Abstract
Protein C (PC) is a vitamin K-dependent plasma zymogen produced in the liver. It is present at a concentration of 4.0μg/ml in normal plasma and, importantly, acts as both a potent anticoagulant and antithrombotic. The major activator of PC is thrombin that is formed during blood coagulation. Activation occurs on the surface of endothelial cells by means of a complex with thrombin and thrombomodulin. The PC exhibits its anti-coagulating ability by cleaving activated co-factors V and VIII into inactive fragments. This proteolytic cleavage requires, among other things, protein S and Ca++. The PC exhibits its antithrombotic nature by stimulating fibrinolysis through the indirect activation of plasminogen (Esmon et al., 1995, Reltsma, 1997).
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© 1999 Springer Science+Business Media New York
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Spiker, J.O., Drohan, W.N., Kang, K.A. (1999). Reusability Study of Fiber Optic Based Protein C Biosensor. In: Eke, A., Delpy, D.T. (eds) Oxygen Transport to Tissue XXI. Advances in Experimental Medicine and Biology, vol 471. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4717-4_84
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DOI: https://doi.org/10.1007/978-1-4615-4717-4_84
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