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Development of CD4+ Effector T Cells and Susceptibility to Infectious Diseases

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Mechanisms of Lymphocyte Activation and Immune Regulation VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 452))

Abstract

The mechanisms by which naive helper T cells differentiate into potent cytokine-expressing effectors remain critical to understanding both successful and aberrant immune responses. Studies using Leishmania major infection of mice have revealed genetic contributions to factors that influence this differentiative process. Further, antigen recognition at the level of the T cell repertoire can also profoundly affect the outcome of disease and the appearance of discrete T cell subsets. It is likely that such mechanisms also underpin genetic susceptibility to diverse other infectious and autoimmune diseases.

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Author information

Authors and Affiliations

  1. Departments of Medicine, Microbiology/Immunology and the Howard Hughes Medical Institute, University of California, San Francisco, California, 94143-0654, USA

    Richard M. Locksley, Deborah J. Fowell, Kanade Shinkai, Adil E. Wakil, Dee Lacy & Mark Bix

Authors
  1. Richard M. Locksley
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  2. Deborah J. Fowell
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  3. Kanade Shinkai
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  4. Adil E. Wakil
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  5. Dee Lacy
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  6. Mark Bix
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Corresponding author

Correspondence to Richard M. Locksley .

Editor information

Editors and Affiliations

  1. University of California, Irvine, Irvine, California, USA

    Sudhir Gupta

  2. National Institutes of Health, Bethesda, Maryland, USA

    Alan Sher

  3. Emory University, Atlanta, Georgia, USA

    Rafi Ahmed

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© 1998 Springer Science+Business Media New York

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Locksley, R.M., Fowell, D.J., Shinkai, K., Wakil, A.E., Lacy, D., Bix, M. (1998). Development of CD4+ Effector T Cells and Susceptibility to Infectious Diseases. In: Gupta, S., Sher, A., Ahmed, R. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VII. Advances in Experimental Medicine and Biology, vol 452. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5355-7_6

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  • DOI: https://doi.org/10.1007/978-1-4615-5355-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7443-5

  • Online ISBN: 978-1-4615-5355-7

  • eBook Packages: Springer Book Archive

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