Abstract
Perchlorate (ClO4 −) is an anion commercially available as a salt with many cations. The most common forms of perchlorate include ammonium perchlorate (used as a solid rocket oxidant and ignitable source in munitions and fireworks) and potassium perchlorate (used in road flares and in air bag inflation systems as well as to treat Graves’ Disease [hypothyroidism] since the 1950s). Other forms of perchlorate include ammonium perchlorate, potassium perchlorate, sodium perchlorate, aluminum perchlorate, hydrazinium perchlorate, hydrogen perchlorate, hydroxylammonium perchlorate, lithium perchlorate, magnesium perchlorate, nitronium perchlorate, and perchloric acid. Perchlorate is also formed in laboratory waste as a byproduct of perchloric acid.
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References
Gray, H. Gray’s Anatomy. Running: Philadelphia, PA, 1974, passim.
Capen, C.C.; Martin, S.L. “The Effects of xenobiotics on the structure and function of thyroid follicular and c-cells.” Toxicologic Pathology 1989,17, 266–293.
Lehninger, A.L.; Nelson, D.L.; Cox, M.M. Principles of Biochemistry. New York: Worth, 1993; p. 752.
Hammarstrom S., K. Sterling, K.; Milch, P.O. “Thyroid hormone action: the mitochon-drial pathway.” Science 1977, 197, 966–999.
Wolff, J. “Perchlorate and the thyroid gland.” Pharmacological Reviews 1998, 50, 89–105.
Eichler, O.; Hackenthal, E. “Über ausscheidung und Stoffwechsel von perchlorate gemessen mit 36ClO4 −” Naunyn-Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie 1962, 243, 554–565.
Anbar, M.; Guttmann, S.; Lewitus, Z. “The mode of action of perchlorate ions on the iodine uptake of the thyroid gland.” Internationaljournal of Applied Radiation Isotopes 1959, 7, 87–96.
Wyngaarden, J.B.; Wright, B.M.; Ways, P. “The effects of certain anions upon the accumulation and retention of iodide by the thyroid gland.” Endocrinology 1952, 50, 537–549.
Wyngaarden, J.B.; Stanbury, J.B.; Rapp, B. “The effects of iodide, perchlorate, thiocya nate, and nitrate administration upon the iodide concentrating mechanism of the thyroid.” Endocrinology 1953, 52, 568–574.
Ingbar, S.H.; Freinkel, N. “Concentration gradients for radioiodide in unblocked thyroid glands of rats: effects of perchlorate.” Endocrinology 1956, 58, 95–103.
Wolff, J.; Maurey, J.R. “Thyroidal iodide transport: comparison of iodide with anions of periodic group VIIA.” Biochimica et Biophysica Acta 1962, 57, 422–426.
Wolff, J.; Maurey, J.R. “Thyroidal iodide transport: the role of ion size.” Biochimica et Biophysica Acta 1963, 69, 58–67.
Rocmans, P.A.; Penel, J.C.; Cantrain, F.R.; Dumont, J.E. “Kinetic analysis of iodide transport in dog thyroid slices: perchlorate-induced discharges.” American Journal of Physiology 1977, 232, E343–E352.
Krüskemper, H.L.; Kleinsorg, H. “Antithyroideal wirkung von perchlorate.” Naunyn-Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie 1954, 223, 460–480.
Eichler, O. “On the pharmacology of perchlorate” (in German). Naunyn-Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie 1929,144, 251–260.
Durand, M.J. “Reserches sur l’elimination des perchlorates, sur leur repartition dans les organs et sur leur toxicite.” Bulletin de la Societe de Chimique Biologique 1938, 20, 428–435.
Andreoli, T.E.; Carpenter, C.C.I.; Bennett, J.C.; Plum, F., Eds. Cecil Essentials of Medicine. Saunders: New York, 1997, passim.
National Research Council. Recommended Daily Allowances, 10th ed. National Academy Press: Washington, D.C., 1989.
Hetzel, B.S.; Maberly, G.F. “Iodine.”In W. Mertz,Ed., Trace Elements in Human and Animal Nutrition, 5th ed. Academic, New York, 1986, passim.
Matovinovic, J. “Endemic goiter and cretinism at the dawn of the third millennium.” Annual Review of Nutrition 1983, 3, 341–412.
National Research Council. Iodine Nutriture in the United States. Summary of a Conference, October 31, 1970. Report of the Committee on Food Protection, Food and Nutrition Board, National Academy of Sciences: Washington D.C., 1970.
Lamm, S.H.; Doemland, M. “Has perchlorate in drinking water increased the rate of congenital hypothyroidism?” Journal of Occupational and Environmental Medicine 1999, 41, 409–411.
Holt, D.W.; Tucker, G.T.; Jackson, P.R. Storey, G.C.A. “Amiodarone pharmaco-kinetics.” American Heart Journal1983,106, 840–847.
Latini, R.; Tognoni, G.; Kates, R.E. “Clinical pharmacokinetics of amiodarone.” Clinical Pharmacokinetics 1984, 9,136–156.
Léger, F.A.; Fragu, P.; Rougier, P.; Laurent, M.F.; Vincens, M.; Auriol, M; Helal, O.B.; Chouette, G.; Savoie, J.C. “Iodine-induced thyrotoxicosis: analysis of 85 consecutive cases.” European Journal of Clinical Investigation 1984,14, 449–455.
Burger, A., Dinichert, D.; Nicod, P.; Jenny, M.; Lemarchand-Béraud, T.; Vallotton, M.D. “Effect of amiodarone on serum T3, rT3, T4, and TSH.” Journal of Clinical Investigation 1976, 58, 255–259.
Franklyn, J. A.; Davis, J.R.; Gamage, M.D.; Little, W. A.; Ramsden, D.B.; Sheppard, M.C. “Amiodarone and thyroid hormone action.” Clinical Endocrinolology 1985, 22, 257–264.
Melmed, S.; Nademanee, K.; Reed, A.W.; Hendrickson, J.; Singh, B.N.; Hershman, J.M. “Hyperthyroxinemia woth bradycardia and normal TSH secretion following chronic amiodarone administration.” Journal of Clinical Endocrinology and Metabolism 1981, 83, 997–1001.
Nademanee, K.; Piwonka, R.W.; Singh, B.N.; Hershman, J.M. “Amiodarone and thyroid function.” Progress in Cardiovascular Diseases 1989, 31, 427–437.
Singh, B.N.; Nademanee, K. “Amiodarone and thyroid function: clinical implications during antiarrythmic therapy.” American Heart Journal 1983, 106, 857–869.
Capiello, F.; Boldorini, R.; Tosoni, A; Praneo, S.; Bernasconi, R.; Raggi, U. “Ultrastructural evidence of thyroid damage in amiodarone-induced thyrotoxicosis.” Journal of Endocrinology Investigation 1995,18, 862–868.
Brennan M.D.; Erickson, D.Z.; Carney, JA.; Bahn, R.S. “Nongoitrous amiodarone-associated thyrotoxicosis: evidence of follicular disruption in vitro and in vivo.” Thyroid 1995, 5, 177–183.
Belshaw, B.E.; Becker, D. V. “Necrosis of follicular cells and discharge of iodine induced by administering iodide to iodine-deficient dogs.” Journal of Clinical Endocrinology and Metabolism 1973, 36, 466–474.
Many, M.C.; Mestdagh, C.; Van Den Hove, M.F.; Denef, J.F. “In vitro study of acute toxic effects of high iodine doses in human thyroid follicles.” Endocrinology 1992,131, 621–630.
Reichert, L.J.; DeRooy, H. A.M. Treatment of amiodarone induced hypothyroidism with potassium perchlorate and methimazideideole during amiodarone treatment. British Medical Journal 1989, 298, 1547–1548.
Martino, E.; Mariotti, S.; Aghini-Lombardi, F. Mariotti, S.; Lenziardi, M.; Baschieri, L.; Braverman, L.E.; Pinchera, A. “Short term administration of potassium perchlorate restores euthyroidism in amiodarone iodine-induced hypothyroidism.” Journal of Endocrinology Investigation 1986, 63, 1233–1236.
Martino, E.; Aghini-Lombardi, F.; Mariotti, S. “Treatment of amiodarone associated thyrotoxicosis by simultaneous administration of potassium perchlorate and methimasideideole.” Journal of Endocrinology Investigation 1986, 9, 201–207.
Trip, M.D.; Duren, D.R.; Wiersinga, W.M. “Two cases of amiodarone-induced thyrotoxicosis successfully treated with a short course of antithyroid drugs while amiodarone was continued.” British Heart Journal 1994, 72, 266–268.
Martino, E.; Aghini-Lombardi, F.; Mariotti, S.; Bartalena, L.; Braverman, L.; Pinchera, A. “Amiodarone: a common source of iodine-induced thyrotoxicosis.” Hormone Research 1987, 26, 158–171.
De Visscher, M.,Ed. Comprehensive Endocinology: The Thyroid Gland. Raven: New York, 1980; passim.
Trotter, W.R. “The relative toxicity of antithyroid drugs.” Journal of New Drugs 1962, 2, 333–343.
Krevans, J.R.; Asper, S.P.; Reinhoff, W.F. “Fatal aplastic anemia following use of potassium perchlorate in thyrotoxicosis.” JAMA: Journal of the American Medical Association 1962,181, 162–164.
Gjemdal, N. “Fatal aplastic anemia following use of potassium perchlorate in thyrotoxicosis.” Acta Medica Scandinavica 1963, 174, 129–131.
Barzalai, D.A.; Sheinfeld, M. “Fatal complications following the use of potassium perchlorate in thyrotoxicosis.” Israel Journal of Medical Sciences 1966, 2, 453–456.
Bartalena, L.; Brogioni, S.; Grasso, L.; Bogazzi, F.; Burelli, A.A.; Martino, E. “Treatment of amiodrane-induced thyrotoxicosis, a difficult challenge: results of a prospective study.” Journal of Clinical Endocrinology and Metabolism 1996, 81, 2930–2933.
Connel, J.M.C. “Long-term use of perchlorate.” Postgraduate Medicine 1981, 57, 516–517.
Reichert, L.J.; DeRooy, H.A.M.. “Treatment of amiodarone induced hypothyroidism with potassium perchlorate and methimazideideole during amiodarone treatment.” British Medical Journal 1989, 298, 1547–1548.
Burgi, H.; Benguerel, M; Knopp, I.; Kohler, H.; Studer, H. “Influence of perchlorate on the secretion on non-thyroxine iodine by the normal human thyroid gland.” European Journal of Clinical Investigations 4, 65–69.
Brabant, G.; Bergmann, P.; Kirsch, C.M.; Kohrle, I.; Hesch, R.D.; Von Zur Muhlem, A. “Early adaptation of thyrotropin and thyroglobulin secretion to experimentally decreased iodine supply in ma”Metabolism 1992, 4, 1093–1096.
Lamm, S.H.; Braverman, L.E.; Li, F.X.; Richman, K.; Pino, S.; Howearth, G. “Thyroid health status of ammonium perchlorate workers: a cross-sectional occupational health study.” Journal of Occupational and Environmental Medicine 1999, 41, 248–260.
Deichmann, W.; Gerade, H., Eds. Toxicology of Drugs and Chemicals. Academic: New York, 1969; passim.
Nzengung, V.; Wang, C. “Influences on phytoremediation for perchlorate contaminated water.” Preprints of Extended Abstracts, Division of Environmental Chemistry. 218th ACS National Meeting. ACS: 1999, 39(2), New Orleans, LA, August 22-26, 1999, 95–98.
Bacchus, S.; Susarla, S.; Wolfe, L.; Harvey, G.; McCutcheon, S. “Predicting field performance of herbaceous species for phytoremediation of perchlorate.” Preprints of Extended Abstracts, Division of Environmental Chemistry. 218th ACS National Meeting. ACS: 1999, 39(2), New Orleans, LA, August 22-26, 1999, 98–100.
Susarla, S.; Wolfe, N.; McCutcheon, S. “Perchlorate uptake in lettuce seedlings.” Preprints of Extended Abstracts, Division of Environmental Chemistry. 218th ACS National Meeting. ACS: 1999, 39(2), New Orleans, LA, August 22-26, 1999, 66–68.
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Clark, J.J.J. (2000). Toxicology of Perchlorate. In: Urbansky, E.T. (eds) Perchlorate in the Environment. Environmental Science Research, vol 57. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4303-9_3
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DOI: https://doi.org/10.1007/978-1-4615-4303-9_3
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