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Current Status of Knowledge and Critical Issues in Tumor Oxygenation

Results from 25 Years Research in Tumor Pathophysiology

  • Chapter
Oxygen Transport to Tissue XX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 454))

Abstract

In 1972 we started the systematic investigation of oxygenation status in (a) experimental tumor systems in rats and mice [e.g., 1–6], (b) in human tumors xenotransplanted into immune-deficient rnu/rnu-rats [e.g., 7–9], (c) in tumors derived from spontaneously tumorigenic or ras-transformed cell lines [10], and (d) in human tumors in situ [e.g., 11–15] under various pathophysiological conditions using polarographic O2 needle electrodes. In the earlier studies a cryospectrophotometric ex vivomicrotechnique was also used that allowed the measurement of HbO2 saturation in individual red blood cells in tumor microvessels [e.g., 16, 17]. Besides polarographic and cryospectrophotometric microtechniques, mathematical evaluations of the pO2 distribution in tumor tissues have additionally been used to gain an insight into the oxygenation of microareas in tumor tissues [e.g., 18–21].

Supported by the Deutsche Krebshilfe (Grant 70-1920-Va 2).

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Authors and Affiliations

  1. Institute of Physiology and Pathophysiology, Germany

    P. Vaupel, O. Thews & D. K. Kelleher

  2. Department of Obstetrics and Gynecology, University of Mainz, D-55099, Mainz, Germany

    M. Hoeckel

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  1. P. Vaupel
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  2. O. Thews
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Editors and Affiliations

  1. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Antal G. Hudetz

  2. University of Maryland, Baltimore County, Baltimore, Maryland, USA

    Duane F. Bruley

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Vaupel, P., Thews, O., Kelleher, D.K., Hoeckel, M. (1998). Current Status of Knowledge and Critical Issues in Tumor Oxygenation. In: Hudetz, A.G., Bruley, D.F. (eds) Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology, vol 454. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4863-8_70

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