Abstract
Synovial fluids (SF) from patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), gout, and osteoarthritis (OA) were investigated for the levels of interleukin (IL)-1β, IL-6 and IL-8, tryptophan (Trp) and indoleamine 2,3-dioxygenase (IDO) activity. Significant differences exist in the levels of IL-1β between inflammatory arthritides RA, PsA and gout and non inflammatory arthritis, such as OA. The highest concentration of IL-1β was found in RA, that showed high levels also of IL-6 and IL-8. In the same disease we also found the highest IDO activity and the lowest Trp concentration. In addition, IDO activity seems to be related with the decrease in Trp, as demonstrated by the inverse correlation found between these two substances in the SF of all patients.
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References
Bertazzolo N., Punzi L., Stefani M.P., Cesaro G., Pianon M., Finco B., and Todesco S., 1994, Interrelationships between interleukin, (IL)-1, IL-6 and IL-8 in synovial fluid of various arthropathies Agents Actions 41:90–92.
Brown R.R., Ozaki Y., Datta S.P, Borden E.C., Sondel P.M., and Malone D.G., 1991, Implications of interferon-induced tryptophan catabolism in cancer, autoimmune diseases and AIDS, in: Kynurenine and Serotonin Pathways, R. Schwarcz et al., eds, Plenum Press, New York, pp. 425–435.
Christen S., Peterhans E., and Stocker R., 1990, Antioxidant activities of some tryptophan metabolites: Possible implication for inflammatory diseases, Proc. Natl. Acad. Sci. USA, 87:2506–2510.
Costa C., Bettero A., and Allegri G., 1984, Rapid determination of tryptophan and its metabolites along the kynurenine pathway by HPLC, in: Progress in Tryptophan and Serotonin Research, W. De Gruyter & Co ed., Berlin, pp. 67–70.
Dayer J.M. and Demczuk S., 1984, Cytokines and other mediators in rheumatoid arthritis, Springer Semin Immunopathol., 7:387–413.
Hayaishi O., Hirata F., Ohmishi T., Henry J.-P., Rosenthal I., and Katoh A., 1977, Indoleamine 2,3-dioxygenase. Incorporation of 18O2-and 18O2 into the reaction products, J. Biol. Chem., 252:3548–3550.
Hopkins S.J., Humphreys M., and Jayson M.I.V., 1988, Cytokines in synovial fluid. I. The presence of biologically active and immunoreactive IL-1, Clin. Exp. Immunol, 72:422–427.
Houssian F.A., de Vogelaer J.P., van Damme J., de Deuxchaisnes C.N., and van Snick J., 1988, Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides, Arthritis Rheum., 31:784–787.
Malone D.G., Dolan P.W., Brown R.R., Kalayoglu M.V., Arend R.A., Byrne G.I., and Ozaki Y., 1994, Interferon-gamma induced production of indoleamine 2,3-dioxygenase in cultured human synovial cells, J. Rheumatol, 21:1011–1019.
Peichl P., Ceska M., Effenberger F., Haberhauer F., Broell H., and Lindley I., 1991, Presence of NAP-1/IL-8 in synovial fluids indicates a possible pathogenic role in rheumatoid arthritis, Scand. J. Immunol., 34:333–339.
Pianon M., Punzi L., Allegri G., Costa C., Bertazzolo N., Rizzi E., Rossini P., and Todesco S., 1995, Le tryptophane dans le liquide synovial et ses rapports avec les interleukines (IL) pro-inflammatoires. Rev Rheum., 62:732.
Punzi L., Pianon M., Bertazzolo N., Finco B., Cesaro G., and Todesco S., 1994, Interrelationship between synovial fluid interleukin (IL)-6, IL-1β and disease activity indices in rheumatoid arthritis. Rheumatol Int., 14:83–84.
Punzi L., Bertazzolo N., Pianon M., Rizzi E., Rossini P., and Todesco S., 1996, Synovial fluid levels of proin-flammatory interleukins and their inter-relationships in elderly vs younger onset rheumatoid arthritis, Aging Clin. Exp. Res., 8:277–281.
Remick D.G., DeForge L.E., Sullivan J.F., and Showell H.J., 1992, Profile of cytokines in synovial fluid specimens from patients with arthritis. Interleukin 8 (IL-8) and IL-6 correlate with inflammatory arthritides, Immun. Invest., 21:321–327.
Shimizu T., Nomiyama S., Hirata F., and Hayaishi O., 1978, Indoleamine 2,3-dioxygenase. Purification and some properties, J. Biol. Chem. 253:4700–4706.
Takikawa O., Yoshida R., Kido R., and Hayaishi O., 1986, Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase, J. Biol. Chem., 261:3648–3653.
Yoshida R. and Hayaishi O., 1978, Induction of pulmonary indoleamine 2,3-dioxygenase by intraperitoneal injection of bacterial lipopolysaccharide, Proc. Natl. Acad. Sci. USA, 75:3998–4000.
Yoshida R., Urade Y., Tokuda M., and Hayaishi O., 1979, Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection, Proc. Natl. Acad. Sci. USA, 76:4084–4086.
Yoshida R., Imanishi J., Oku T., Kishida T., and Hayaishi O., 1981, Induction of pulmonary indoleamine 2,3-dioxygenase by interferon, Proc. Natl. Acad. Sci. USA, 78:129–132.
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Bertazzo, A. et al. (1999). Tryptophan Catabolism in Synovial Fluid of Various Arthropathies and its Relationship with Inflammatory Cytokines. In: Huether, G., Kochen, W., Simat, T.J., Steinhart, H. (eds) Tryptophan, Serotonin, and Melatonin. Advances in Experimental Medicine and Biology, vol 467. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4709-9_70
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DOI: https://doi.org/10.1007/978-1-4615-4709-9_70
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