Abstract
The roles of CD4+ T cells, IFN-γ and TNF-α in viral clearance from the central nervous system (CNS) were examined in perforin gene deficient (PKO) mice. Depletion of CD4+ T cells from the PKO mice resulted in a significant 1 log10 PFU/gm increase in viral titer over control-treated PKO mice. PKO mice treated with anti-IFN-α mAb also had a significant 1 log10 increase in infectious virus whereas inhibition of TNF-a did not alter viral clearance or clinical disease in the PKO mice. These data suggest, in addition to perforin-mediated cytolysis, CD4+ T cells and IFN-γ, but not TNF-α could contribute to JHMV clearance from the CNS.
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Lin, M.T., Hinton, D.R., Stohlman, S.A. (1998). Mechanisms of Viral Clearance in Perforin-Deficient Mice. In: Enjuanes, L., Siddell, S.G., Spaan, W. (eds) Coronaviruses and Arteriviruses. Advances in Experimental Medicine and Biology, vol 440. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5331-1_54
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DOI: https://doi.org/10.1007/978-1-4615-5331-1_54
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