Abstract
Sjögren’s syndrome is an autoimmune exocrinopathy involving primarily the salivary and lacrimal glands. The secondary form of this disorder consists of exocrine involvement (the sicca syndrome) in an individual with another connective tissue disease. The most common associated condition is rheumatoid arthritis. Primary Sjögren’s syndrome is characterized by exocrine involvement alone. Although there is more restricted tissue involvement in primary Sjögren’s syndrome, this is a systemic condition, as evidenced by prominent serological evidence of autoimmune reactivity, including high titer autoantibodies (anti-nuclear antibodies [ANA], rheumatoid factors [RF], SS-A/Ro, SS-A/La) and hypergammaglobulinemia in the majority of patients. There is also an increased incidence of lymphoma.
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Fox, P.C., Grisius, M.M., Bermudez, D.K., Sun, D. (1998). Cytokine mRNA Expression in Labial Salivary Glands and Cytokine Secretion in Parotid Saliva in Sjögren’s Syndrome. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_129
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DOI: https://doi.org/10.1007/978-1-4615-5359-5_129
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