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The Continuum model and G1-control of the mammalian cell cycle

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

The continuum model of the mammalian division cycle proposes that there are no Gl-phase specific controls or events. The G1 phase is simply the time when processes begun in the previous cell cycle are completed. In this review, the continuum model is applied the variability of the Gl-phase, the existence of Gl-less cells, the ubiquitous Gl-phase arrest phenomenon, the effect of over-expressed cyclins on Gl-phase length, the statistical variation of the cell cycle, the reports of Gl-phase syntheses, the proposed variation in retinoblastoma protein phosphorylation in Gl-phase, and the myriad findings put forward to support the Gl-control model of the mammalian division cycle. The continuum model is a valid description of the mammalian division cycle.

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109-0620, USA

    Stephen Cooper

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  1. Stephen Cooper
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Editor information

Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Armelle Jézéquel  & 

  2. Centre National de la Recherche Scientifique, Université Paul Sabatier, Toulouse, France

    Bernard Ducommun

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© 2000 Springer Science+Business Media New York

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Cooper, S. (2000). The Continuum model and G1-control of the mammalian cell cycle. In: Meijer, L., Jézéquel, A., Ducommun, B. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4253-7_3

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  • DOI: https://doi.org/10.1007/978-1-4615-4253-7_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6909-7

  • Online ISBN: 978-1-4615-4253-7

  • eBook Packages: Springer Book Archive

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