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Regulation of Cerebral Oxygen Delivery

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Oxygen Transport to Tissue XXI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 471))

Abstract

Under normal conditions, it is generally accepted that for the adult mammalian cortex, almost all the energy required for cerebral ATP generation is supplied by oxidation of glucose through the tri-carboxylic acid cycle (Siesjö, 1978), and cerebral metabolic rates of oxygen and glucose use (i.e., CMRO2 and CMRglc, respectively) are regionally modified to fulfil metabolic needs through regulation of cerebral blood flow (CBF) and volume (CBV) (Roy and Sherrington, 1890). However, some positron emission tomography (PET) results have reported that during brain activation of awake humans CBF increases by a greater fraction than CMRO2 (Fox and Raichle, 1986; Fox et al., 1988). In the last few decades, ever since in vivo cortical measurements could be made of CBF and/or CMRO2, the mechanisms for the proportionality of changes between CBF and CMRO2 due to physiological perturbations have remained intangible, and the measured stoichiometries have varied reflecting a variety of experimental methods and/or conditions. However, regionally tight relationship between CMRO2 and CBF has been observed at rest with a ratio of about ~1:1 (Kety et al., 1947–8; Raichle et al., 1976).

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Author information

Authors and Affiliations

  1. Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA

    Fahmeed Hyder & Douglas L. Rothman

  2. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA

    Robert G. Shulman

Authors
  1. Fahmeed Hyder
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  2. Robert G. Shulman
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  3. Douglas L. Rothman
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Editor information

Editors and Affiliations

  1. Semmelweis University of Medicine, Budapest, Hungary

    Andras Eke

  2. University College London, London, England

    David T. Delpy

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© 1999 Springer Science+Business Media New York

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Hyder, F., Shulman, R.G., Rothman, D.L. (1999). Regulation of Cerebral Oxygen Delivery. In: Eke, A., Delpy, D.T. (eds) Oxygen Transport to Tissue XXI. Advances in Experimental Medicine and Biology, vol 471. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4717-4_12

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  • DOI: https://doi.org/10.1007/978-1-4615-4717-4_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7137-3

  • Online ISBN: 978-1-4615-4717-4

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