Abstract
The role of IFN-γ in the expression of indoleamine 2,3-dioxygenase (IDO), a tryptophan oxidizing enzyme, in mouse tissues under physiological and pathological conditions was investigated using IFN-γ-knockout mice. The results revealed that i) the expression of IDO in the large intestine or in the cecum is mediated by IFN-γ, ii) for the systemic IDO induction under endotoxin shock, IFN-γ is a dominant inducer but not essential, and an IFN-γ-independent mechanism is also operative, iii) the systemic induction of IDO caused by IL-12 or Pokeweed mitogen is mediated by IFN-γ, and iv) the constitutive IDO expression in the epididymis is IFN-γ-independent.
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Takikawa, O., Tagawa, Yi., Iwakura, Y., Yoshida, R., Truscott, R.J.W. (1999). Interferon-Gamma-Dependent/Independent Expression of Indoleamine 2,3-Dioxygenase. In: Huether, G., Kochen, W., Simat, T.J., Steinhart, H. (eds) Tryptophan, Serotonin, and Melatonin. Advances in Experimental Medicine and Biology, vol 467. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4709-9_68
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DOI: https://doi.org/10.1007/978-1-4615-4709-9_68
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