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Indomethacin Inhibition of Pristane Plasmacytomagenesis in Genetically Susceptible Inbred Mice

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 469))

Abstract

In the peritoneal plasmacytomagenesis (PCTG) model system, plasmacytomas (PCTs) are induced when different kinds of metabolically inert substances (paraffin oils, silicones, polycarbonate solid discs) are introduced into the peritoneal cavities of genetically susceptible BALB/cAn mice. The PCTs develop morphologically in the chronic inflammatory tissue that forms in peritoneal connective tissues in response to these agents. The most extensively studied agent is pristane (2,6,10,14-tetramethylpentadecane)1,2. This induction system has been useful in identifying steps and biological determinants in plasma cell neoplasia. Important features of pristane PCTG in the mouse are: 1) the remarkable dependence on the BALB/cAn genotype and, specifically, the chromosome-4 PCT susceptibility genes Pctr 1 and Pctr23,4; 2) the consistent (>95%) appearance of chromosomal translocations t(6;15)or t(12;15) that are associated with rearrangement of Immunoglobulin (Ig) genes and c-myc and result in the deregulation of c-myc transcription5,6; 3) the influence of natural antigenic stimulation [Specific Pathogen Free BALB/cAnPt mice that have a very restricted exposure to environmental antigens are resistant to PCT induction by pristane7]; 4) the dependence upon the special vascular and immunological properties of the peritoneal space8; and 5) the dependence for growth and progression on the reactive chronic inflammatory microenvironments and cytokines, e.g., IL-69–11.

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Author information

Authors and Affiliations

  1. Laboratory of Genetics National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

    Michael Potter

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  1. Michael Potter
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Editor information

Editors and Affiliations

  1. Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Lawrence J. Marnett

  3. Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. University of California at San Diego, San Diego, California, USA

    Edward A. Dennis

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© 1999 Springer Science+Business Media New York

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Potter, M. (1999). Indomethacin Inhibition of Pristane Plasmacytomagenesis in Genetically Susceptible Inbred Mice. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_23

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  • DOI: https://doi.org/10.1007/978-1-4615-4793-8_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7171-7

  • Online ISBN: 978-1-4615-4793-8

  • eBook Packages: Springer Book Archive

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