface inflammation and improve lacrimal gland secretion in dogs with KCS.1–3

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References

  1. Kaswan RL. Spontaneous canine keratoconjunctivitis, a useful model for human keratoconjunctivits sicca: Treatment with cyclosporine eyedrops. Arch Ophthalmol. 1989;107:1210–1216.

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  2. The 0.2% cyclosporine ointment is marketed by Schering-Plough for treatment of keratoconjunctivitis sicca in dogs.

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Author information

Authors and Affiliations

  1. Allergan, Irvine, California, USA

    Andrew Acheampong, Martha Shackleton, Steve Lam, Patrick Rudewicz & Diane Tang-Liu

Authors
  1. Andrew Acheampong
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  2. Martha Shackleton
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  3. Steve Lam
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  4. Patrick Rudewicz
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  5. Diane Tang-Liu
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Editor information

Editors and Affiliations

  1. The Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  2. Louisiana State University Medical Center, New Orleans, Louisiana, USA

    Michele A. Meneray

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© 1998 Springer Science+Business Media New York

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Acheampong, A., Shackleton, M., Lam, S., Rudewicz, P., Tang-Liu, D. (1998). Cyclosporine Distribution into the Conjunctiva, Cornea, Lacrimal Gland, and Systemic Blood Following Topical Dosing of Cyclosporine to Rabbit, Dog, and Human Eyes. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_144

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  • DOI: https://doi.org/10.1007/978-1-4615-5359-5_144

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7445-9

  • Online ISBN: 978-1-4615-5359-5

  • eBook Packages: Springer Book Archive

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