Skip to main content

Inhibition of Mammary Cancer by Citrus Flavonoids

  • Chapter
Flavonoids in the Living System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 439))

Abstract

Much of the emphasis in research on diet and cancer has been focused on the promotion of cancer by dietary fat (Carroll, 1994). However, the lack of support for the fat hypothesis by case-control and cohort studies has led people to question its validity (Land, 1994; Hunter et al., 1996). Epidemiological studies on diet and cancer have provided leads in the search for naturally-occurring anticancer agents (Steinmetz and Potter, 1991a; Block et al., 1992). There is general agreement that plant-based diets, rich in whole grains, legumes, fruits and vegetables reduce the risk of various types of cancer, including breast cancer. A variety of compounds produced by plants have been investigated (Steinmetz and Potter, 1991b; Wattenburg, 1992). These include the flavonoids, which are an integral part of the human diet.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Akiyama, T.; Ishida, J.; Nakagawa, S.; Ogawara, H.; Watanabe, S.; Itoh, N.; Shibuya, M.; Fukami, Y. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 1987, 262, 5592–5595.

    PubMed  CAS  Google Scholar 

  • Adlercreutz, H; Honjo, H.; Higashi, A.; Fotsis, T.; Hamalainen, E.; Hasegawa, T.; Okada, H. Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. Am. J. Clin. Nutr. 1991, 54, 1093–1100.

    PubMed  CAS  Google Scholar 

  • Bailey, D.G.; Spence, J.D.; Munoz, C.; Arnold, J.M.O. Interaction of citrus juices with felodipine and nifedipine. Lancet 1991, 337, 268–269.

    Article  PubMed  CAS  Google Scholar 

  • Barnes, S. Effect of genistein on in vitro and in vivo models of cancer. J. Nutr. 1995, 125, 777S–783S.

    PubMed  CAS  Google Scholar 

  • Block, G.; Patterson, B.; Subar, A. Fruits, vegetables and cancer prevention: A review of the epidemiological evidence. Nutr. Cancer 1992, 18, 1–29.

    Article  PubMed  CAS  Google Scholar 

  • Boege, F.; Straub, T.; Kehr, A.; Boesenberg, C.; Christiansen, K.; Anderson, A.; Jakob, F.; Kohrle, J. Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I. J. Biol. Chem. 1996, 271(4), 2262–2270.

    Article  PubMed  CAS  Google Scholar 

  • Carroll, K.K. Lipids and cancer. In Nutrition and Disease Update. Cancer, Carroll, K.K.; Kritchevsky, D., Eds.; AOCS Press: Champaign, IL, 1994; pp 235–296.

    Google Scholar 

  • Carroll, K.K.; Guthrie, N.; Nesaretnam, K.; Gapor, A.; Chambers, A.F. Anti-cancer properties of tocotrienols from palm oil. In Nutrition, Lipids, Health, and Disease; Ong, A.S.H.; Niki, E.; Packer, L., Eds.; AOCS Press, Champaign, IL, 1995; pp. 117–121.

    Google Scholar 

  • Carroll, K.K.; Guthrie, N.; So, F.V.; Chambers, A.F. Anti-cancer properties of flavonoids, with emphasis on citrus flavonoids. In Flavonoids in Health and Disease; Rice-Evans, C.; Packer, L. Eds.; Marcel Dekker, Inc., New York, 1998; pp. 437–446.

    Google Scholar 

  • Edwards, J.M.; Mori, A.; Nishino, C; Enoki, N.; Tawata, S. Cytotoxicity of plant flavonoids against Hela cells. Phytochemistry 1988, 27, 1017–1020.

    Article  Google Scholar 

  • Ferriola, P.C.; Cody, V.; Middleton, E. Jr. Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships. Biochem. Pharmacol., 1989, 38, 1617–1624.

    Article  PubMed  CAS  Google Scholar 

  • Guthrie, N.; Gapor, A.; Chambers, A.F.; Carroll, K.K. Palm oil tocotrienols and plant flavonoids act synergistically with each other and with tamoxifen in inhibiting proliferation and growth of estrogen receptor-negative MDA-MB-435 and-positive MCF-7 human breast cancer cells in culture. Asia Pacific J. Clin. Nutr. 1997a, 6, 41–45.

    Google Scholar 

  • Guthrie, N.; Gabor, A.; Chambers, A.F.; Carroll, K.K. Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and-positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in combination. J. Nutr. 1997b, 127, 544S–548S.

    PubMed  CAS  Google Scholar 

  • Guthrie, N.; Moffatt, M.; Chambers, A.F.; Spence, J.D.; Carroll, K.K. Inhibition of proliferation of human breast cancer cells by naringenin, a flavonoid in grapefruit. Abst. Natl. Forum Breast Cancer, Montreal, PQ, 1993, p 118.

    Google Scholar 

  • Guthrie, N.; Gapor, A.; Chambers, A.F.; Carroll, K.K. Inhibition of protein kinase C in MDA-MB-435 human breast cancer cells by palm oil tocotrienols. Proc. Can. Fed. Biol. Soc. 1996, 39, Abstract 262.

    Google Scholar 

  • Hansen, M.B.; Nielsen, S.E.; Berg, K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 1989, 119, 203–210.

    Article  PubMed  CAS  Google Scholar 

  • Hertog, M.G.L.; Hollman, P.C.H.; Katan, M.B.; Kromhout, D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr. Cancer 1993, 20, 21–29.

    Article  PubMed  CAS  Google Scholar 

  • Hunter, D.J.; Spiegelman, D.; Adami, H.-O. et al. Cohort studies of fat intake and risk of breast cancer: a pooled analysis. N. Engl. J. Med. 1996, 334, 356–361.

    Article  PubMed  CAS  Google Scholar 

  • Jordan, V.C. Tamoxifen and tumorigenicity: a predictable concern. J. Natl. Cancer hist. 1995, 87, 623–626.

    Article  CAS  Google Scholar 

  • Jordan, V.C. Long-term tamoxifen treatment for breast cancer. J. Natl. Cancer Inst. 1995, 87, 1176–1177.

    Article  Google Scholar 

  • Kuhnau, J. The flavonoids. A class of semi-essential food components: Their role in human nutrition. World Rev. Nutr. Diet 1976, 24, 117–191.

    PubMed  CAS  Google Scholar 

  • Levy, J.; Teuerstein, I.; Marbach, M.; Radian, S.; Sharoni, Y. Tyrosine protein kinase Activity in the DMBA-induced rat mammary tumor:inhibition by quercetin. Biochem. Biophys. Res. Commun. 1984, 123, 1227–1233.

    Article  PubMed  CAS  Google Scholar 

  • Lund, E. The research tide ebbs for the dietary fat hypothesis in breast cancer. Epidemiology 1994, 5, 387–388.

    Article  PubMed  CAS  Google Scholar 

  • Messina, M.J.; Persky, V.; Setchell, K.D.R.; Barnes, S. Soy intake and cancer risk:a review of the in vitro and in vivo data. Nutr. Cancer 1994, 21, 113–131.

    Article  PubMed  CAS  Google Scholar 

  • Messina, M.; Erdman, J.W. Jr., Eds. First international symposium on the role of soy in preventing and treating chronic disease. J. Nutr 1995, 125, 567s–569s.

    Google Scholar 

  • Middleton, E. Jr.; Kandaswami, C. Potential health-promoting properties of citrus flavonoids. Food Technol. 1994a, 48(11), 115–119.

    CAS  Google Scholar 

  • Middleton, E.; Kandaswami, C. The impact of plant flavonoids on mammalian biology:implications for immunity, inflammation and cancer. In The Flavonoids: Advances in Research Since 1986; Harborne, J.B., Ed.; Chapman and Hall, London, 1994b; pp. 619–652.

    Google Scholar 

  • Mookerjee, B.K.; Lee, T.-P.; Lippes, H.A.; Middleton, E. Jr. Some effects of flavonoids on lymphocyte proliferative responses. J. Immun. Pharmacol. 1986, 8, 371–392.

    Article  CAS  Google Scholar 

  • Nesaretnam, K.; Guthrie, N.; Chambers, A.F.; Carroll, K.K. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 1995, 30, 1139–1143.

    Article  PubMed  CAS  Google Scholar 

  • Peterson, G.; Barnes, S. Genistein inhibition of the growth of human breast cancer cells: independence from the estrogen receptors and the multi-drug resistance gene. Biochem. Biophys. Res. Commun. 1991, 179, 661–667.

    Article  PubMed  CAS  Google Scholar 

  • Pelissero, C.; Lenczowski, M.J.; Chinzi, D.; Davail-Cuisset, B.; Sumpter, J.P.; Fostier, A. Effects of flavonoids on aromatase activity, an in vitro study. J. Steroid Biochem. Mol. Biol. 1996, 57, 215–223.

    Article  PubMed  CAS  Google Scholar 

  • Raffauf, R.F.; Le Quesne, P.W. Antineoplastic activity and cytotoxicity of flavones, soflavones, and flavonones. J. Nat. Prod. 1919, 42, 85–91.

    Google Scholar 

  • Ramanathan, R.; Tan, C.H.; Das, N.P. Cytotoxic effect of plant polyphenols and fat-soluble vitamins on malignant human cultured cells. Cancer Lett. 1992, 62, 217–224.

    Article  PubMed  CAS  Google Scholar 

  • Sharoni, Y.; Teuerstein, I.; Levy, J. Phosphoinositide phosphorylation precedes growth in rat mammary tumors. Biochem. Biophys. Res. Commun. 1998, 134, 876–882.

    Article  Google Scholar 

  • Singhal, R.L.; Yeh, Y.A.; Prajda, N.; Olah, E.; Sledge, G.W. Jr.; Weber, G. Quercetin down regulates signal transduction in human breast carcinoma. Biochem. Biophys. Res. Commun. 1995, 208, 425–431.

    Article  PubMed  CAS  Google Scholar 

  • So, F.V.; Guthrie, N.; Chambers, A.F.; Moussa, M.; Carroll, K.K. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr. Cancer 1996a, 26, 167–181.

    Article  PubMed  CAS  Google Scholar 

  • So, F.V. Dietary flavonoids and breast cancer: in vitro, in vivo and mechanism studies. M.Sc. Thesis, 1996b; The Univ. of Western Ontario, London, Ontario.

    Google Scholar 

  • So, F.V.; Guthrie, N.; Chambers, A.F.; Carroll, K.K. Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen. Cancer Lett. 1991,112, 127–133.

    Article  Google Scholar 

  • Steinmetz, K.A.; Potter, J.D. Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes Control 1991a, 2, 325–357.

    Article  PubMed  CAS  Google Scholar 

  • Steinmetz, K.A.; Potter, J.D. Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes Control 1991b, 2, 427–442.

    Article  PubMed  CAS  Google Scholar 

  • Verma, A.K.; Johnson, J.A.; Gould, M.N.; Tanner, M.A. Inhibition of 7,12-dimethylbenz[a]anthracene-and n-nitrosomethylurea-induced rat mammary cancer by the dietary flavonol quercetin. Cancer Res. 1988, 48, 5754–5758.

    PubMed  CAS  Google Scholar 

  • Wattenburg, L.W. Inhibition of carcinogenesis by minor dietary constituents. Cancer Res. 1992, 52, 2085s–2091s.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Guthrie, N., Carroll, K.K. (1998). Inhibition of Mammary Cancer by Citrus Flavonoids. In: Manthey, J.A., Buslig, B.S. (eds) Flavonoids in the Living System. Advances in Experimental Medicine and Biology, vol 439. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5335-9_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-5335-9_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7434-3

  • Online ISBN: 978-1-4615-5335-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics