Abstract
Real-time evaluation of brain vitality in situ could be done by monitoring different parameters, which are complementary to each other. During the last 40 years the following four minimally invasive techniques were developed and applied to monitor the brain in situ:
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(1)
Cerebral Blood Flow (CBF) using laser Doppler flowmetry (Stern et al., 1977; Dirnagl et al., 1989).
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(2)
Hemoglobin oxygenation or saturation (HbO2) by dual wavelength reflectometry (Rampil et al., 1992) or spectral analysis (Frank et al., 1989).
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(3)
Brain average oxygenation using oxygen electrodes (Mayevsky et al., 1980).
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(4)
Mitochondrial redox state by monitoring of NADH fluorescence using surface fluorometry (Chance et al., 1962; Jobsis et al., 1971b; Mayevsky and Chance, 1982).
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References
Chance B, Cohen P, Jobsis F, and Schoener B (1962) Intracellular oxidation-reduction states in vivo. Science 137:499–508.
Chance B and Legallias V (1959) Differential microfluorometer for the localization of reduced pyridine nucleotide in living cells. The Review of Scientific Instruments 30:732–735.
Chance B, Legallias V, and Schoener B (1962) Metabolically linked changes in fluorescence emission spectra of cortex of rat brain, kidney and adrenal gland. Nature 195:1073–1075.
Chance B and Thorell B (1959) Localization and kinetics of reduced pyridine nucleotide in living cells by micro-fluorometry. J. Biol. Chem. 234:3044–3050.
Chance B and Williams GR (1955) Respiratory enzymes in oxydative phosphorylation. I. Kinetics of oxygen utilization. J. Biol. Chem. 217:383–393.
Dirnagl U, Kaplan B, Jacewicz M, and Pulsinelli W (1989) Continuous measurement of cerebral cortical blood flow by Laser Doppler Flowmetry with a rat stroke model. J. CBF and Metab. 9:589–596.
Frank KH, Kessler M, Appelbaum K, and Dummler W (1989) The Erlangen micro-lightguide spectropho-tometer EMPHO I. Phys. Med. Biol. 34:1883–1900.
Haberl RL, Heizer ML, Marmarou A, and Ellis EF (1989) Laser doppler assessment of brain microcirculation: Effect of systemic alterations. Am. J. Physiol. 256:H1247–H1251.
Jobsis FF, O’Conner MJ, Rosenthal M, and VanBuren JM (1971a) Fluorometric monitoring of metabolic activity in the intact cerebral cortex. In: Anonymous Neurophysiology studied in man. Excerpta Medica, Amsterdam, pp 18–26.
Jobsis FF, O’Connor M, Vitale A, and Vreman H (1971b) Intracellular redox changes in functioning cerebral cortex. I. Metabolic effects of epileptiform activity. Neurophysiology 34:735–749.
Mayevsky A (1983a) Metabolic, ionic and electrical responses to experimental epilepsy in the awake rat. In: Baldy M, Moulinier DH, Ingvar DH, Meldrum BS (eds.) Proceedings First International Congress of Cerebral Blood Flow, Metabolism & Epilepsy. John Libbey, pp. 263-270.
Mayevsky A (1983b) Multiparameter monitoring of the awake brain under hyperbaric oxygenation. J. Appl. Physiol. 54:740–748.
Mayevsky A (1984a) Brain NADH redox state monitored in vivo by fiber optic surface fluorometry. Brain Res. Rev. 7:49–68.
Mayevsky A (1984b) Brain oxygen toxicity. Invited Review. In: Bachrach AJ, Matzen MM (eds.) Underwater Physiology. 8th Symposium Undersea Medical Society, Bethesda, Maryland, pp. 69-89.
Mayevsky A (1992) Cerebral blood flow and brain mitochondrial redox state responses to various perturbations in gerbils. In: Erdmann W (ed.) Oxygen Transport to Tissue XIV. Plenum Press, pp. 707-716.
Mayevsky A and Chance B (1973) A new long-term method for the measurement of NADH fluorescence in intact rat brain with implanted cannula. Adv. Exp. Med. Biol. 37A:239–244. New York Plenum Press.
Mayevsky A and Chance B (1982) Intracellular oxidation reduction state measured in situ by a multichannel fiber-optic-surface fluorometer. Science 217:537–540.
Mayevsky A, Doron A, Manor T, Meilin S, Zarchin N, and Ouaknine GE (1996) Cortical spreading depression recorded from the human brain using a multiparametric monitoring system. Brain Res. 740:268–274.
Mayevsky A, Flamm ES, Pennie W, and Chance B (1991) A fiber optic based multiprobe system for intraoperative monitoring of brain functions. SPIE Proc. 1431:303–313.
Mayevsky A, Frank K, Muck M, Nioka S, Kessler M, and Chance B (1992) Multiparametric evaluation of brain functions in the Mongolian gerbil in vivo. J. Basic Clin. Physiol. Pharmacol. 3:323–342.
Mayevsky A, Lebourdais S, and Chance B (1980) The interrelation between brain PO2 and NADH oxidation-reduction state in the gerbil. J. Neurosci. Res. 5:173–182.
Mayevsky A, Meilin A, Rogatsky GG, Zarchin N, and Thorn SR (1995) Multiparametric monitoring of the awake brain exposed to carbon monoxide. J. Appl. Physiol. 78:1188–1196.
Mayevsky A, Meilin S, Manor T, Ornstein E, Zarchin N, and Sonn J (1998) Multiparametric monitoring of brain oxygen balance under experimental and clinical conditions. Neurol. Res. 20:S76–S80.
Mayevsky A and Weiss HR (1991) Cerebral blood flow and oxygen consumption in cortical spreading depression. J. CBF and Metab. 11:829–836.
Miller WC, Suich DM, and Unger KM (1987) Hyperbaric environment for chronic hypoxemia. J. Hyperbaric Med. 2:211–214.
Rampil IJ, Litt L, and Mayevsky A (1992) Correlated, simultaneous, multiple-wavelength optical monitoring in vivo of localized cerebrocortical NADH and brain microvessel hemoglobin oxygen saturation. J. Clin. Monit. 8:216–225.
Stern MD, Lappe DL, Bowen PD, Chimosky JE, Holoway GA, and Keiser HR (1977) Continuous measurement of tissue blood flow by Laser Doppler spectroscopy. Am. J. Physiol. 232:H441–H448.
Torbati D, Parolla D, and Lavy S (1979) Organ blood flow, cardiac output, arterial blood pressure, and vascular resistance in rats exposed to various oxygen pressures. Aviat. Space Environ. Med. 50:256–263.
Wadhwani KC and Rapoport SI (1990) Blood flow in the central and peripheral nervous systems. In: Shephard AP, Oberg PA (eds.) Laser-Doppler Blood Flowmetry. Kluwer Academic Pub., Boston, pp. 265–304.
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Mayevsky, A., Meilin, S., Manor, T., Zarchin, N., Sonn, J. (1999). Optical Monitoring of Nadh Redox State and Blood Flow as Indicators of Brain Energy Balance. In: Eke, A., Delpy, D.T. (eds) Oxygen Transport to Tissue XXI. Advances in Experimental Medicine and Biology, vol 471. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4717-4_16
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DOI: https://doi.org/10.1007/978-1-4615-4717-4_16
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