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Possible Role of Microglial Prostanoids and Free Radicals in Neuroprotection and Neurodegeneration

  • Chapter
The Functional Roles of Glial Cells in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 468))

Abstract

Microglial cells are important effector cells in brain inflammation and immune response. In normal brain, microglial cells show a down-regulated immunophenotype, adapted to the specialised microenvironment of the central nervous system, but they rapidly respond to a number of different insults and become activated. Microglial activation is a natural and defensive process, addressed mainly to host defence and neuroprotection. However, in some circumstances, microglial activation can be inappropriately triggered or deployed to excess, and eventually contribute to the damage or death of the surrounding cells (Kreutzberg, 1996).

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Authors and Affiliations

  1. Neurobiology Section Laboratory of Pathophysiology Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy

    Luisa Minghetti, Elisabetta Polazzi, Alessia Nicolini, Anita Greco & Giulio Levi

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  1. Luisa Minghetti
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  2. Elisabetta Polazzi
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  3. Alessia Nicolini
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  4. Anita Greco
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  5. Giulio Levi
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Editors and Affiliations

  1. University of Geneva Medical School, Geneva, Switzerland

    Marco Tsacopoulos

  2. Hellenic Pasteur Institute, Athens, Greece

    Rebecca Matsas

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Minghetti, L., Polazzi, E., Nicolini, A., Greco, A., Levi, G. (1999). Possible Role of Microglial Prostanoids and Free Radicals in Neuroprotection and Neurodegeneration. In: Matsas, R., Tsacopoulos, M. (eds) The Functional Roles of Glial Cells in Health and Disease. Advances in Experimental Medicine and Biology, vol 468. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4685-6_9

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  • DOI: https://doi.org/10.1007/978-1-4615-4685-6_9

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