Abstract
The molecular events that contribute to the progression of colon cancer are beginning to unravel. An initiating and probably obligatory event is the oncogenic activation of β-catenin. This can come about by the loss of its negative regulator the adenomatous polyposis coli (APC) protein, or by mutations in the β-catenin gene that result in a more stable protein product. The interaction between APC and β-catenin, and additional proteins that affect assembly and signaling along this pathway, are discussed.
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Polakis, P., Hart, M., Rubinfeld, B. (1999). Defects in the Regulation of β-Catenin in Colorectal Cancer. In: Colon Cancer Prevention. Advances in Experimental Medicine and Biology, vol 470. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4149-3_3
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DOI: https://doi.org/10.1007/978-1-4615-4149-3_3
Publisher Name: Springer, Boston, MA
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