Abstract
The development of new retroviral vectors allowed the transfer and expression of different genes, including those of cytokines, in both lymphocytes and tumor cells (1). It has been shown by several groups that the expression of many cytokines by tumor cells can render them more immunogeneic to the host (2).
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Belli, F. et al. (1998). Active Immunization of Metastatic Melanoma Patients with IL-2 or IL-4 Gene Transfected, Allogeneic Melanoma Cells. In: Walden, P., Trefzer, U., Sterry, W., Farzaneh, F., Zambon, P. (eds) Gene Therapy of Cancer. Advances in Experimental Medicine and Biology, vol 451. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5357-1_84
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DOI: https://doi.org/10.1007/978-1-4615-5357-1_84
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