Abstract
In Parkinson’s disease, a progressive degeneration of nigro-striatal dopaminergic neurons results in akinesia, muscular rigidity and tremor. MPTP (l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a neurotoxin that is responsible for the Parkinson-like symptoms seen in humans using illicit synthetic opiate analogs of meperidine containing MPTP as a contaminant (Langston et al., 1983). Rodents are highly susceptible to the neurotoxic effects of MPTP and may be useful animal models for Parkinson’s disease (Hallmann et al., 1985; Takada et al., 1987). Administration of MPTP to rodents results in a significant loss of nervous cells in the substantia nigra (Takada et al., 1987) and a marked reduction in neostriatal content of dopamine and its metabolites (Heikkila et al., 1984; Fuller and Hemrick-Luecke, 1984).
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Gulyaeva, N.V. et al. (1998). Interval Hypoxic Training Prevents Oxidative Stress in Striatum and Locomotor Disturbances in a Rat Model of Parkinsonism. In: Fisher, A., Hanin, I., Yoshida, M. (eds) Progress in Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5337-3_102
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DOI: https://doi.org/10.1007/978-1-4615-5337-3_102
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