Abstract
Under normal circumstances, the bladder fills with little or no increase in intravesical pressure. When the volume capacity is reached, afferent signals, likely from stretch receptors associated with nerve endings, trigger the micturition reflex. The bladder then systematically empties and a new filling cycle begins. During each cycle, there must be a close integration of tension generating (muscle cells or “active” elements) with tension bearing and elastic elements (collagen and elastin), that are passive structural components.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Mallory, B., Steers, W. and de Groat, W.C.: Electrophysiological study of micturition refelxes in the rat. Amer. J. Physiol., 257: R410, 1989.
Cass, S.C. and Hinman, F.: Constant urethral flow in female dog. II Effect of consrtiction of vesical neck and external meatus. J. Urol., 99: 447, 1976.
Uvelius, B., Peterson, L. and Mattiasson, A.: Smooth muscle hypertrophy and hyperplasia in the rat detrusor after short-term infravesical outflow obstruction. J.Urol., 131: 173, 1984.
Levin, R. M., High, H. and Wein, A.J.: The effect of short-term obstruction on urinary bladder function in the rabbit. J. Urol., 132: 789, 1984.
Kim, K.M., Kogan, B.A., Massad, C.A. and Hyang, Y-C.: Collagen and elastin in the obstructed fetal bladder. J. Urol., 146: 528, 1991.
Nielsen, K.K., Andersen, C.B., Petersen, L.K., Oxlund, H. and Nordling, J.: Morphological, stereological and biochemical analysis of the mini-pig urinary bladder after chronic outflow obstruction and after recovery from obstruction. Neurourology and Urodynamics., 14: 269, 1995.
Elbadawi, A.: Pathology and pathophysiology of detrusor in incontinence. Urologie Clinics of North American., 22: 499, 1995.
Levin, R.L.: Developmental aspects of urinary bladder physiology and pharmacology. In: Dialogues in Pediatric Urology, Ed Richard Ehrlich, William J. Miller Assoc.,Inc, Pearl River, New York, pp2, 1996.
Sachs, F.: Mechanical transduction by ion channels: how forces reach the channel. Society of General Physiologists Series., 52: 209, 1997.
Chen, M-W., Levin, R.M. and Buttyan, R.: Peptide growth factors in normal and hypertrophied bladder. World J. Urol., 13: 344, 1995.
Gabella, G. and Uvelius, B.: Reversal of muscle hypertrophy in the rat urinary bladder after removal of urethral obsrtuction. Cell Tissue Res., 277: 333, 1994.
Ewalt, D.H., Howard, P.S., Blyth, B., Snyder, HM 3d., Duckett, J.W., Levin R.M. and Macarak E.J.: Is lamina propria matrix reponsible for normal bladder compliance? J. Urol., 148: 544, 1992.
Deveaud, C.M., Macarak, E.J., Kucich, U., Ewalt, D.H., Abrams, W.R. and Howard, P.S.: Molecular analysis of collagens in bladder fibrosis. J. Urol. In press, 1998.
Chang, S.L., Howard, P.S. and Macarak, E.J..: Role of type III collagen in bladder filling. Neurology and urodynamics. in press, 1998.
Keene, D.R., Sakai, L. Y., Bachinger, H.P. and Burgeson, R.E.: Type II collagen can be present on banded collagen fibrils regardless of fibril diameteer. J. Of cell Biol., 105: 2393, 1987.
Close, C.E., Carr, M. C., Burns, M. W. and Mitchell, M.E.: Lower urinary tract changes after early valve ablation in neonates and infants: is early diversion warranted? J. Urol., 157: 984, 1997.
Liu, X., Wu, H., Byrne, M., Krane, S. and Jaenisch, R.: Type III collagen is crucial for collagen I fibrillo-genesis and for normal cardiovascular development. Proc. Nat. Acad. Sci. USA., 94: 1852, 1997.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media New York
About this chapter
Cite this chapter
Macarak, E.J., Howard, P.S. (1999). The Role of Collagen in Bladder Filling. In: Baskin, L.S., Hayward, S.W. (eds) Advances in Bladder Research. Advances in Experimental Medicine and Biology, vol 462. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4737-2_17
Download citation
DOI: https://doi.org/10.1007/978-1-4615-4737-2_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7147-2
Online ISBN: 978-1-4615-4737-2
eBook Packages: Springer Book Archive