Abstract
Diffusion of oxygen to tissue has been well studied, mainly by means of mathematical models. The effect of blood flow on oxygen supply to the muscle has been widely explored for almost a century since the first studies of Krogh. Nevertheless, a number of problems of hard work, such as muscle hypoxia under load as a function of local conditions, are not clearly understood (Saltin and Rowell, 1980; Ivanov, 1993; Convertino, 1996). We reasoned to examine tissue hypoxia by means of a model. From many oxygen modes of a contracting muscle, we have chosen the mode of maximum oxygen consumption with possible tissue hypoxia. The present study is intended to analyze the influence of local conditions—the apparent Km, muscle blood flow and intercapillary distance on oxygen mode of a hard-working muscle. The aim of the investigation was to find the effect of Km on the parameters of hypoxia zone in the muscle fiber, to consider the notion of maximum oxygen consumption of a muscle (VO2max), and to investigate quantitatively the values of VO2max as a function of muscle blood flow and intercapillary distance.
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Lyabakh, K.G. (1999). Mathematical Modeling of Oxygen Transport to Skeletal Muscle During Exercise. In: Eke, A., Delpy, D.T. (eds) Oxygen Transport to Tissue XXI. Advances in Experimental Medicine and Biology, vol 471. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4717-4_68
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DOI: https://doi.org/10.1007/978-1-4615-4717-4_68
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