Abstract
Lipid peroxidation produces several toxic carbonyl compounds including alpha-beta unsaturated aldehydes (Dianzani, 1982). Lipid peroxidation also occurs under physiological conditions, particularly in cells that are not rapidly proliferating (Esterbauer et al., 1991). By contrast, proliferating neoplastic cells, such as K562 and HL-60 do not show detectable levels of lipid peroxidation even if exposed to prooxidants, and their endogenous production of aldehydes is, therefore, very low (Dianzani, 1993).
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Barrera, G., Pizzimenti, S., Muzio, G., Maggiora, M., Dianzani, M.U., Canuto, R.A. (1999). Enzymes Metabolizing Aldehydes in HL-60 Human Leukemic Cells. In: Weiner, H., Maser, E., Crabb, D.W., Lindahl, R. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 7. Advances in Experimental Medicine and Biology, vol 463. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4735-8_65
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DOI: https://doi.org/10.1007/978-1-4615-4735-8_65
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